Insights into potential causes of vascular hyperpermeability in dengue
Dengue is a mosquito-borne disease caused by dengue virus (DENV), where four serotypes can infect humans. Most DENV infections are self-resolving, but in some individuals, severe dengue characterised by a sudden increase in haematocrit, rapid decrease in platelet counts, and vascular leakage is a...
| Main Authors: | , , , |
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| Format: | Journal Article |
| Language: | English |
| Published: |
2022
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| Online Access: | https://hdl.handle.net/10356/160185 |
| _version_ | 1811688311597563904 |
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| author | Teo, Andrew Chua, Caroline Lin Lin Chia, Po Ying Yeo, Tsin Wen |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Teo, Andrew Chua, Caroline Lin Lin Chia, Po Ying Yeo, Tsin Wen |
| author_sort | Teo, Andrew |
| collection | NTU |
| description | Dengue is a mosquito-borne disease caused by dengue virus (DENV), where four serotypes
can infect humans. Most DENV infections are self-resolving, but in some individuals, severe
dengue characterised by a sudden increase in haematocrit, rapid decrease in platelet counts,
and vascular leakage is a complication [1,2]. In severe dengue, a major pathogenic mechanism
is a transient increase in vascular permeability resulting in severe plasma leakage (herein
referred to vascular hyperpermeability) leading to hypotension, circulatory collapse, and organ
dysfunction [1]. The precise mechanism in DENV-associated vascular hyperpermeability is
unclear, and several hypotheses including antibody-dependent enhancement (ADE) and
“cytokine storm” have been proposed. In ADE, suboptimal DENV neutralising antibodies
against a heterologous serotype (in secondary infection) promotes DENV uptake into immunological
cells, increasing infection and viral replication that can exacerbate the immune
response [3]. Similarly, infected monocytes release excessive amounts of proinflammatory
cytokines and, if dysregulated, can lead to “cytokine storm” [4]. In this article, we present current
understandings on the potential causes of dengue-associated vascular hyperpermeability,
which is a consequence of complex interactions between the virus and the host endothelium
immune response. |
| first_indexed | 2024-10-01T05:30:12Z |
| format | Journal Article |
| id | ntu-10356/160185 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T05:30:12Z |
| publishDate | 2022 |
| record_format | dspace |
| spelling | ntu-10356/1601852023-03-05T16:53:54Z Insights into potential causes of vascular hyperpermeability in dengue Teo, Andrew Chua, Caroline Lin Lin Chia, Po Ying Yeo, Tsin Wen Lee Kong Chian School of Medicine (LKCMedicine) National Centre for Infectious Diseases Tan Tock Seng Hospital Science::Medicine Dengue Blood Vessel Permeability Dengue is a mosquito-borne disease caused by dengue virus (DENV), where four serotypes can infect humans. Most DENV infections are self-resolving, but in some individuals, severe dengue characterised by a sudden increase in haematocrit, rapid decrease in platelet counts, and vascular leakage is a complication [1,2]. In severe dengue, a major pathogenic mechanism is a transient increase in vascular permeability resulting in severe plasma leakage (herein referred to vascular hyperpermeability) leading to hypotension, circulatory collapse, and organ dysfunction [1]. The precise mechanism in DENV-associated vascular hyperpermeability is unclear, and several hypotheses including antibody-dependent enhancement (ADE) and “cytokine storm” have been proposed. In ADE, suboptimal DENV neutralising antibodies against a heterologous serotype (in secondary infection) promotes DENV uptake into immunological cells, increasing infection and viral replication that can exacerbate the immune response [3]. Similarly, infected monocytes release excessive amounts of proinflammatory cytokines and, if dysregulated, can lead to “cytokine storm” [4]. In this article, we present current understandings on the potential causes of dengue-associated vascular hyperpermeability, which is a consequence of complex interactions between the virus and the host endothelium immune response. Nanyang Technological University National Medical Research Council (NMRC) Published version AT is supported by Nanyang Technological University Research Scholarship Block Fellowship of Singapore and Lee Kong Chian School of Medicine, Singapore, Start-up grant. CLLC receives support from Ministry of Education (MOE) Fundamental Research Grant Scheme of Malaysia: ID FRGS/1/2020/SKK0/TAYLOR/02/1. PYC is supported by NMRC Research Training Fellowship (NMRC/Fellowship/0056/2018). TWY is supported by Lee Kong Chian School of Medicine Singapore, Start-up grant. 2022-07-14T06:26:35Z 2022-07-14T06:26:35Z 2021 Journal Article Teo, A., Chua, C. L. L., Chia, P. Y. & Yeo, T. W. (2021). Insights into potential causes of vascular hyperpermeability in dengue. PLOS Pathogens, 17(12), e1010065-. https://dx.doi.org/10.1371/journal.ppat.1010065 1553-7366 https://hdl.handle.net/10356/160185 10.1371/journal.ppat.1010065 34882753 2-s2.0-85121307267 12 17 e1010065 en NMRC/Fellowship/0056/2018 PLOS Pathogens © 2021 Teo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. application/pdf |
| spellingShingle | Science::Medicine Dengue Blood Vessel Permeability Teo, Andrew Chua, Caroline Lin Lin Chia, Po Ying Yeo, Tsin Wen Insights into potential causes of vascular hyperpermeability in dengue |
| title | Insights into potential causes of vascular hyperpermeability in dengue |
| title_full | Insights into potential causes of vascular hyperpermeability in dengue |
| title_fullStr | Insights into potential causes of vascular hyperpermeability in dengue |
| title_full_unstemmed | Insights into potential causes of vascular hyperpermeability in dengue |
| title_short | Insights into potential causes of vascular hyperpermeability in dengue |
| title_sort | insights into potential causes of vascular hyperpermeability in dengue |
| topic | Science::Medicine Dengue Blood Vessel Permeability |
| url | https://hdl.handle.net/10356/160185 |
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