Development of an on-chip skin substitute tester for non-invasive wearable sensor for physiological signals monitoring
Microneedles (MNs) are one of the upcoming research interests for miniaturized technology for diagnostic testing, drug delivery system and biomedical research. With these micro-sized biotechnologies emerge the need for the development of skin-on- chip devices. These devices are biomimetic systems th...
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| Format: | Final Year Project (FYP) |
| Language: | English |
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Nanyang Technological University
2022
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| Online Access: | https://hdl.handle.net/10356/158074 |
| _version_ | 1811687287263592448 |
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| author | Montoya, Maria Reina Katrina Martin |
| author2 | Poenar Daniel Puiu |
| author_facet | Poenar Daniel Puiu Montoya, Maria Reina Katrina Martin |
| author_sort | Montoya, Maria Reina Katrina Martin |
| collection | NTU |
| description | Microneedles (MNs) are one of the upcoming research interests for miniaturized technology for diagnostic testing, drug delivery system and biomedical research. With these micro-sized biotechnologies emerge the need for the development of skin-on- chip devices. These devices are biomimetic systems that are fabricated on microfluidic chips. Such systems replicate the tissue interface, mechanical properties, and functions of the skin.
This report discusses the development of a polydimethylsiloxane (PDMS) skin-on- chip designed to conduct in-vitro testing for a non-invasive microneedle-based wearable sensor for continuous physiological signals monitoring. The fabricated skin- on-chip tester showed promising results for the measurement of glucose concentration at lower concentration values. Further development in modelling the skin barrier will allow for better replication of the skin for the skin-on-chip tester, hence allowing for more accurate testing of the viability of the MN sensor. |
| first_indexed | 2024-10-01T05:13:55Z |
| format | Final Year Project (FYP) |
| id | ntu-10356/158074 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T05:13:55Z |
| publishDate | 2022 |
| publisher | Nanyang Technological University |
| record_format | dspace |
| spelling | ntu-10356/1580742023-07-07T19:26:09Z Development of an on-chip skin substitute tester for non-invasive wearable sensor for physiological signals monitoring Montoya, Maria Reina Katrina Martin Poenar Daniel Puiu School of Electrical and Electronic Engineering Continental - NTU Corporate Lab EPDPuiu@ntu.edu.sg Engineering::Electrical and electronic engineering Microneedles (MNs) are one of the upcoming research interests for miniaturized technology for diagnostic testing, drug delivery system and biomedical research. With these micro-sized biotechnologies emerge the need for the development of skin-on- chip devices. These devices are biomimetic systems that are fabricated on microfluidic chips. Such systems replicate the tissue interface, mechanical properties, and functions of the skin. This report discusses the development of a polydimethylsiloxane (PDMS) skin-on- chip designed to conduct in-vitro testing for a non-invasive microneedle-based wearable sensor for continuous physiological signals monitoring. The fabricated skin- on-chip tester showed promising results for the measurement of glucose concentration at lower concentration values. Further development in modelling the skin barrier will allow for better replication of the skin for the skin-on-chip tester, hence allowing for more accurate testing of the viability of the MN sensor. Bachelor of Engineering (Electrical and Electronic Engineering) 2022-05-29T06:49:24Z 2022-05-29T06:49:24Z 2022 Final Year Project (FYP) Montoya, M. R. K. M. (2022). Development of an on-chip skin substitute tester for non-invasive wearable sensor for physiological signals monitoring. Final Year Project (FYP), Nanyang Technological University, Singapore. https://hdl.handle.net/10356/158074 https://hdl.handle.net/10356/158074 en B2180-211 application/pdf Nanyang Technological University |
| spellingShingle | Engineering::Electrical and electronic engineering Montoya, Maria Reina Katrina Martin Development of an on-chip skin substitute tester for non-invasive wearable sensor for physiological signals monitoring |
| title | Development of an on-chip skin substitute tester for non-invasive wearable sensor for physiological signals monitoring |
| title_full | Development of an on-chip skin substitute tester for non-invasive wearable sensor for physiological signals monitoring |
| title_fullStr | Development of an on-chip skin substitute tester for non-invasive wearable sensor for physiological signals monitoring |
| title_full_unstemmed | Development of an on-chip skin substitute tester for non-invasive wearable sensor for physiological signals monitoring |
| title_short | Development of an on-chip skin substitute tester for non-invasive wearable sensor for physiological signals monitoring |
| title_sort | development of an on chip skin substitute tester for non invasive wearable sensor for physiological signals monitoring |
| topic | Engineering::Electrical and electronic engineering |
| url | https://hdl.handle.net/10356/158074 |
| work_keys_str_mv | AT montoyamariareinakatrinamartin developmentofanonchipskinsubstitutetesterfornoninvasivewearablesensorforphysiologicalsignalsmonitoring |