Genomic basis of striking fin shapes and colors in the fighting fish
Resolving the genomic basis underlying phenotypic variations is a question of great importance in evolutionary biology. However, understanding how genotypes determine the phenotypes is still challenging. Centuries of artificial selective breeding for beauty and aggression resulted in a plethora of c...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
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2022
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| Online Access: | https://hdl.handle.net/10356/160504 |
| _version_ | 1826119074512371712 |
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| author | Wang, Le Sun, Fei Wan, Zi Yi Ye, Baoqing Wen, Yanfei Liu, Huiming Yang, Zituo Pang, Hongyan Meng, Zining Fan, Bin Alfiko, Yuzer Shen, Yubang Bai, Bin Lee, May Shu Qing Piferrer, Francesc Schartl, Manfred Meyer, Axel Yue, Gen Hua |
| author2 | School of Biological Sciences |
| author_facet | School of Biological Sciences Wang, Le Sun, Fei Wan, Zi Yi Ye, Baoqing Wen, Yanfei Liu, Huiming Yang, Zituo Pang, Hongyan Meng, Zining Fan, Bin Alfiko, Yuzer Shen, Yubang Bai, Bin Lee, May Shu Qing Piferrer, Francesc Schartl, Manfred Meyer, Axel Yue, Gen Hua |
| author_sort | Wang, Le |
| collection | NTU |
| description | Resolving the genomic basis underlying phenotypic variations is a question of great importance in evolutionary biology. However, understanding how genotypes determine the phenotypes is still challenging. Centuries of artificial selective breeding for beauty and aggression resulted in a plethora of colors, long-fin varieties, and hyper-aggressive behavior in the air-breathing Siamese fighting fish (Betta splendens), supplying an excellent system for studying the genomic basis of phenotypic variations. Combining whole-genome sequencing, quantitative trait loci mapping, genome-wide association studies, and genome editing, we investigated the genomic basis of huge morphological variation in fins and striking differences in coloration in the fighting fish. Results revealed that the double tail, elephant ear, albino, and fin spot mutants each were determined by single major-effect loci. The elephant ear phenotype was likely related to differential expression of a potassium ion channel gene, kcnh8. The albinotic phenotype was likely linked to a cis-regulatory element acting on the mitfa gene and the double-tail mutant was suggested to be caused by a deletion in a zic1/zic4 coenhancer. Our data highlight that major loci and cis-regulatory elements play important roles in bringing about phenotypic innovations and establish Bettas as new powerful model to study the genomic basis of evolved changes. |
| first_indexed | 2024-10-01T04:54:06Z |
| format | Journal Article |
| id | ntu-10356/160504 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:54:06Z |
| publishDate | 2022 |
| record_format | dspace |
| spelling | ntu-10356/1605042023-02-28T17:11:22Z Genomic basis of striking fin shapes and colors in the fighting fish Wang, Le Sun, Fei Wan, Zi Yi Ye, Baoqing Wen, Yanfei Liu, Huiming Yang, Zituo Pang, Hongyan Meng, Zining Fan, Bin Alfiko, Yuzer Shen, Yubang Bai, Bin Lee, May Shu Qing Piferrer, Francesc Schartl, Manfred Meyer, Axel Yue, Gen Hua School of Biological Sciences Science::Biological sciences Domestication Evolution Resolving the genomic basis underlying phenotypic variations is a question of great importance in evolutionary biology. However, understanding how genotypes determine the phenotypes is still challenging. Centuries of artificial selective breeding for beauty and aggression resulted in a plethora of colors, long-fin varieties, and hyper-aggressive behavior in the air-breathing Siamese fighting fish (Betta splendens), supplying an excellent system for studying the genomic basis of phenotypic variations. Combining whole-genome sequencing, quantitative trait loci mapping, genome-wide association studies, and genome editing, we investigated the genomic basis of huge morphological variation in fins and striking differences in coloration in the fighting fish. Results revealed that the double tail, elephant ear, albino, and fin spot mutants each were determined by single major-effect loci. The elephant ear phenotype was likely related to differential expression of a potassium ion channel gene, kcnh8. The albinotic phenotype was likely linked to a cis-regulatory element acting on the mitfa gene and the double-tail mutant was suggested to be caused by a deletion in a zic1/zic4 coenhancer. Our data highlight that major loci and cis-regulatory elements play important roles in bringing about phenotypic innovations and establish Bettas as new powerful model to study the genomic basis of evolved changes. Published version 2022-07-26T02:33:53Z 2022-07-26T02:33:53Z 2021 Journal Article Wang, L., Sun, F., Wan, Z. Y., Ye, B., Wen, Y., Liu, H., Yang, Z., Pang, H., Meng, Z., Fan, B., Alfiko, Y., Shen, Y., Bai, B., Lee, M. S. Q., Piferrer, F., Schartl, M., Meyer, A. & Yue, G. H. (2021). Genomic basis of striking fin shapes and colors in the fighting fish. Molecular Biology and Evolution, 38(8), 3383-3396. https://dx.doi.org/10.1093/molbev/msab110 0737-4038 https://hdl.handle.net/10356/160504 10.1093/molbev/msab110 33871625 2-s2.0-85109759850 8 38 3383 3396 en Molecular Biology and Evolution © 2021 The Author(s). Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/ licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. application/pdf |
| spellingShingle | Science::Biological sciences Domestication Evolution Wang, Le Sun, Fei Wan, Zi Yi Ye, Baoqing Wen, Yanfei Liu, Huiming Yang, Zituo Pang, Hongyan Meng, Zining Fan, Bin Alfiko, Yuzer Shen, Yubang Bai, Bin Lee, May Shu Qing Piferrer, Francesc Schartl, Manfred Meyer, Axel Yue, Gen Hua Genomic basis of striking fin shapes and colors in the fighting fish |
| title | Genomic basis of striking fin shapes and colors in the fighting fish |
| title_full | Genomic basis of striking fin shapes and colors in the fighting fish |
| title_fullStr | Genomic basis of striking fin shapes and colors in the fighting fish |
| title_full_unstemmed | Genomic basis of striking fin shapes and colors in the fighting fish |
| title_short | Genomic basis of striking fin shapes and colors in the fighting fish |
| title_sort | genomic basis of striking fin shapes and colors in the fighting fish |
| topic | Science::Biological sciences Domestication Evolution |
| url | https://hdl.handle.net/10356/160504 |
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