A PDZ protein GIPC3 positively modulates hedgehog signaling and melanoma growth
The hedgehog (Hh) pathway is essential for animal development, but aberrant activation promotes cancer growth. In this study, we show that GIPC3, a PDZ domain-containing protein with putative adaptor protein function, positively modulates Hh target gene expression in normal fibroblasts and melanoma...
Main Authors: | Patmanathan, Sathya Narayanan, Tong, Bing Teck, Teo, Jackie Jia Hao, Ting, Jonathan Yong Zheng, Tan, Nguan Soon, Sim, Kenice Siew Hoon, Ta, Yng-Cun, Woo, Wei-Meng |
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Other Authors: | Lee Kong Chian School of Medicine (LKCMedicine) |
Format: | Journal Article |
Language: | English |
Published: |
2022
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Subjects: | |
Online Access: | https://hdl.handle.net/10356/159770 |
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