HNRNPM controls circRNA biogenesis and splicing fidelity to sustain cancer cell fitness

HNRNPM controls circRNA biogenesis and splicing fidelity to sustain cancer cell fitness

High spliceosome activity is a dependency for cancer cells, making them more vulnerable to perturbation of the splicing machinery compared to normal cells. To identify splicing factors important for prostate cancer (PCa) fitness, we performed pooled shRNA screens in vitro and in vivo. Our screens id...

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Bibliographic Details
Main Authors: Ho, Jessica S. Y., Di Tullio, Federico, Schwarz, Megan, Low, Diana, Incarnato, Danny, Gay, Florence, Tabaglio, Tommaso, Zhang, Jingxian, Wollmann, Heike, Chen, Leilei, An, Omer, Chan, Tim Hon Man, Hickman, Alexander Hall, Zheng, Simin, Roudko, Vladimir, Chen, Sujun, Karz, Alcida, Ahmed, Musaddeque, He, Hansen Housheng, Greenbaum, Benjamin D., Oliviero, Salvatore, Serresi, Michela, Gargiulo, Gaetano, Mann, Karen M., Hernando, Eva, Mulholland, David, Marazzi, Ivan, Wee, Dave Keng Boon, Guccione, Ernesto
Other Authors: School of Biological Sciences
Format: Journal Article
Language:English
Published: 2022
Subjects:
Science::Biological sciences
Circular Ribonucleic Acid
Animal Experiment
Online Access:https://hdl.handle.net/10356/160757

Internet

https://hdl.handle.net/10356/160757

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