HNRNPM controls circRNA biogenesis and splicing fidelity to sustain cancer cell fitness
High spliceosome activity is a dependency for cancer cells, making them more vulnerable to perturbation of the splicing machinery compared to normal cells. To identify splicing factors important for prostate cancer (PCa) fitness, we performed pooled shRNA screens in vitro and in vivo. Our screens id...
Main Authors: | Ho, Jessica S. Y., Di Tullio, Federico, Schwarz, Megan, Low, Diana, Incarnato, Danny, Gay, Florence, Tabaglio, Tommaso, Zhang, Jingxian, Wollmann, Heike, Chen, Leilei, An, Omer, Chan, Tim Hon Man, Hickman, Alexander Hall, Zheng, Simin, Roudko, Vladimir, Chen, Sujun, Karz, Alcida, Ahmed, Musaddeque, He, Hansen Housheng, Greenbaum, Benjamin D., Oliviero, Salvatore, Serresi, Michela, Gargiulo, Gaetano, Mann, Karen M., Hernando, Eva, Mulholland, David, Marazzi, Ivan, Wee, Dave Keng Boon, Guccione, Ernesto |
---|---|
Other Authors: | School of Biological Sciences |
Format: | Journal Article |
Language: | English |
Published: |
2022
|
Subjects: | |
Online Access: | https://hdl.handle.net/10356/160757 |
Similar Items
-
miRNA and lncRNA as potential tissue biomarkers in hepatocellular carcinoma
by: Venkata Ramana Mallela, et al.
Published: (2024-03-01) -
Effect of Interleukin 28B SNP rs12979860 Genotype on Viral Load in Hepatitis C Virus in Kolar Population, Karnataka, India
by: Devinder Kaur, et al.
Published: (2022-08-01) -
Circulating serum micro-ribonucleic acids 155 and 205 before and after surgery in patients with breast cancer
by: K Rama, et al.
Published: (2021-01-01) -
Comparison of 16S rRNA Sequencing and VITEK 2 Analysis for the Identification of Acinetobacter baumannii Clinical Isolates: A Study from Southwestern Province of Saudi Arabia
by: Vinod Kumar Basode, et al.
Published: (2024-03-01) -
Micro-ribonucleic acid modulation with oxidative stress and inflammation in patients with type 2 diabetes mellitus – a review article
by: Aleksandra Klisic, et al.
Published: (2022-04-01)