Intermolecular reductive heck reaction of unactivated aliphatic alkenes with organohalides

Intermolecular reductive heck reaction of unactivated aliphatic alkenes with organohalides

A general intermolecular reductive Heck reaction of organohalides with both terminal and internal unactivated aliphatic alkenes has been first realized in high yield with complete anti-Markovnikov selectivity. The challenging vinyl bromides, aryl chlorides, and polysubstituted internal alkenes were...

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Bibliographic Details
Main Authors: Zheng, Kewang, Xiao, Guanlin, Guo, Tao, Ding, Yalan, Wang, Chengdong, Loh, Teck-Peng, Wu, Xiaojin
Other Authors: School of Physical and Mathematical Sciences
Format: Journal Article
Language:English
Published: 2022
Subjects:
Science::Chemistry
Hydrocarbons
Inorganic compounds
Online Access:https://hdl.handle.net/10356/155334
Description
Summary:A general intermolecular reductive Heck reaction of organohalides with both terminal and internal unactivated aliphatic alkenes has been first realized in high yield with complete anti-Markovnikov selectivity. The challenging vinyl bromides, aryl chlorides, and polysubstituted internal alkenes were first applied. More than 100 remote carbofunctionalized alkyl carboxylic acid derivatives were rapidly synthesized from easily accessible starting materials. The synthesis of drug molecules has further demonstrated the wide synthetic utility of this scalable strategy. Preliminary mechanistic studies are consistent with the proposed catalytic cycle.

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