Efficacy of integrating acupuncture to reduce cancer-related pain: a meta-analysis
Background: Pain is commonly experienced by cancer patients, compromising quality of life. This study aims to investigate the efficacy of acupuncture and identify the acupoints distribution in alleviating cancer-related pain. Methods: Six established databases were searched from inception through...
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| Format: | Final Year Project (FYP) |
| Language: | English |
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Nanyang Technological University
2022
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| Online Access: | https://hdl.handle.net/10356/160882 |
| _version_ | 1811694873585123328 |
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| author | Deng, Grace Zheyun |
| author2 | Zhao Yan |
| author_facet | Zhao Yan Deng, Grace Zheyun |
| author_sort | Deng, Grace Zheyun |
| collection | NTU |
| description | Background: Pain is commonly experienced by cancer patients, compromising quality of life. This study aims to investigate the efficacy of acupuncture and identify the acupoints distribution in alleviating cancer-related pain.
Methods: Six established databases were searched from inception through 25 May 2022. Eligible trials were analyzed using Review Manager 5.4.1. Subgroup analysis was conducted to determine whether any mode of acupuncture or cancer-pain had significantly better efficacy than the rest. R-Studio Version 4.1.1 was used to generate relative frequency plot of highly-used acupoints.
Results: 21 eligible trials covering 1413 participants were included. Meta-analysis revealed that efficacy of acupuncture analgesia was significantly higher than the control [SMD(Standardized mean difference)=0.85, 95%CI(confidence interval)=(0.58,1.13), p<0.00001]. The four therapies showed significant benefit in reducing cancer-pain, where SMD=1.33,95%CI=(0.13,2.53),p=0.03 for moxibustion; SMD=0.97,95%CI=(0.57,1.38),p<0.00001 for manual acupuncture; SMD=0.65,95%CI=(0.20,1.10),p=0.03 for electroacupuncture and SMD=0.55,95%CI=(0.13,0.97),p=0.01 for acupressure. However, their differences were insignificant (p=0.38). Therapeutic effect was demonstrated within each cancer-pain subtype, but differences among subgroups were insignificant (p=0.09). LI4, auricular Shenmen, LR3, PC6 and ST36 were 5 most commonly used acupoints.
Conclusion: Acupuncture is effective in reducing cancer-related pain, though no evidence supported the superiority in any mode of therapy or pain type. Acupoints distribution could guide physicians in relieving cancer-pain. |
| first_indexed | 2024-10-01T07:14:30Z |
| format | Final Year Project (FYP) |
| id | ntu-10356/160882 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:14:30Z |
| publishDate | 2022 |
| publisher | Nanyang Technological University |
| record_format | dspace |
| spelling | ntu-10356/1608822023-02-28T18:09:26Z Efficacy of integrating acupuncture to reduce cancer-related pain: a meta-analysis Deng, Grace Zheyun Zhao Yan School of Biological Sciences ZhaoYan@ntu.edu.sg Science::Biological sciences Background: Pain is commonly experienced by cancer patients, compromising quality of life. This study aims to investigate the efficacy of acupuncture and identify the acupoints distribution in alleviating cancer-related pain. Methods: Six established databases were searched from inception through 25 May 2022. Eligible trials were analyzed using Review Manager 5.4.1. Subgroup analysis was conducted to determine whether any mode of acupuncture or cancer-pain had significantly better efficacy than the rest. R-Studio Version 4.1.1 was used to generate relative frequency plot of highly-used acupoints. Results: 21 eligible trials covering 1413 participants were included. Meta-analysis revealed that efficacy of acupuncture analgesia was significantly higher than the control [SMD(Standardized mean difference)=0.85, 95%CI(confidence interval)=(0.58,1.13), p<0.00001]. The four therapies showed significant benefit in reducing cancer-pain, where SMD=1.33,95%CI=(0.13,2.53),p=0.03 for moxibustion; SMD=0.97,95%CI=(0.57,1.38),p<0.00001 for manual acupuncture; SMD=0.65,95%CI=(0.20,1.10),p=0.03 for electroacupuncture and SMD=0.55,95%CI=(0.13,0.97),p=0.01 for acupressure. However, their differences were insignificant (p=0.38). Therapeutic effect was demonstrated within each cancer-pain subtype, but differences among subgroups were insignificant (p=0.09). LI4, auricular Shenmen, LR3, PC6 and ST36 were 5 most commonly used acupoints. Conclusion: Acupuncture is effective in reducing cancer-related pain, though no evidence supported the superiority in any mode of therapy or pain type. Acupoints distribution could guide physicians in relieving cancer-pain. Bachelor of Science in Biomedical Sciences 2022-08-05T04:28:13Z 2022-08-05T04:28:13Z 2022 Final Year Project (FYP) Deng, G. Z. (2022). Efficacy of integrating acupuncture to reduce cancer-related pain: a meta-analysis. Final Year Project (FYP), Nanyang Technological University, Singapore. https://hdl.handle.net/10356/160882 https://hdl.handle.net/10356/160882 en application/pdf Nanyang Technological University |
| spellingShingle | Science::Biological sciences Deng, Grace Zheyun Efficacy of integrating acupuncture to reduce cancer-related pain: a meta-analysis |
| title | Efficacy of integrating acupuncture to reduce cancer-related pain: a meta-analysis |
| title_full | Efficacy of integrating acupuncture to reduce cancer-related pain: a meta-analysis |
| title_fullStr | Efficacy of integrating acupuncture to reduce cancer-related pain: a meta-analysis |
| title_full_unstemmed | Efficacy of integrating acupuncture to reduce cancer-related pain: a meta-analysis |
| title_short | Efficacy of integrating acupuncture to reduce cancer-related pain: a meta-analysis |
| title_sort | efficacy of integrating acupuncture to reduce cancer related pain a meta analysis |
| topic | Science::Biological sciences |
| url | https://hdl.handle.net/10356/160882 |
| work_keys_str_mv | AT denggracezheyun efficacyofintegratingacupuncturetoreducecancerrelatedpainametaanalysis |