Photoinitiated stereoselective direct C(sp²)–H perfluoroalkylation and difluoroacetylation of enamides

Photoinitiated stereoselective direct C(sp²)–H perfluoroalkylation and difluoroacetylation of enamides

A photoinitiated perfluoroalkylative coupling of enamides with perfluoroalkyl iodides and a visible-light-induced difluoroacetylation of enamides with ethyl bromodifluoroacetate have been developed, respectively. These transformations allow the efficacious and straightforward incorporation of biolog...

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Bibliographic Details
Main Authors: Zhao, Kai, Guo, Jing-Yu, Guan, Ting, Wang, Ying-Xue, Tao, Ji-Yu, Zhang, Yu, Zhang, Qing-Hong, Ni, Kun, Loh, Teck-Peng
Other Authors: School of Physical and Mathematical Sciences
Format: Journal Article
Language:English
Published: 2022
Subjects:
Science::Chemistry
Photoredox Catalysis
Unactivated Alkenes
Online Access:https://hdl.handle.net/10356/159997
Description
Summary:A photoinitiated perfluoroalkylative coupling of enamides with perfluoroalkyl iodides and a visible-light-induced difluoroacetylation of enamides with ethyl bromodifluoroacetate have been developed, respectively. These transformations allow the efficacious and straightforward incorporation of biologically and physiologically privileged fluoro-containing moieties into synthetically eminent enamide scaffolds with excellent regio- and stereoselectivities under mild and environmentally friendly conditions.

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