Mechanisms of cancer transdifferentiation
During cancer progression, cells undergo cell state changes, which contribute towards malignancy, tumor growth and metastasis. Cell state transitions in cancer occurs when cells either undergo epithelial-to-mesenchymal transition (EMT) to become more cellularly plastic in the mesenchymal state or un...
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Thesis-Doctor of Philosophy |
| Language: | English |
| Published: |
Nanyang Technological University
2022
|
| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/159930 |
| _version_ | 1824456332053315584 |
|---|---|
| author | Lee, Jane Jia Hui |
| author2 | Tan Nguan Soon |
| author_facet | Tan Nguan Soon Lee, Jane Jia Hui |
| author_sort | Lee, Jane Jia Hui |
| collection | NTU |
| description | During cancer progression, cells undergo cell state changes, which contribute towards malignancy, tumor growth and metastasis. Cell state transitions in cancer occurs when cells either undergo epithelial-to-mesenchymal transition (EMT) to become more cellularly plastic in the mesenchymal state or undergo mesenchymal-to-epithelial transition (MET) to revert back into the highly proliferative epithelial state. The ability of cancer cells to readily undergo cell state changes attributes significantly to tumor aggression. The perturbation of cell state transitions, therefore, represents an attractive strategy for cancer therapeutics. Current approaches in cancer therapeutics focuses on blocking EMT, thereby preventing metastasis and relapse, or inducing MET, which converts the treatment-resistant mesenchymal cells back into a treatment-sensitive epithelial state. However, transdifferentiation in cancer is a new frontier in cellular differentiation, which could potentially ablate the metastatic capabilities and stump tumor growth in these cancer cells. Thus, highlighting the clinical potential of transdifferentiation in cancer. |
| first_indexed | 2025-02-19T03:52:25Z |
| format | Thesis-Doctor of Philosophy |
| id | ntu-10356/159930 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2025-02-19T03:52:25Z |
| publishDate | 2022 |
| publisher | Nanyang Technological University |
| record_format | dspace |
| spelling | ntu-10356/1599302023-02-28T18:51:06Z Mechanisms of cancer transdifferentiation Lee, Jane Jia Hui Tan Nguan Soon School of Biological Sciences Tam Wai Leong tamwl@gis.a-star.edu.sg, NSTan@ntu.edu.sg Science::Biological sciences During cancer progression, cells undergo cell state changes, which contribute towards malignancy, tumor growth and metastasis. Cell state transitions in cancer occurs when cells either undergo epithelial-to-mesenchymal transition (EMT) to become more cellularly plastic in the mesenchymal state or undergo mesenchymal-to-epithelial transition (MET) to revert back into the highly proliferative epithelial state. The ability of cancer cells to readily undergo cell state changes attributes significantly to tumor aggression. The perturbation of cell state transitions, therefore, represents an attractive strategy for cancer therapeutics. Current approaches in cancer therapeutics focuses on blocking EMT, thereby preventing metastasis and relapse, or inducing MET, which converts the treatment-resistant mesenchymal cells back into a treatment-sensitive epithelial state. However, transdifferentiation in cancer is a new frontier in cellular differentiation, which could potentially ablate the metastatic capabilities and stump tumor growth in these cancer cells. Thus, highlighting the clinical potential of transdifferentiation in cancer. Doctor of Philosophy 2022-07-06T01:42:38Z 2022-07-06T01:42:38Z 2021 Thesis-Doctor of Philosophy Lee, J. J. H. (2021). Mechanisms of cancer transdifferentiation. Doctoral thesis, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/159930 https://hdl.handle.net/10356/159930 10.32657/10356/159930 en This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0). application/pdf Nanyang Technological University |
| spellingShingle | Science::Biological sciences Lee, Jane Jia Hui Mechanisms of cancer transdifferentiation |
| title | Mechanisms of cancer transdifferentiation |
| title_full | Mechanisms of cancer transdifferentiation |
| title_fullStr | Mechanisms of cancer transdifferentiation |
| title_full_unstemmed | Mechanisms of cancer transdifferentiation |
| title_short | Mechanisms of cancer transdifferentiation |
| title_sort | mechanisms of cancer transdifferentiation |
| topic | Science::Biological sciences |
| url | https://hdl.handle.net/10356/159930 |
| work_keys_str_mv | AT leejanejiahui mechanismsofcancertransdifferentiation |