G4-PROTAC: targeted degradation of a G-quadruplex binding protein
G-quadruplex (G4)-binding proteins regulate important biological processes, but their interaction networks are poorly understood. We report the first use of G4 as warhead of a proteolysis-targeting chimera (G4-PROTAC) for targeted degradation of a G4-binding protein (RHAU/DHX36). G4-PROTAC provides...
| Main Authors: | , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2022
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/158329 |
| _version_ | 1824456966139805696 |
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| author | Patil, Kiran M. Chin, Danielle Seah, Hui Ling Shi, Qi Lim, Kah Wai Phan, Anh Tuân |
| author2 | School of Physical and Mathematical Sciences |
| author_facet | School of Physical and Mathematical Sciences Patil, Kiran M. Chin, Danielle Seah, Hui Ling Shi, Qi Lim, Kah Wai Phan, Anh Tuân |
| author_sort | Patil, Kiran M. |
| collection | NTU |
| description | G-quadruplex (G4)-binding proteins regulate important biological processes, but their interaction networks are poorly understood. We report the first use of G4 as warhead of a proteolysis-targeting chimera (G4-PROTAC) for targeted degradation of a G4-binding protein (RHAU/DHX36). G4-PROTAC provides a new way to explore G4-protein networks and to develop potential therapeutics. |
| first_indexed | 2025-02-19T04:02:29Z |
| format | Journal Article |
| id | ntu-10356/158329 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2025-02-19T04:02:29Z |
| publishDate | 2022 |
| record_format | dspace |
| spelling | ntu-10356/1583292023-02-28T20:03:50Z G4-PROTAC: targeted degradation of a G-quadruplex binding protein Patil, Kiran M. Chin, Danielle Seah, Hui Ling Shi, Qi Lim, Kah Wai Phan, Anh Tuân School of Physical and Mathematical Sciences NTU Institute of Structural Biology Science::Biological sciences Science::Chemistry Guanine Quadruplex Binding Proteins G-quadruplex (G4)-binding proteins regulate important biological processes, but their interaction networks are poorly understood. We report the first use of G4 as warhead of a proteolysis-targeting chimera (G4-PROTAC) for targeted degradation of a G4-binding protein (RHAU/DHX36). G4-PROTAC provides a new way to explore G4-protein networks and to develop potential therapeutics. Ministry of Education (MOE) National Research Foundation (NRF) Submitted/Accepted version This research was supported by Singapore Ministry of Education (MOE) Academic Research Fund Tier 2 (MOE2018-T2-2- 029) and the Singapore National Research Foundation Investigatorship (NRF-NRFI2017-09) to A. T. P. 2022-05-18T04:45:31Z 2022-05-18T04:45:31Z 2021 Journal Article Patil, K. M., Chin, D., Seah, H. L., Shi, Q., Lim, K. W. & Phan, A. T. (2021). G4-PROTAC: targeted degradation of a G-quadruplex binding protein. Chemical Communications, 57(95), 12816-12819. https://dx.doi.org/10.1039/d1cc05025g 1359-7345 https://hdl.handle.net/10356/158329 10.1039/d1cc05025g 95 57 12816 12819 en MOE2018-T2-2- 029 Chemical Communications © 2021 The Royal Society of Chemistry. All rights reserved. This paper was published in Chemical Communications and is made available with permission of The Royal Society of Chemistry. application/pdf |
| spellingShingle | Science::Biological sciences Science::Chemistry Guanine Quadruplex Binding Proteins Patil, Kiran M. Chin, Danielle Seah, Hui Ling Shi, Qi Lim, Kah Wai Phan, Anh Tuân G4-PROTAC: targeted degradation of a G-quadruplex binding protein |
| title | G4-PROTAC: targeted degradation of a G-quadruplex binding protein |
| title_full | G4-PROTAC: targeted degradation of a G-quadruplex binding protein |
| title_fullStr | G4-PROTAC: targeted degradation of a G-quadruplex binding protein |
| title_full_unstemmed | G4-PROTAC: targeted degradation of a G-quadruplex binding protein |
| title_short | G4-PROTAC: targeted degradation of a G-quadruplex binding protein |
| title_sort | g4 protac targeted degradation of a g quadruplex binding protein |
| topic | Science::Biological sciences Science::Chemistry Guanine Quadruplex Binding Proteins |
| url | https://hdl.handle.net/10356/158329 |
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