Comparison of mental-physical comorbidity, risk of death and mortality among patients with mental disorders - a retrospective cohort study
Aim: To compare the risk of death, the prevalence of comorbid chronic physical illness and mortality among an Asian population of patients with mental disorders. Methods: This was a retrospective data analysing of medical records of patients with schizophrenia, depression, anxiety, bipolar disorder...
| Main Authors: | , , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
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2022
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| Online Access: | https://hdl.handle.net/10356/159562 |
| _version_ | 1824456309965062144 |
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| author | Tan, Xiao Wei Lee, Eng Sing Toh, Matthias Paul Han Sim Lum, Alvin Wai Mun Seah, Darren Ee Jin Leong, Khai Pang Chan, Christopher Yi Wen Fung, Daniel Shuen Sheng Tor, Phern Chern |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Tan, Xiao Wei Lee, Eng Sing Toh, Matthias Paul Han Sim Lum, Alvin Wai Mun Seah, Darren Ee Jin Leong, Khai Pang Chan, Christopher Yi Wen Fung, Daniel Shuen Sheng Tor, Phern Chern |
| author_sort | Tan, Xiao Wei |
| collection | NTU |
| description | Aim: To compare the risk of death, the prevalence of comorbid chronic physical illness and mortality among an Asian population of patients with mental disorders.
Methods: This was a retrospective data analysing of medical records of patients with schizophrenia, depression, anxiety, bipolar disorder, alcohol use disorder (AUD) or substance use disorder and the comorbid chronic physical illnesses. The hazard risk of death was calculated with Cox regression and compared between patients with and without comorbid chronic physical illness(es). Odds ratios of specific comorbid chronic physical illness were calculated with logistic regression and mean crude death rate was calculated for patients with different mental disorders.
Results: A total of 56,447 patients with mental disorders were included in the analysis. Compared to patients without comorbid physical illness, patients with mental-physical comorbidity were associated with a higher risk of death [2.36 (2.22–2.52); hazard ratio (95% CI)] and less estimated survival days [2157 (2142–2172) vs 2508 (2504–2513)]. Compared to other mental disorders, those with AUD had the highest prevalence of two or more comorbid chronic physical illnesses and associated with the highest odds of comorbid hypertension, diabetes mellitus, stroke, nephritis, chronic kidney disease, and cancer. The highest one-year crude death rate was similarly observed in patients with AUD.
Conclusions: Mental-physical comorbidity was associated with a higher risk of death compared to patients with mental disorders only. The highest prevalence of mental-physical comorbidity and mortality were observed in patients with AUD. More attention and resources may be needed to tackle the burden of AUD. |
| first_indexed | 2025-02-19T03:52:04Z |
| format | Journal Article |
| id | ntu-10356/159562 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2025-02-19T03:52:04Z |
| publishDate | 2022 |
| record_format | dspace |
| spelling | ntu-10356/1595622022-06-28T00:34:37Z Comparison of mental-physical comorbidity, risk of death and mortality among patients with mental disorders - a retrospective cohort study Tan, Xiao Wei Lee, Eng Sing Toh, Matthias Paul Han Sim Lum, Alvin Wai Mun Seah, Darren Ee Jin Leong, Khai Pang Chan, Christopher Yi Wen Fung, Daniel Shuen Sheng Tor, Phern Chern Lee Kong Chian School of Medicine (LKCMedicine) National Healthcare Group Polyclinics Institute of Mental Health Duke-NUS Graduate Medical School Science::Medicine Mental Disorders Chronic Physical Illness Aim: To compare the risk of death, the prevalence of comorbid chronic physical illness and mortality among an Asian population of patients with mental disorders. Methods: This was a retrospective data analysing of medical records of patients with schizophrenia, depression, anxiety, bipolar disorder, alcohol use disorder (AUD) or substance use disorder and the comorbid chronic physical illnesses. The hazard risk of death was calculated with Cox regression and compared between patients with and without comorbid chronic physical illness(es). Odds ratios of specific comorbid chronic physical illness were calculated with logistic regression and mean crude death rate was calculated for patients with different mental disorders. Results: A total of 56,447 patients with mental disorders were included in the analysis. Compared to patients without comorbid physical illness, patients with mental-physical comorbidity were associated with a higher risk of death [2.36 (2.22–2.52); hazard ratio (95% CI)] and less estimated survival days [2157 (2142–2172) vs 2508 (2504–2513)]. Compared to other mental disorders, those with AUD had the highest prevalence of two or more comorbid chronic physical illnesses and associated with the highest odds of comorbid hypertension, diabetes mellitus, stroke, nephritis, chronic kidney disease, and cancer. The highest one-year crude death rate was similarly observed in patients with AUD. Conclusions: Mental-physical comorbidity was associated with a higher risk of death compared to patients with mental disorders only. The highest prevalence of mental-physical comorbidity and mortality were observed in patients with AUD. More attention and resources may be needed to tackle the burden of AUD. 2022-06-28T00:34:36Z 2022-06-28T00:34:36Z 2021 Journal Article Tan, X. W., Lee, E. S., Toh, M. P. H. S., Lum, A. W. M., Seah, D. E. J., Leong, K. P., Chan, C. Y. W., Fung, D. S. S. & Tor, P. C. (2021). Comparison of mental-physical comorbidity, risk of death and mortality among patients with mental disorders - a retrospective cohort study. Journal of Psychiatric Research, 142, 48-53. https://dx.doi.org/10.1016/j.jpsychires.2021.07.039 0022-3956 https://hdl.handle.net/10356/159562 10.1016/j.jpsychires.2021.07.039 34320455 2-s2.0-85111006102 142 48 53 en Journal of Psychiatric Research © 2021 Elsevier Ltd. All rights reserved. |
| spellingShingle | Science::Medicine Mental Disorders Chronic Physical Illness Tan, Xiao Wei Lee, Eng Sing Toh, Matthias Paul Han Sim Lum, Alvin Wai Mun Seah, Darren Ee Jin Leong, Khai Pang Chan, Christopher Yi Wen Fung, Daniel Shuen Sheng Tor, Phern Chern Comparison of mental-physical comorbidity, risk of death and mortality among patients with mental disorders - a retrospective cohort study |
| title | Comparison of mental-physical comorbidity, risk of death and mortality among patients with mental disorders - a retrospective cohort study |
| title_full | Comparison of mental-physical comorbidity, risk of death and mortality among patients with mental disorders - a retrospective cohort study |
| title_fullStr | Comparison of mental-physical comorbidity, risk of death and mortality among patients with mental disorders - a retrospective cohort study |
| title_full_unstemmed | Comparison of mental-physical comorbidity, risk of death and mortality among patients with mental disorders - a retrospective cohort study |
| title_short | Comparison of mental-physical comorbidity, risk of death and mortality among patients with mental disorders - a retrospective cohort study |
| title_sort | comparison of mental physical comorbidity risk of death and mortality among patients with mental disorders a retrospective cohort study |
| topic | Science::Medicine Mental Disorders Chronic Physical Illness |
| url | https://hdl.handle.net/10356/159562 |
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