Microbiota regulates the turnover kinetics of gut macrophages in health and inflammation
The gut immune system has evolved to co-exist in a mutually beneficial symbiotic relationship with its microflora. Here, using a germ-free fate-mapping mouse model, we provide clear insight into how the enteric commensals determine the kinetics of macrophage turnover. The microbiome density along th...
| Main Authors: | , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2022
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/159288 |
| _version_ | 1826112841709518848 |
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| author | Chen, Qi Nair, Sajith Ruedl, Christiane |
| author2 | School of Biological Sciences |
| author_facet | School of Biological Sciences Chen, Qi Nair, Sajith Ruedl, Christiane |
| author_sort | Chen, Qi |
| collection | NTU |
| description | The gut immune system has evolved to co-exist in a mutually beneficial symbiotic relationship with its microflora. Here, using a germ-free fate-mapping mouse model, we provide clear insight into how the enteric commensals determine the kinetics of macrophage turnover. The microbiome density along the gastrointestinal tract defines the persistence of ontogenically diverse macrophages, with the highest numbers of the long-lived F4/80hiTim4+ macrophage subset in the less densely colonized small intestine. Furthermore, the microbiome contributes to a tightly regulated monocyte-dependent replenishment of both long- and short-lived F4/80hi macrophages under homeostatic and inflammatory conditions. In the latter situation, the commensals regulate rapid replenishment of the depleted macrophage niche caused by the intestinal inflammation. The microbial ecosystem imprints a favorable cytokine microenvironment in the intestine to support macrophage survival and monocyte-dependent replenishment. Therefore, the host immune system-commensal cross-talk provides an efficient strategy to assure intestinal homeostasis. |
| first_indexed | 2024-10-01T03:13:43Z |
| format | Journal Article |
| id | ntu-10356/159288 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T03:13:43Z |
| publishDate | 2022 |
| record_format | dspace |
| spelling | ntu-10356/1592882023-02-28T17:11:50Z Microbiota regulates the turnover kinetics of gut macrophages in health and inflammation Chen, Qi Nair, Sajith Ruedl, Christiane School of Biological Sciences Science::Biological sciences Biological Marker Cytokine The gut immune system has evolved to co-exist in a mutually beneficial symbiotic relationship with its microflora. Here, using a germ-free fate-mapping mouse model, we provide clear insight into how the enteric commensals determine the kinetics of macrophage turnover. The microbiome density along the gastrointestinal tract defines the persistence of ontogenically diverse macrophages, with the highest numbers of the long-lived F4/80hiTim4+ macrophage subset in the less densely colonized small intestine. Furthermore, the microbiome contributes to a tightly regulated monocyte-dependent replenishment of both long- and short-lived F4/80hi macrophages under homeostatic and inflammatory conditions. In the latter situation, the commensals regulate rapid replenishment of the depleted macrophage niche caused by the intestinal inflammation. The microbial ecosystem imprints a favorable cytokine microenvironment in the intestine to support macrophage survival and monocyte-dependent replenishment. Therefore, the host immune system-commensal cross-talk provides an efficient strategy to assure intestinal homeostasis. Ministry of Education (MOE) Published version This work was supported by a Ministry of Education Tier1 grant awarded to C Ruedl. 2022-06-10T05:50:12Z 2022-06-10T05:50:12Z 2022 Journal Article Chen, Q., Nair, S. & Ruedl, C. (2022). Microbiota regulates the turnover kinetics of gut macrophages in health and inflammation. Life Science Alliance, 5(1), e202101178-. https://dx.doi.org/10.26508/lsa.202101178 2575-1077 https://hdl.handle.net/10356/159288 10.26508/lsa.202101178 34728557 1 5 e202101178 en Life Science Alliance 10.21979/N9/XBXJPP © 2021 Chen et al. This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/). application/pdf |
| spellingShingle | Science::Biological sciences Biological Marker Cytokine Chen, Qi Nair, Sajith Ruedl, Christiane Microbiota regulates the turnover kinetics of gut macrophages in health and inflammation |
| title | Microbiota regulates the turnover kinetics of gut macrophages in health and inflammation |
| title_full | Microbiota regulates the turnover kinetics of gut macrophages in health and inflammation |
| title_fullStr | Microbiota regulates the turnover kinetics of gut macrophages in health and inflammation |
| title_full_unstemmed | Microbiota regulates the turnover kinetics of gut macrophages in health and inflammation |
| title_short | Microbiota regulates the turnover kinetics of gut macrophages in health and inflammation |
| title_sort | microbiota regulates the turnover kinetics of gut macrophages in health and inflammation |
| topic | Science::Biological sciences Biological Marker Cytokine |
| url | https://hdl.handle.net/10356/159288 |
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