Renal CD169++ resident macrophages are crucial for protection against acute systemic candidiasis
Disseminated candidiasis remains as the most common hospital-acquired bloodstream fungal infection with up to 40% mortality rate despite the advancement of medical and hygienic practices. While it is well established that this infection heavily relies on the innate immune response for host survival,...
| Main Authors: | , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
| Published: |
2022
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| Online Access: | https://hdl.handle.net/10356/160608 |
| _version_ | 1811681600004423680 |
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| author | Teo, Yi Juan Ng, See Liang Mak, Keng Wai Setiagani, Yolanda Aphrilia Chen, Qi Nair, Sajith Kumar Sheng, Jianpeng Ruedl, Christiane |
| author2 | School of Biological Sciences |
| author_facet | School of Biological Sciences Teo, Yi Juan Ng, See Liang Mak, Keng Wai Setiagani, Yolanda Aphrilia Chen, Qi Nair, Sajith Kumar Sheng, Jianpeng Ruedl, Christiane |
| author_sort | Teo, Yi Juan |
| collection | NTU |
| description | Disseminated candidiasis remains as the most common hospital-acquired bloodstream fungal infection with up to 40% mortality rate despite the advancement of medical and hygienic practices. While it is well established that this infection heavily relies on the innate immune response for host survival, much less is known for the protective role elicited by the tissue-resident macrophage (TRM) subsets in the kidney, the prime organ for Candida persistence. Here, we describe a unique CD169++ TRM subset that controls Candida growth and inflammation during acute systemic candidiasis. Their absence causes severe fungal-mediated renal pathology. CD169++ TRMs, without being actively involved in direct fungal clearance, increase host resistance by promoting IFN-γ release and neutrophil ROS activity. |
| first_indexed | 2024-10-01T03:43:31Z |
| format | Journal Article |
| id | ntu-10356/160608 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T03:43:31Z |
| publishDate | 2022 |
| record_format | dspace |
| spelling | ntu-10356/1606082023-02-28T17:12:55Z Renal CD169++ resident macrophages are crucial for protection against acute systemic candidiasis Teo, Yi Juan Ng, See Liang Mak, Keng Wai Setiagani, Yolanda Aphrilia Chen, Qi Nair, Sajith Kumar Sheng, Jianpeng Ruedl, Christiane School of Biological Sciences Science::Biological sciences Candidiasis Acute Disease Disseminated candidiasis remains as the most common hospital-acquired bloodstream fungal infection with up to 40% mortality rate despite the advancement of medical and hygienic practices. While it is well established that this infection heavily relies on the innate immune response for host survival, much less is known for the protective role elicited by the tissue-resident macrophage (TRM) subsets in the kidney, the prime organ for Candida persistence. Here, we describe a unique CD169++ TRM subset that controls Candida growth and inflammation during acute systemic candidiasis. Their absence causes severe fungal-mediated renal pathology. CD169++ TRMs, without being actively involved in direct fungal clearance, increase host resistance by promoting IFN-γ release and neutrophil ROS activity. Ministry of Education (MOE) Published version This work was supported by the Ministry of Education Tier 2 grant (MOE2016-T2-1-012) awarded to C Ruedl. 2022-07-27T08:15:32Z 2022-07-27T08:15:32Z 2021 Journal Article Teo, Y. J., Ng, S. L., Mak, K. W., Setiagani, Y. A., Chen, Q., Nair, S. K., Sheng, J. & Ruedl, C. (2021). Renal CD169++ resident macrophages are crucial for protection against acute systemic candidiasis. Life Science Alliance, 4(5), e202000890-. https://dx.doi.org/10.26508/lsa.202000890 2575-1077 https://hdl.handle.net/10356/160608 10.26508/lsa.202000890 33608410 5 4 e202000890 en MOE2016-T2-1-012 Life science alliance © 2021 Teo et al. This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/). application/pdf |
| spellingShingle | Science::Biological sciences Candidiasis Acute Disease Teo, Yi Juan Ng, See Liang Mak, Keng Wai Setiagani, Yolanda Aphrilia Chen, Qi Nair, Sajith Kumar Sheng, Jianpeng Ruedl, Christiane Renal CD169++ resident macrophages are crucial for protection against acute systemic candidiasis |
| title | Renal CD169++ resident macrophages are crucial for protection against acute systemic candidiasis |
| title_full | Renal CD169++ resident macrophages are crucial for protection against acute systemic candidiasis |
| title_fullStr | Renal CD169++ resident macrophages are crucial for protection against acute systemic candidiasis |
| title_full_unstemmed | Renal CD169++ resident macrophages are crucial for protection against acute systemic candidiasis |
| title_short | Renal CD169++ resident macrophages are crucial for protection against acute systemic candidiasis |
| title_sort | renal cd169 resident macrophages are crucial for protection against acute systemic candidiasis |
| topic | Science::Biological sciences Candidiasis Acute Disease |
| url | https://hdl.handle.net/10356/160608 |
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