Interactions of comorbid neuropsychiatric subsyndromes with neurodegenerative and cerebrovascular pathologies on cognition
Comorbid neuropsychiatric symptoms are commonly found in individuals with dementia and is likely influenced by a combination of neurodegenerative and cerebrovascular pathophysiology. We evaluated the associations of a validated composite MRI-based quantitative measure of both neurodegeneration (hipp...
| Main Authors: | , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
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2022
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| Online Access: | https://hdl.handle.net/10356/155756 |
| _version_ | 1811695123612827648 |
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| author | Kan, Cheuk Ni Xu, Xin Schmetterer, Leopold Venketasubramanian, Narayanaswamy Chen, Christopher Tan, Chin Hong |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Kan, Cheuk Ni Xu, Xin Schmetterer, Leopold Venketasubramanian, Narayanaswamy Chen, Christopher Tan, Chin Hong |
| author_sort | Kan, Cheuk Ni |
| collection | NTU |
| description | Comorbid neuropsychiatric symptoms are commonly found in individuals with dementia and is likely influenced by a combination of neurodegenerative and cerebrovascular pathophysiology. We evaluated the associations of a validated composite MRI-based quantitative measure of both neurodegeneration (hippocampus volume and cortical thickness of AD-specific regions) and cerebrovascular disease (CeVD; white matter hyperintensities and infarcts) with neuropsychiatric subsyndromes, and their interactions on cognition in a community-based sample across the disease spectrum (N = 773). Lower composite MRI scores corresponding to greater comorbid neurodegeneration and CeVD burden were associated with hyperactivity (OR = 1.48) and apathy (OR = 1.90) subsyndromes. Lower MRI scores with concomitant hyperactivity was associated with greater cognitive impairment, especially in patients who were at least moderately impaired, while the interaction with apathy was not dependent on disease stage. These MRI scores interaction models resulted in a better fit than models consisting of neurodegeneration or CeVD alone. Integrating multiple biomarkers with specific, disease stage-dependent neuropsychiatric subsyndromes may provide a more holistic risk profile to facilitate the identification of individuals at the highest risk of disease progression. |
| first_indexed | 2024-10-01T07:18:28Z |
| format | Journal Article |
| id | ntu-10356/155756 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:18:28Z |
| publishDate | 2022 |
| record_format | dspace |
| spelling | ntu-10356/1557562023-03-05T15:34:11Z Interactions of comorbid neuropsychiatric subsyndromes with neurodegenerative and cerebrovascular pathologies on cognition Kan, Cheuk Ni Xu, Xin Schmetterer, Leopold Venketasubramanian, Narayanaswamy Chen, Christopher Tan, Chin Hong School of Chemical and Biomedical Engineering Lee Kong Chian School of Medicine (LKCMedicine) School of Social Sciences Singapore National Eye Center Duke-NUS Medical School SERI-NTU Advanced Ocular Engineering (STANCE) Science::Medicine Alzheimer’s Disease Cognition Comorbid neuropsychiatric symptoms are commonly found in individuals with dementia and is likely influenced by a combination of neurodegenerative and cerebrovascular pathophysiology. We evaluated the associations of a validated composite MRI-based quantitative measure of both neurodegeneration (hippocampus volume and cortical thickness of AD-specific regions) and cerebrovascular disease (CeVD; white matter hyperintensities and infarcts) with neuropsychiatric subsyndromes, and their interactions on cognition in a community-based sample across the disease spectrum (N = 773). Lower composite MRI scores corresponding to greater comorbid neurodegeneration and CeVD burden were associated with hyperactivity (OR = 1.48) and apathy (OR = 1.90) subsyndromes. Lower MRI scores with concomitant hyperactivity was associated with greater cognitive impairment, especially in patients who were at least moderately impaired, while the interaction with apathy was not dependent on disease stage. These MRI scores interaction models resulted in a better fit than models consisting of neurodegeneration or CeVD alone. Integrating multiple biomarkers with specific, disease stage-dependent neuropsychiatric subsyndromes may provide a more holistic risk profile to facilitate the identification of individuals at the highest risk of disease progression. Ministry of Education (MOE) Nanyang Technological University National Medical Research Council (NMRC) Submitted/Accepted version This study was supported by Nanyang Technological University, Singapore Start-Up Grant M40824100 and MOE AcRF Tier 1 M4012193. The Epidemiology of Dementia in Singapore (EDIS) study is supported by the National Medical Research Council (NMRC), Singapore (NMRC/CG/NUHS/2010 [Grant no.: R-184-006- 184-511]) and (NMRC/CSA/038/2013). 2022-03-18T06:23:34Z 2022-03-18T06:23:34Z 2022 Journal Article Kan, C. N., Xu, X., Schmetterer, L., Venketasubramanian, N., Chen, C. & Tan, C. H. (2022). Interactions of comorbid neuropsychiatric subsyndromes with neurodegenerative and cerebrovascular pathologies on cognition. Neurobiology of Aging, 109, 239-246. https://dx.doi.org/10.1016/j.neurobiolaging.2021.10.008 0197-4580 https://hdl.handle.net/10356/155756 10.1016/j.neurobiolaging.2021.10.008 34814099 2-s2.0-85119423731 109 239 246 en M40824100 NMRC/CG/NUHS/2010 M4012193. R-184-006-184-511 NMRC/CSA/038/2013 Neurobiology of Aging © 2021 Elsevier Inc. All rights reserved. This paper was published in Neurobiology of Aging and is made available with permission of Elsevier Inc. application/pdf |
| spellingShingle | Science::Medicine Alzheimer’s Disease Cognition Kan, Cheuk Ni Xu, Xin Schmetterer, Leopold Venketasubramanian, Narayanaswamy Chen, Christopher Tan, Chin Hong Interactions of comorbid neuropsychiatric subsyndromes with neurodegenerative and cerebrovascular pathologies on cognition |
| title | Interactions of comorbid neuropsychiatric subsyndromes with neurodegenerative and cerebrovascular pathologies on cognition |
| title_full | Interactions of comorbid neuropsychiatric subsyndromes with neurodegenerative and cerebrovascular pathologies on cognition |
| title_fullStr | Interactions of comorbid neuropsychiatric subsyndromes with neurodegenerative and cerebrovascular pathologies on cognition |
| title_full_unstemmed | Interactions of comorbid neuropsychiatric subsyndromes with neurodegenerative and cerebrovascular pathologies on cognition |
| title_short | Interactions of comorbid neuropsychiatric subsyndromes with neurodegenerative and cerebrovascular pathologies on cognition |
| title_sort | interactions of comorbid neuropsychiatric subsyndromes with neurodegenerative and cerebrovascular pathologies on cognition |
| topic | Science::Medicine Alzheimer’s Disease Cognition |
| url | https://hdl.handle.net/10356/155756 |
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