PD-L1 alternative splicing

PD-L1 is an immune checkpoint molecule which is upregulated in some tumors to evade the immune response. Generation of truncated and nonfunctional PD-L1 variants by modulation of alternative splicing presents a novel strategy for cancer treatments. PD-L1 alternative splicing was studied using minige...

Full description

Bibliographic Details
Main Author: Zhen, Yashu
Other Authors: Francesc Xavier Roca Castella
Format: Thesis-Doctor of Philosophy
Language:English
Published: Nanyang Technological University 2022
Subjects:
Online Access:https://hdl.handle.net/10356/156429