A neural circuit for excessive feeding driven by environmental context in mice
Despite notable genetic influences, obesity mainly results from the overconsumption of food, which arises from the interplay of physiological, cognitive and environmental factors. In patients with obesity, eating is determined more by external cues than by internal physiological needs. However, how...
| Main Authors: | , , , , , , , , , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2022
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/160484 |
| _version_ | 1824453357749665792 |
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| author | Mohammad, Hasan Senol, Esra Graf, Martin Lee, Chun-Yao Li, Qin Liu, Qing Yeo, Xin Yi Wang, Menghan Laskaratos, Achilleas Xu, Fuqiang Luo, Sarah Xinwei Jung, Sangyong Augustine, George James Fu, Yu |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Mohammad, Hasan Senol, Esra Graf, Martin Lee, Chun-Yao Li, Qin Liu, Qing Yeo, Xin Yi Wang, Menghan Laskaratos, Achilleas Xu, Fuqiang Luo, Sarah Xinwei Jung, Sangyong Augustine, George James Fu, Yu |
| author_sort | Mohammad, Hasan |
| collection | NTU |
| description | Despite notable genetic influences, obesity mainly results from the overconsumption of food, which arises from the interplay of physiological, cognitive and environmental factors. In patients with obesity, eating is determined more by external cues than by internal physiological needs. However, how environmental context drives non-homeostatic feeding is elusive. Here, we identify a population of somatostatin (TNSST) neurons in the mouse hypothalamic tuberal nucleus that are preferentially activated by palatable food. Activation of TNSST neurons enabled a context to drive non-homeostatic feeding in sated mice and required inputs from the subiculum. Pairing a context with palatable food greatly potentiated synaptic transmission between the subiculum and TNSST neurons and drove non-homeostatic feeding that could be selectively suppressed by inhibiting TNSST neurons or the subiculum but not other major orexigenic neurons. These results reveal how palatable food, through a specific hypothalamic circuit, empowers environmental context to drive non-homeostatic feeding. |
| first_indexed | 2024-10-01T07:59:05Z |
| format | Journal Article |
| id | ntu-10356/160484 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:59:05Z |
| publishDate | 2022 |
| record_format | dspace |
| spelling | ntu-10356/1604842022-07-25T06:13:10Z A neural circuit for excessive feeding driven by environmental context in mice Mohammad, Hasan Senol, Esra Graf, Martin Lee, Chun-Yao Li, Qin Liu, Qing Yeo, Xin Yi Wang, Menghan Laskaratos, Achilleas Xu, Fuqiang Luo, Sarah Xinwei Jung, Sangyong Augustine, George James Fu, Yu Lee Kong Chian School of Medicine (LKCMedicine) Science::Medicine Medial Prefrontal Cortex Gabaergic Neurons Despite notable genetic influences, obesity mainly results from the overconsumption of food, which arises from the interplay of physiological, cognitive and environmental factors. In patients with obesity, eating is determined more by external cues than by internal physiological needs. However, how environmental context drives non-homeostatic feeding is elusive. Here, we identify a population of somatostatin (TNSST) neurons in the mouse hypothalamic tuberal nucleus that are preferentially activated by palatable food. Activation of TNSST neurons enabled a context to drive non-homeostatic feeding in sated mice and required inputs from the subiculum. Pairing a context with palatable food greatly potentiated synaptic transmission between the subiculum and TNSST neurons and drove non-homeostatic feeding that could be selectively suppressed by inhibiting TNSST neurons or the subiculum but not other major orexigenic neurons. These results reveal how palatable food, through a specific hypothalamic circuit, empowers environmental context to drive non-homeostatic feeding. Agency for Science, Technology and Research (A*STAR) Ministry of Education (MOE) This work was supported by an A*STAR Investigatorship provided by the Biomedical Research Council (BMRC) of A*STAR (1530700142 to Y.F.), the Singapore Ministry of Education (MOE2017-T3-1-002 to G.J.A.) and the National Natural Science Foundation of China (31900708 to Q. Li). E.S. is supported by a SINGA graduate scholarship from the A*STAR Graduate Academy. 2022-07-25T06:13:10Z 2022-07-25T06:13:10Z 2021 Journal Article Mohammad, H., Senol, E., Graf, M., Lee, C., Li, Q., Liu, Q., Yeo, X. Y., Wang, M., Laskaratos, A., Xu, F., Luo, S. X., Jung, S., Augustine, G. J. & Fu, Y. (2021). A neural circuit for excessive feeding driven by environmental context in mice. Nature Neuroscience, 24(8), 1132-1141. https://dx.doi.org/10.1038/s41593-021-00875-9 1097-6256 https://hdl.handle.net/10356/160484 10.1038/s41593-021-00875-9 34168339 2-s2.0-85108423025 8 24 1132 1141 en 1530700142 MOE2017-T3-1-002 Nature Neuroscience © 2021 The Author(s), under exclusive licence to Springer Nature America, Inc. All rights reserved. |
| spellingShingle | Science::Medicine Medial Prefrontal Cortex Gabaergic Neurons Mohammad, Hasan Senol, Esra Graf, Martin Lee, Chun-Yao Li, Qin Liu, Qing Yeo, Xin Yi Wang, Menghan Laskaratos, Achilleas Xu, Fuqiang Luo, Sarah Xinwei Jung, Sangyong Augustine, George James Fu, Yu A neural circuit for excessive feeding driven by environmental context in mice |
| title | A neural circuit for excessive feeding driven by environmental context in mice |
| title_full | A neural circuit for excessive feeding driven by environmental context in mice |
| title_fullStr | A neural circuit for excessive feeding driven by environmental context in mice |
| title_full_unstemmed | A neural circuit for excessive feeding driven by environmental context in mice |
| title_short | A neural circuit for excessive feeding driven by environmental context in mice |
| title_sort | neural circuit for excessive feeding driven by environmental context in mice |
| topic | Science::Medicine Medial Prefrontal Cortex Gabaergic Neurons |
| url | https://hdl.handle.net/10356/160484 |
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