Development of novel self-healable hydrogel for wound healing applications
Bullfrog skins have a high potential as a novel source of gelatin as it has some advantages when compared to commercial sources of gelatin (porcine and bovine). In this study, we synthesized bullfrog derived gelatin and fabricated a hydrogel from bullfrog gelatin and oxidized dextran (ODEX). The dyn...
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| 其他作者: | |
| 格式: | Final Year Project (FYP) |
| 语言: | English |
| 出版: |
Nanyang Technological University
2022
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| 在线阅读: | https://hdl.handle.net/10356/157635 |
| _version_ | 1826128285327687680 |
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| author | Tjoang, Julia Stefanny |
| author2 | Dalton Tay Chor Yong |
| author_facet | Dalton Tay Chor Yong Tjoang, Julia Stefanny |
| author_sort | Tjoang, Julia Stefanny |
| collection | NTU |
| description | Bullfrog skins have a high potential as a novel source of gelatin as it has some advantages when compared to commercial sources of gelatin (porcine and bovine). In this study, we synthesized bullfrog derived gelatin and fabricated a hydrogel from bullfrog gelatin and oxidized dextran (ODEX). The dynamic covalent bond between the bullfrog gelatin and oxidized dextran allows the hydrogels to have self-healing property. It is hypothesized that this property, combined with the similarity of gelatin and the extracellular matrix (ECM), will make an excellent wound dressing material. The storage modulus of the hydrogel fabricated (800-1600 Pa) were comparable to other hydrogels used for wound healing application. However, we found that the fabricated hydrogels had degraded completely within 3 days and human immortalised skin cells were unable to form a monolayer when seeded on top of the hydrogels, indicating that the chemical stability and cytocompatibility of the hydrogels need to be further improved. |
| first_indexed | 2024-10-01T07:22:28Z |
| format | Final Year Project (FYP) |
| id | ntu-10356/157635 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:22:28Z |
| publishDate | 2022 |
| publisher | Nanyang Technological University |
| record_format | dspace |
| spelling | ntu-10356/1576352022-05-21T13:36:44Z Development of novel self-healable hydrogel for wound healing applications Tjoang, Julia Stefanny Dalton Tay Chor Yong School of Materials Science and Engineering cytay@ntu.edu.sg Engineering::Materials::Biomaterials Bullfrog skins have a high potential as a novel source of gelatin as it has some advantages when compared to commercial sources of gelatin (porcine and bovine). In this study, we synthesized bullfrog derived gelatin and fabricated a hydrogel from bullfrog gelatin and oxidized dextran (ODEX). The dynamic covalent bond between the bullfrog gelatin and oxidized dextran allows the hydrogels to have self-healing property. It is hypothesized that this property, combined with the similarity of gelatin and the extracellular matrix (ECM), will make an excellent wound dressing material. The storage modulus of the hydrogel fabricated (800-1600 Pa) were comparable to other hydrogels used for wound healing application. However, we found that the fabricated hydrogels had degraded completely within 3 days and human immortalised skin cells were unable to form a monolayer when seeded on top of the hydrogels, indicating that the chemical stability and cytocompatibility of the hydrogels need to be further improved. Bachelor of Engineering (Materials Engineering) 2022-05-21T13:36:44Z 2022-05-21T13:36:44Z 2022 Final Year Project (FYP) Tjoang, J. S. (2022). Development of novel self-healable hydrogel for wound healing applications. Final Year Project (FYP), Nanyang Technological University, Singapore. https://hdl.handle.net/10356/157635 https://hdl.handle.net/10356/157635 en application/pdf Nanyang Technological University |
| spellingShingle | Engineering::Materials::Biomaterials Tjoang, Julia Stefanny Development of novel self-healable hydrogel for wound healing applications |
| title | Development of novel self-healable hydrogel for wound healing applications |
| title_full | Development of novel self-healable hydrogel for wound healing applications |
| title_fullStr | Development of novel self-healable hydrogel for wound healing applications |
| title_full_unstemmed | Development of novel self-healable hydrogel for wound healing applications |
| title_short | Development of novel self-healable hydrogel for wound healing applications |
| title_sort | development of novel self healable hydrogel for wound healing applications |
| topic | Engineering::Materials::Biomaterials |
| url | https://hdl.handle.net/10356/157635 |
| work_keys_str_mv | AT tjoangjuliastefanny developmentofnovelselfhealablehydrogelforwoundhealingapplications |