A polymer multicellular nanoengager for synergistic NIR-II photothermal immunotherapy
Cell-membrane-coated nanoparticles (CCNPs) that integrate the biophysiological advantages of cell membranes with the multifunctionalities of synthetic materials hold great promise in cancer immunotherapy. However, strategies have yet to be revealed to further improve their immunotherapeutic efficacy...
| Main Authors: | , , , , |
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| Format: | Journal Article |
| Language: | English |
| Published: |
2022
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| Online Access: | https://hdl.handle.net/10356/160722 |
| _version_ | 1826123981070008320 |
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| author | Xu, Cheng Jiang, Yuyan Han, Yahong Pu, Kanyi Zhang, Ruiping |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Xu, Cheng Jiang, Yuyan Han, Yahong Pu, Kanyi Zhang, Ruiping |
| author_sort | Xu, Cheng |
| collection | NTU |
| description | Cell-membrane-coated nanoparticles (CCNPs) that integrate the biophysiological advantages of cell membranes with the multifunctionalities of synthetic materials hold great promise in cancer immunotherapy. However, strategies have yet to be revealed to further improve their immunotherapeutic efficacy. Herein, a polymer multicellular nanoengager (SPNE) for synergistic second-near-infrared-window (NIR-II) photothermal immunotherapy is reported. The nanoengager consists of an NIR-II absorbing polymer as the photothermal core, which is camouflaged with fused membranes derived from immunologically engineered tumor cells and dendritic cells (DCs) as the cancer vaccine shell. In association with the high accumulation in lymph nodes and tumors, the multicellular engagement ability of the SPNE enables effective cross-interactions among tumor cells, DCs, and T cells, leading to augmented T cell activation relative to bare or tumor-cell-coated nanoparticles. Upon deep-tissue penetrating NIR-II photoirradiation, SPNE eradicates the tumor and induces immunogenic cell death, further eliciting anti-tumor T cell immunity. Such a synergistic photothermal immunotherapeutic effect eventually inhibits tumor growth, prevents metastasis and procures immunological memory. Thus, this study presents a general cell-membrane-coating approach to develop photo-immunotherapeutic agents for cancer therapy. |
| first_indexed | 2024-10-01T06:13:11Z |
| format | Journal Article |
| id | ntu-10356/160722 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:13:11Z |
| publishDate | 2022 |
| record_format | dspace |
| spelling | ntu-10356/1607222022-08-01T08:10:20Z A polymer multicellular nanoengager for synergistic NIR-II photothermal immunotherapy Xu, Cheng Jiang, Yuyan Han, Yahong Pu, Kanyi Zhang, Ruiping School of Chemical and Biomedical Engineering School of Physical and Mathematical Sciences Engineering::Bioengineering Immunotherapy Polymer Nanoparticles Cell-membrane-coated nanoparticles (CCNPs) that integrate the biophysiological advantages of cell membranes with the multifunctionalities of synthetic materials hold great promise in cancer immunotherapy. However, strategies have yet to be revealed to further improve their immunotherapeutic efficacy. Herein, a polymer multicellular nanoengager (SPNE) for synergistic second-near-infrared-window (NIR-II) photothermal immunotherapy is reported. The nanoengager consists of an NIR-II absorbing polymer as the photothermal core, which is camouflaged with fused membranes derived from immunologically engineered tumor cells and dendritic cells (DCs) as the cancer vaccine shell. In association with the high accumulation in lymph nodes and tumors, the multicellular engagement ability of the SPNE enables effective cross-interactions among tumor cells, DCs, and T cells, leading to augmented T cell activation relative to bare or tumor-cell-coated nanoparticles. Upon deep-tissue penetrating NIR-II photoirradiation, SPNE eradicates the tumor and induces immunogenic cell death, further eliciting anti-tumor T cell immunity. Such a synergistic photothermal immunotherapeutic effect eventually inhibits tumor growth, prevents metastasis and procures immunological memory. Thus, this study presents a general cell-membrane-coating approach to develop photo-immunotherapeutic agents for cancer therapy. Ministry of Education (MOE) Nanyang Technological University K.P. thanks Nanyang Technological University (Start-Up Grant: M4081627) and Singapore Ministry of Education, Academic Research Fund Tier 1 (2019-T1-002-045, RG125/19) and Academic Research Fund Tier 2 (MOE2018-T2-2-042) for the financial support. R.Z. thanks the financial support from the National Natural Science Foundation of China (Nos. 82071987 and 81771907). 2022-08-01T08:10:17Z 2022-08-01T08:10:17Z 2021 Journal Article Xu, C., Jiang, Y., Han, Y., Pu, K. & Zhang, R. (2021). A polymer multicellular nanoengager for synergistic NIR-II photothermal immunotherapy. Advanced Materials, 33(14), 2008061-. https://dx.doi.org/10.1002/adma.202008061 0935-9648 https://hdl.handle.net/10356/160722 10.1002/adma.202008061 33634897 2-s2.0-85101650428 14 33 2008061 en M4081627 2019-T1-002-045 RG125/19 MOE2018-T2-2-042 Advanced Materials © 2021 Wiley-VCH GmbH. All rights reserved. |
| spellingShingle | Engineering::Bioengineering Immunotherapy Polymer Nanoparticles Xu, Cheng Jiang, Yuyan Han, Yahong Pu, Kanyi Zhang, Ruiping A polymer multicellular nanoengager for synergistic NIR-II photothermal immunotherapy |
| title | A polymer multicellular nanoengager for synergistic NIR-II photothermal immunotherapy |
| title_full | A polymer multicellular nanoengager for synergistic NIR-II photothermal immunotherapy |
| title_fullStr | A polymer multicellular nanoengager for synergistic NIR-II photothermal immunotherapy |
| title_full_unstemmed | A polymer multicellular nanoengager for synergistic NIR-II photothermal immunotherapy |
| title_short | A polymer multicellular nanoengager for synergistic NIR-II photothermal immunotherapy |
| title_sort | polymer multicellular nanoengager for synergistic nir ii photothermal immunotherapy |
| topic | Engineering::Bioengineering Immunotherapy Polymer Nanoparticles |
| url | https://hdl.handle.net/10356/160722 |
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