Chelating phosphine-N-heterocyclic carbene platinum complexes via catalytic asymmetric hydrophosphination and their cytotoxicity toward MKN74 and MCF7 cancer cell lines

Chelating phosphine-N-heterocyclic carbene platinum complexes via catalytic asymmetric hydrophosphination and their cytotoxicity toward MKN74 and MCF7 cancer cell lines

A series of activated vinyl azoles was hydrophosphinated in the presence of a chiral palladacycle catalyst under mild conditions to give enantioenriched phosphine azoles with moderate enantioselectivities and yields. The racemic phosphine azoles were transformed into eleven novel chelating phosphine...

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Bibliographic Details
Main Authors: Seah, Jeffery Wee Kiong, Lee, Jeannie Xue Ting, Li, Yongxin, Pullarkat, Sumod A., Tan, Nguan Soon, Leung, Pak-Hing
Other Authors: School of Physical and Mathematical Sciences
Format: Journal Article
Language:English
Published: 2022
Subjects:
Science::Chemistry
Chelating Phosphines
Cells
Online Access:https://hdl.handle.net/10356/157005
Description
Summary:A series of activated vinyl azoles was hydrophosphinated in the presence of a chiral palladacycle catalyst under mild conditions to give enantioenriched phosphine azoles with moderate enantioselectivities and yields. The racemic phosphine azoles were transformed into eleven novel chelating phosphine-N-heterocyclic carbene (NHC) platinum complexes. The drug efficacies of nine selected phosphine-NHC platinum(II) chlorides in two cancer cell lines (MKN74 and MCF7) were evaluated, and two were found to exhibit activities comparable to that of cisplatin.

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