Enhancing K⁺ transport activity and selectivity of synthetic K⁺ channels via electron-donating effects
A minor alteration in structure of a previously reported synthetic K+ channel via replacing the electron-withdrawing group with an electron-donating group leads to enhancement in activity by 160% and in selectivity by >50%. As a result, the new K+ channel 10F5, despite having a simple structure,...
| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2022
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| Online Access: | https://hdl.handle.net/10356/160879 |
| _version_ | 1811680724464435200 |
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| author | Zeng, Landley Ziluo Zhang, Hao Wang, Tianxiang Li, Tianhu |
| author2 | School of Physical and Mathematical Sciences |
| author_facet | School of Physical and Mathematical Sciences Zeng, Landley Ziluo Zhang, Hao Wang, Tianxiang Li, Tianhu |
| author_sort | Zeng, Landley Ziluo |
| collection | NTU |
| description | A minor alteration in structure of a previously reported synthetic K+ channel via replacing the electron-withdrawing group with an electron-donating group leads to enhancement in activity by 160% and in selectivity by >50%. As a result, the new K+ channel 10F5, despite having a simple structure, exhibits a high K+/Na+ selectivity of 14.0. |
| first_indexed | 2024-10-01T03:29:36Z |
| format | Journal Article |
| id | ntu-10356/160879 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T03:29:36Z |
| publishDate | 2022 |
| record_format | dspace |
| spelling | ntu-10356/1608792022-08-05T03:05:21Z Enhancing K⁺ transport activity and selectivity of synthetic K⁺ channels via electron-donating effects Zeng, Landley Ziluo Zhang, Hao Wang, Tianxiang Li, Tianhu School of Physical and Mathematical Sciences Science::Chemistry Room-Temperature Gelation Ion Channels A minor alteration in structure of a previously reported synthetic K+ channel via replacing the electron-withdrawing group with an electron-donating group leads to enhancement in activity by 160% and in selectivity by >50%. As a result, the new K+ channel 10F5, despite having a simple structure, exhibits a high K+/Na+ selectivity of 14.0. Agency for Science, Technology and Research (A*STAR) This work is funded by the Agency for Science, Technology and Research, Singapore (SERC A1883c0007 to T. L.). 2022-08-05T03:05:20Z 2022-08-05T03:05:20Z 2020 Journal Article Zeng, L. Z., Zhang, H., Wang, T. & Li, T. (2020). Enhancing K⁺ transport activity and selectivity of synthetic K⁺ channels via electron-donating effects. Chemical Communications, 56(8), 1211-1214. https://dx.doi.org/10.1039/C9CC08396K 1359-7345 https://hdl.handle.net/10356/160879 10.1039/C9CC08396K 8 56 1211 1214 en A1883c0007 Chemical Communications © 2020 The Royal Society of Chemistry. All rights reserved. |
| spellingShingle | Science::Chemistry Room-Temperature Gelation Ion Channels Zeng, Landley Ziluo Zhang, Hao Wang, Tianxiang Li, Tianhu Enhancing K⁺ transport activity and selectivity of synthetic K⁺ channels via electron-donating effects |
| title | Enhancing K⁺ transport activity and selectivity of synthetic K⁺ channels via electron-donating effects |
| title_full | Enhancing K⁺ transport activity and selectivity of synthetic K⁺ channels via electron-donating effects |
| title_fullStr | Enhancing K⁺ transport activity and selectivity of synthetic K⁺ channels via electron-donating effects |
| title_full_unstemmed | Enhancing K⁺ transport activity and selectivity of synthetic K⁺ channels via electron-donating effects |
| title_short | Enhancing K⁺ transport activity and selectivity of synthetic K⁺ channels via electron-donating effects |
| title_sort | enhancing k⁺ transport activity and selectivity of synthetic k⁺ channels via electron donating effects |
| topic | Science::Chemistry Room-Temperature Gelation Ion Channels |
| url | https://hdl.handle.net/10356/160879 |
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