The versatility of carbohydrates in antimicrobial applications
The worsening situation of global drug resistance is urgently demanding for novel antimicrobial agents. Considerable efforts have been concentrated on developing new antibacterial therapies with new mode of actions, exerting no selective pressure on bacterial mutation, and minimizing toxicity to hos...
| Main Authors: | , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2022
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| Online Access: | https://hdl.handle.net/10356/161207 |
| _version_ | 1811681355538366464 |
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| author | Xu, Yuan Liu, Xue-Wei |
| author2 | School of Physical and Mathematical Sciences |
| author_facet | School of Physical and Mathematical Sciences Xu, Yuan Liu, Xue-Wei |
| author_sort | Xu, Yuan |
| collection | NTU |
| description | The worsening situation of global drug resistance is urgently demanding for novel antimicrobial agents. Considerable efforts have been concentrated on developing new antibacterial therapies with new mode of actions, exerting no selective pressure on bacterial mutation, and minimizing toxicity to host cells. In this context, active targeting can greatly contribute to selectivity between pathogens and mammalian cells in which carbohydrates, playing important roles in numerous biological processes, can be employed as targeting ligands or “trojan horse.” This short account has discussed the recent results of carbohydrate-based antimicrobial agents developed by our group. Other excellent works by other scientists and possible directions in the future are also discussed. |
| first_indexed | 2024-10-01T03:39:38Z |
| format | Journal Article |
| id | ntu-10356/161207 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T03:39:38Z |
| publishDate | 2022 |
| record_format | dspace |
| spelling | ntu-10356/1612072022-08-19T06:02:35Z The versatility of carbohydrates in antimicrobial applications Xu, Yuan Liu, Xue-Wei School of Physical and Mathematical Sciences Science::Chemistry Antimicrobial Carbohydrates The worsening situation of global drug resistance is urgently demanding for novel antimicrobial agents. Considerable efforts have been concentrated on developing new antibacterial therapies with new mode of actions, exerting no selective pressure on bacterial mutation, and minimizing toxicity to host cells. In this context, active targeting can greatly contribute to selectivity between pathogens and mammalian cells in which carbohydrates, playing important roles in numerous biological processes, can be employed as targeting ligands or “trojan horse.” This short account has discussed the recent results of carbohydrate-based antimicrobial agents developed by our group. Other excellent works by other scientists and possible directions in the future are also discussed. Nanyang Technological University The authors gratefully acknowledge financial support by funding from Nanyang Technological University (RG120/18). 2022-08-19T06:02:34Z 2022-08-19T06:02:34Z 2020 Journal Article Xu, Y. & Liu, X. (2020). The versatility of carbohydrates in antimicrobial applications. Journal of the Chinese Chemical Society, 67(12), 2204-2207. https://dx.doi.org/10.1002/jccs.202000356 0009-4536 https://hdl.handle.net/10356/161207 10.1002/jccs.202000356 2-s2.0-85091430705 12 67 2204 2207 en RG120/18 Journal of the Chinese Chemical Society © 2020 The Chemical Society Located in Taipei & Wiley-VCH GmbH. All rights reserved. |
| spellingShingle | Science::Chemistry Antimicrobial Carbohydrates Xu, Yuan Liu, Xue-Wei The versatility of carbohydrates in antimicrobial applications |
| title | The versatility of carbohydrates in antimicrobial applications |
| title_full | The versatility of carbohydrates in antimicrobial applications |
| title_fullStr | The versatility of carbohydrates in antimicrobial applications |
| title_full_unstemmed | The versatility of carbohydrates in antimicrobial applications |
| title_short | The versatility of carbohydrates in antimicrobial applications |
| title_sort | versatility of carbohydrates in antimicrobial applications |
| topic | Science::Chemistry Antimicrobial Carbohydrates |
| url | https://hdl.handle.net/10356/161207 |
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