A PDZ protein GIPC3 positively modulates hedgehog signaling and melanoma growth

A PDZ protein GIPC3 positively modulates hedgehog signaling and melanoma growth

The hedgehog (Hh) pathway is essential for animal development, but aberrant activation promotes cancer growth. In this study, we show that GIPC3, a PDZ domain-containing protein with putative adaptor protein function, positively modulates Hh target gene expression in normal fibroblasts and melanoma...

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Bibliographic Details
Main Authors: Patmanathan, Sathya Narayanan, Tong, Bing Teck, Teo, Jackie Jia Hao, Ting, Jonathan Yong Zheng, Tan, Nguan Soon, Sim, Kenice Siew Hoon, Ta, Yng-Cun, Woo, Wei-Meng
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Journal Article
Language:English
Published: 2022
Subjects:
Science::Medicine
Primary Cilia
Molecular-Cloning
Online Access:https://hdl.handle.net/10356/159770

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