A multiphysics model of photo-sensitive hydrogels in response to light-thermo-pH-salt coupled stimuli for biomedical applications
This paper aims to unveil the fundamental response mechanism of photo-sensitive hydrogels subject to light-thermo-pH-salt coupled stimuli, for their potential biomedical uses such as cell scaffolds and extracellular matrices, where biological activity largely depends on internal electrochemical chan...
| Main Authors: | , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2022
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/155273 |
| _version_ | 1826130523571879936 |
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| author | Chen, Xiao Li, Hua Lam, King-Yeung |
| author2 | School of Mechanical and Aerospace Engineering |
| author_facet | School of Mechanical and Aerospace Engineering Chen, Xiao Li, Hua Lam, King-Yeung |
| author_sort | Chen, Xiao |
| collection | NTU |
| description | This paper aims to unveil the fundamental response mechanism of photo-sensitive hydrogels subject to light-thermo-pH-salt coupled stimuli, for their potential biomedical uses such as cell scaffolds and extracellular matrices, where biological activity largely depends on internal electrochemical changes. To mimic the microenvironment of biomolecules or cells, we focus on a spirobenzopyran-modified N-isopropylacrylamide hydrogel incorporating acrylic acid as a proton generator and develop a multiphysics model to characterize its behaviour within aqueous solution in response to light intensity, temperature, buffer pH, and salt concentration. The model allows for concurrent chemical reactions, ionic diffusion, electrostatic effects and large mechanical deformation, as well as interaction with the solution domain. Validation was performed by comparison with the published experimental results and showed good agreement. It is demonstrated by the simulation results that the photo-sensitive hydrogel exhibits a varied sensitivity to the external stimuli if incorporated with different molar ratios of acrylic acid. The electrical and pH response characteristics of the hydrogel, especially those in neutral solution, may inspire some potential biomedical applications, such as photo-controlled drug release and cell growth. |
| first_indexed | 2024-10-01T07:57:48Z |
| format | Journal Article |
| id | ntu-10356/155273 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:57:48Z |
| publishDate | 2022 |
| record_format | dspace |
| spelling | ntu-10356/1552732022-03-07T08:55:53Z A multiphysics model of photo-sensitive hydrogels in response to light-thermo-pH-salt coupled stimuli for biomedical applications Chen, Xiao Li, Hua Lam, King-Yeung School of Mechanical and Aerospace Engineering Engineering::Mechanical engineering Photo-Sensitive Hydrogel Multiphysics Model This paper aims to unveil the fundamental response mechanism of photo-sensitive hydrogels subject to light-thermo-pH-salt coupled stimuli, for their potential biomedical uses such as cell scaffolds and extracellular matrices, where biological activity largely depends on internal electrochemical changes. To mimic the microenvironment of biomolecules or cells, we focus on a spirobenzopyran-modified N-isopropylacrylamide hydrogel incorporating acrylic acid as a proton generator and develop a multiphysics model to characterize its behaviour within aqueous solution in response to light intensity, temperature, buffer pH, and salt concentration. The model allows for concurrent chemical reactions, ionic diffusion, electrostatic effects and large mechanical deformation, as well as interaction with the solution domain. Validation was performed by comparison with the published experimental results and showed good agreement. It is demonstrated by the simulation results that the photo-sensitive hydrogel exhibits a varied sensitivity to the external stimuli if incorporated with different molar ratios of acrylic acid. The electrical and pH response characteristics of the hydrogel, especially those in neutral solution, may inspire some potential biomedical applications, such as photo-controlled drug release and cell growth. Nanyang Technological University The authors sincerely acknowledge the financial support from Nanyang Technological University Research Scholarships. 2022-03-07T08:55:53Z 2022-03-07T08:55:53Z 2020 Journal Article Chen, X., Li, H. & Lam, K. (2020). A multiphysics model of photo-sensitive hydrogels in response to light-thermo-pH-salt coupled stimuli for biomedical applications. Bioelectrochemistry, 135, 107584-. https://dx.doi.org/10.1016/j.bioelechem.2020.107584 1567-5394 https://hdl.handle.net/10356/155273 10.1016/j.bioelechem.2020.107584 32574995 2-s2.0-85086637101 135 107584 en Bioelectrochemistry © 2020 Elsevier B.V. All rights reserved. |
| spellingShingle | Engineering::Mechanical engineering Photo-Sensitive Hydrogel Multiphysics Model Chen, Xiao Li, Hua Lam, King-Yeung A multiphysics model of photo-sensitive hydrogels in response to light-thermo-pH-salt coupled stimuli for biomedical applications |
| title | A multiphysics model of photo-sensitive hydrogels in response to light-thermo-pH-salt coupled stimuli for biomedical applications |
| title_full | A multiphysics model of photo-sensitive hydrogels in response to light-thermo-pH-salt coupled stimuli for biomedical applications |
| title_fullStr | A multiphysics model of photo-sensitive hydrogels in response to light-thermo-pH-salt coupled stimuli for biomedical applications |
| title_full_unstemmed | A multiphysics model of photo-sensitive hydrogels in response to light-thermo-pH-salt coupled stimuli for biomedical applications |
| title_short | A multiphysics model of photo-sensitive hydrogels in response to light-thermo-pH-salt coupled stimuli for biomedical applications |
| title_sort | multiphysics model of photo sensitive hydrogels in response to light thermo ph salt coupled stimuli for biomedical applications |
| topic | Engineering::Mechanical engineering Photo-Sensitive Hydrogel Multiphysics Model |
| url | https://hdl.handle.net/10356/155273 |
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