In situ nanozyme-amplified NIR-II phototheranostics for tumor-specific imaging and therapy
The discovery of near-infrared-II (NIR-II) tumor phototheranostics holds a great promise for use in nanomedicine on account of its enhanced penetration depth, high spatial resolution, and noninvasiveness. However, contemporary "always on" phototherapeutic agents often have many undesirable...
| Main Authors: | , , , , |
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| Format: | Journal Article |
| Language: | English |
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2022
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| Online Access: | https://hdl.handle.net/10356/155939 |
| _version_ | 1811696769899167744 |
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| author | Ma, Zhaoyu Mohamed F. Foda Liang, Huageng Zhao, Yanli Han, Heyou |
| author2 | School of Physical and Mathematical Sciences |
| author_facet | School of Physical and Mathematical Sciences Ma, Zhaoyu Mohamed F. Foda Liang, Huageng Zhao, Yanli Han, Heyou |
| author_sort | Ma, Zhaoyu |
| collection | NTU |
| description | The discovery of near-infrared-II (NIR-II) tumor phototheranostics holds a great promise for use in nanomedicine on account of its enhanced penetration depth, high spatial resolution, and noninvasiveness. However, contemporary "always on" phototherapeutic agents often have many undesirable side effects that hinder their clinical trial progress. To overcome this dilemma, an in situ nanozyme-amplified chromogenic nanoreactor by loading 3,3′,5,5′-tetramethylbenzidine (TMB) and ultrasmall PtAu nanoparticles into a metal-organic framework is developed for specific tumor theranostics, leaving normal tissues unharmed. As an intelligent photoacoustic diagnostic agent, the as-constructed nanoreactor remains silent until they enter the tumor site (H2O2-activated and acid-enhanced conditions) and turns on photoacoustic signal to render a preoperative tumor diagnosis. As a nanozyme, the special microenvironment of the tumor tissue is used to initiate its catalytic damage by reactive oxygen species for chemodynamic therapy (CDT). More importantly, the TMB is oxidized, and the subsequent photothermal therapy (PTT) can be realized, leading to an optimal combination of CDT and PTT to concurrently fight obstinate cancers. The present “all-in-one” phototheranostics utilize nanozyme-augmented NIR-II agents for specific tumor ablation, which are promising for further development of intelligent nanozymes in the tumor therapy. |
| first_indexed | 2024-10-01T07:44:38Z |
| format | Journal Article |
| id | ntu-10356/155939 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:44:38Z |
| publishDate | 2022 |
| record_format | dspace |
| spelling | ntu-10356/1559392023-02-28T19:26:55Z In situ nanozyme-amplified NIR-II phototheranostics for tumor-specific imaging and therapy Ma, Zhaoyu Mohamed F. Foda Liang, Huageng Zhao, Yanli Han, Heyou School of Physical and Mathematical Sciences Science::Chemistry Bioimaging Cancer Therapies The discovery of near-infrared-II (NIR-II) tumor phototheranostics holds a great promise for use in nanomedicine on account of its enhanced penetration depth, high spatial resolution, and noninvasiveness. However, contemporary "always on" phototherapeutic agents often have many undesirable side effects that hinder their clinical trial progress. To overcome this dilemma, an in situ nanozyme-amplified chromogenic nanoreactor by loading 3,3′,5,5′-tetramethylbenzidine (TMB) and ultrasmall PtAu nanoparticles into a metal-organic framework is developed for specific tumor theranostics, leaving normal tissues unharmed. As an intelligent photoacoustic diagnostic agent, the as-constructed nanoreactor remains silent until they enter the tumor site (H2O2-activated and acid-enhanced conditions) and turns on photoacoustic signal to render a preoperative tumor diagnosis. As a nanozyme, the special microenvironment of the tumor tissue is used to initiate its catalytic damage by reactive oxygen species for chemodynamic therapy (CDT). More importantly, the TMB is oxidized, and the subsequent photothermal therapy (PTT) can be realized, leading to an optimal combination of CDT and PTT to concurrently fight obstinate cancers. The present “all-in-one” phototheranostics utilize nanozyme-augmented NIR-II agents for specific tumor ablation, which are promising for further development of intelligent nanozymes in the tumor therapy. Agency for Science, Technology and Research (A*STAR) National Research Foundation (NRF) Submitted/Accepted version This work was supported by the National Key Research and Development Program of China (2018YFE0206900), the National Natural Science Foundation of China (21778020, 81927807, 31750110464, and 31950410755), the Sci-Tech Innovation Foundation of Huazhong Agricultural University (2662018PY024), the National Key R&D Program of China (2016YFD0500706), and Science and Technology Major Project of Guangxi (Gui Ke AA18118046). This work was also supported by the Singapore Agency for Science, Technology and Research (A*STAR) AME IRG grant (A20E5c0081) and the Singapore National Research Foundation Investigatorship (NRF-NRFI2018-03). 2022-03-25T02:12:31Z 2022-03-25T02:12:31Z 2021 Journal Article Ma, Z., Mohamed F. Foda, Liang, H., Zhao, Y. & Han, H. (2021). In situ nanozyme-amplified NIR-II phototheranostics for tumor-specific imaging and therapy. Advanced Functional Materials, 31(37), 2103765-. https://dx.doi.org/10.1002/adfm.202103765 1616-301X https://hdl.handle.net/10356/155939 10.1002/adfm.202103765 37 31 2103765 en A20E5c0081 NRF-NRFI2018-03 Advanced Functional Materials This is the peer reviewed version of the following article: Ma, Z., Mohamed F. Foda, Liang, H., Zhao, Y. & Han, H. (2021). In situ nanozyme-amplified NIR-II phototheranostics for tumor-specific imaging and therapy. Advanced Functional Materials, 31(37), 2103765, which has been published in final form at https://doi.org/10.1002/adfm.202103765. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. application/pdf |
| spellingShingle | Science::Chemistry Bioimaging Cancer Therapies Ma, Zhaoyu Mohamed F. Foda Liang, Huageng Zhao, Yanli Han, Heyou In situ nanozyme-amplified NIR-II phototheranostics for tumor-specific imaging and therapy |
| title | In situ nanozyme-amplified NIR-II phototheranostics for tumor-specific imaging and therapy |
| title_full | In situ nanozyme-amplified NIR-II phototheranostics for tumor-specific imaging and therapy |
| title_fullStr | In situ nanozyme-amplified NIR-II phototheranostics for tumor-specific imaging and therapy |
| title_full_unstemmed | In situ nanozyme-amplified NIR-II phototheranostics for tumor-specific imaging and therapy |
| title_short | In situ nanozyme-amplified NIR-II phototheranostics for tumor-specific imaging and therapy |
| title_sort | in situ nanozyme amplified nir ii phototheranostics for tumor specific imaging and therapy |
| topic | Science::Chemistry Bioimaging Cancer Therapies |
| url | https://hdl.handle.net/10356/155939 |
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