3D automated quantification of epidermal thickness and dermal heterogeneity in high-definition optical coherence tomography: Illustrative utility in morphea
Scleroderma is the most common form of fibrotic disease involving the skin, and the subtype that only affects the skin is known as morphea. The conventional investigation for cutaneous fibrotic diseases is skin biopsy, an invasive ex vivo procedure. Typically, another biopsy of adjacent normal skin...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2022
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/156206 |
| _version_ | 1826117750711386112 |
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| author | Lim, Gim Hui Yow, Ai Ping Zhao, Xiahong Wong, Damon Wing Kee Tey, Hong Liang |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Lim, Gim Hui Yow, Ai Ping Zhao, Xiahong Wong, Damon Wing Kee Tey, Hong Liang |
| author_sort | Lim, Gim Hui |
| collection | NTU |
| description | Scleroderma is the most common form of fibrotic disease involving the skin, and the subtype that only affects the skin is known as morphea. The conventional investigation for cutaneous fibrotic diseases is skin biopsy, an invasive ex vivo procedure. Typically, another biopsy of adjacent normal skin is required for comparison, in order to visualize the excessive dermal collagen deposition. Optical coherence tomography has been shown to be useful in fibrotic skin disorders, in obtaining in vivo cross-sectional visualization.1-3 The high-definition optical coherence tomography (HD-OCT) (Skintell®) developed more recently allows imaging with an enhanced resolution of 3µm in both axial and lateral planes and has an imaging depth of 570 µm. |
| first_indexed | 2024-10-01T04:32:28Z |
| format | Journal Article |
| id | ntu-10356/156206 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:32:28Z |
| publishDate | 2022 |
| record_format | dspace |
| spelling | ntu-10356/1562062022-04-11T02:52:11Z 3D automated quantification of epidermal thickness and dermal heterogeneity in high-definition optical coherence tomography: Illustrative utility in morphea Lim, Gim Hui Yow, Ai Ping Zhao, Xiahong Wong, Damon Wing Kee Tey, Hong Liang Lee Kong Chian School of Medicine (LKCMedicine) National Skin Centre Institute for Digital Molecular Analytics and Science (IDMxS) NTU Institute for Health Technologies Engineering::Chemical engineering Engineering::Electrical and electronic engineering::Optics, optoelectronics, photonics Optical Coherence Tomography Morphea Skin Scleroderma is the most common form of fibrotic disease involving the skin, and the subtype that only affects the skin is known as morphea. The conventional investigation for cutaneous fibrotic diseases is skin biopsy, an invasive ex vivo procedure. Typically, another biopsy of adjacent normal skin is required for comparison, in order to visualize the excessive dermal collagen deposition. Optical coherence tomography has been shown to be useful in fibrotic skin disorders, in obtaining in vivo cross-sectional visualization.1-3 The high-definition optical coherence tomography (HD-OCT) (Skintell®) developed more recently allows imaging with an enhanced resolution of 3µm in both axial and lateral planes and has an imaging depth of 570 µm. Ministry of Health (MOH) National Medical Research Council (NMRC) Ministry of Health’s National Medical Research Council, Singapore, under the Clinician Scientist Award—NMRC/CSA-INV/0023/2017. 2022-04-11T02:52:11Z 2022-04-11T02:52:11Z 2021 Journal Article Lim, G. H., Yow, A. P., Zhao, X., Wong, D. W. K. & Tey, H. L. (2021). 3D automated quantification of epidermal thickness and dermal heterogeneity in high-definition optical coherence tomography: Illustrative utility in morphea. Skin Research & Technology, 27(5), 977-979. https://dx.doi.org/10.1111/srt.13005 0909-752X https://hdl.handle.net/10356/156206 10.1111/srt.13005 33511640 2-s2.0-85099805814 5 27 977 979 en NMRC/CSA-INV/0023/2017 Skin Research & Technology © 2021 John Wiley & Sons A/S. All rights reserved. |
| spellingShingle | Engineering::Chemical engineering Engineering::Electrical and electronic engineering::Optics, optoelectronics, photonics Optical Coherence Tomography Morphea Skin Lim, Gim Hui Yow, Ai Ping Zhao, Xiahong Wong, Damon Wing Kee Tey, Hong Liang 3D automated quantification of epidermal thickness and dermal heterogeneity in high-definition optical coherence tomography: Illustrative utility in morphea |
| title | 3D automated quantification of epidermal thickness and dermal heterogeneity in high-definition optical coherence tomography: Illustrative utility in morphea |
| title_full | 3D automated quantification of epidermal thickness and dermal heterogeneity in high-definition optical coherence tomography: Illustrative utility in morphea |
| title_fullStr | 3D automated quantification of epidermal thickness and dermal heterogeneity in high-definition optical coherence tomography: Illustrative utility in morphea |
| title_full_unstemmed | 3D automated quantification of epidermal thickness and dermal heterogeneity in high-definition optical coherence tomography: Illustrative utility in morphea |
| title_short | 3D automated quantification of epidermal thickness and dermal heterogeneity in high-definition optical coherence tomography: Illustrative utility in morphea |
| title_sort | 3d automated quantification of epidermal thickness and dermal heterogeneity in high definition optical coherence tomography illustrative utility in morphea |
| topic | Engineering::Chemical engineering Engineering::Electrical and electronic engineering::Optics, optoelectronics, photonics Optical Coherence Tomography Morphea Skin |
| url | https://hdl.handle.net/10356/156206 |
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