Fabrication of microstructured calcium phosphate ceramics scaffolds by material extrusion-based 3D printing approach
Natural materials such as bone and enamel have intricate microstructures with inorganic minerals oriented to perform multiple mechanical and biological functions. Current additive manufacturing methods for biominerals from the calcium phosphate (CaP) family enable fabrication of custom-shaped bioact...
| Main Authors: | , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2022
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/157094 |
| _version_ | 1811679295357059072 |
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| author | Le Ferrand, Hortense Dee, Peifang Tan, Sharlene |
| author2 | School of Mechanical and Aerospace Engineering |
| author_facet | School of Mechanical and Aerospace Engineering Le Ferrand, Hortense Dee, Peifang Tan, Sharlene |
| author_sort | Le Ferrand, Hortense |
| collection | NTU |
| description | Natural materials such as bone and enamel have intricate microstructures with inorganic minerals oriented to perform multiple mechanical and biological functions. Current additive manufacturing methods for biominerals from the calcium phosphate (CaP) family enable fabrication of custom-shaped bioactive scaffolds with controlled pore structures for patient-specific bone repair. Yet, these scaffolds do not feature intricate microstructures similar to those found in natural materials. In this work, we used direct material extrusion to 3D print water-based inks containing CaP microplatelets, and obtained microstructured scaffolds with various designs. To be shear-thinning and printable, the ink incorporated a concentration of 21 – 24 vol% CaP microplatelets of high aspect ratio. Good shape retention, print fidelity and overhanging layers were achieved by simultaneous printing and drying. Combined with the 3D design, versatile CaP microstructured objects can be built, from porous scaffolds to bulk parts. Extruded filaments featured a core-shell microstructure with graded microplatelet orientations, which was not affected by the printing parameters and the print design. A simple model is proposed to predict the core-shell microstructure according to the ink rheology. Given the remaining open porosity after calcination, microstructured scaffolds could be infiltrated with an organic phase in future to yield CaP biocomposites for hard tissue engineering. |
| first_indexed | 2024-10-01T03:06:53Z |
| format | Journal Article |
| id | ntu-10356/157094 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T03:06:53Z |
| publishDate | 2022 |
| record_format | dspace |
| spelling | ntu-10356/1570942022-05-07T20:11:32Z Fabrication of microstructured calcium phosphate ceramics scaffolds by material extrusion-based 3D printing approach Le Ferrand, Hortense Dee, Peifang Tan, Sharlene School of Mechanical and Aerospace Engineering School of Materials Science and Engineering Singapore Centre for 3D Printing Engineering::Manufacturing Engineering::Materials Robocasting Calcium Phosphate Natural materials such as bone and enamel have intricate microstructures with inorganic minerals oriented to perform multiple mechanical and biological functions. Current additive manufacturing methods for biominerals from the calcium phosphate (CaP) family enable fabrication of custom-shaped bioactive scaffolds with controlled pore structures for patient-specific bone repair. Yet, these scaffolds do not feature intricate microstructures similar to those found in natural materials. In this work, we used direct material extrusion to 3D print water-based inks containing CaP microplatelets, and obtained microstructured scaffolds with various designs. To be shear-thinning and printable, the ink incorporated a concentration of 21 – 24 vol% CaP microplatelets of high aspect ratio. Good shape retention, print fidelity and overhanging layers were achieved by simultaneous printing and drying. Combined with the 3D design, versatile CaP microstructured objects can be built, from porous scaffolds to bulk parts. Extruded filaments featured a core-shell microstructure with graded microplatelet orientations, which was not affected by the printing parameters and the print design. A simple model is proposed to predict the core-shell microstructure according to the ink rheology. Given the remaining open porosity after calcination, microstructured scaffolds could be infiltrated with an organic phase in future to yield CaP biocomposites for hard tissue engineering. National Research Foundation (NRF) Published version This work was supported by the National Research Foundation, Singapore, with the Fellowship NRFF12- 2020-0006. 2022-05-06T06:27:36Z 2022-05-06T06:27:36Z 2022 Journal Article Le Ferrand, H., Dee, P. & Tan, S. (2022). Fabrication of microstructured calcium phosphate ceramics scaffolds by material extrusion-based 3D printing approach. International Journal of Bioprinting, 8(2), 109-123. https://dx.doi.org/10.18063/ijb.v8i2.551 2424-8002 https://hdl.handle.net/10356/157094 10.18063/ijb.v8i2.551 2 8 109 123 en NRFF12- 2020-0002 International Journal of Bioprinting © 2022 Author(s). This is an Open-Access article distributed under the terms of the Creative Commons Attribution License, permitting distribution and reproduction in any medium, provided the original work is properly cited. application/pdf |
| spellingShingle | Engineering::Manufacturing Engineering::Materials Robocasting Calcium Phosphate Le Ferrand, Hortense Dee, Peifang Tan, Sharlene Fabrication of microstructured calcium phosphate ceramics scaffolds by material extrusion-based 3D printing approach |
| title | Fabrication of microstructured calcium phosphate ceramics scaffolds by material extrusion-based 3D printing approach |
| title_full | Fabrication of microstructured calcium phosphate ceramics scaffolds by material extrusion-based 3D printing approach |
| title_fullStr | Fabrication of microstructured calcium phosphate ceramics scaffolds by material extrusion-based 3D printing approach |
| title_full_unstemmed | Fabrication of microstructured calcium phosphate ceramics scaffolds by material extrusion-based 3D printing approach |
| title_short | Fabrication of microstructured calcium phosphate ceramics scaffolds by material extrusion-based 3D printing approach |
| title_sort | fabrication of microstructured calcium phosphate ceramics scaffolds by material extrusion based 3d printing approach |
| topic | Engineering::Manufacturing Engineering::Materials Robocasting Calcium Phosphate |
| url | https://hdl.handle.net/10356/157094 |
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