Coordination chemistry of ligands: insights into the design of amyloid beta/tau-PET imaging probes and nanoparticles-based therapies for Alzheimer's disease
The diagnosis and therapy of neurodegenerative diseases are highly indispensable. In particular, the definitive clinical diagnosis and therapy of Alzheimer's disease (AD) remains a challenge. Despite the use of amyloid beta (Aβ) positron emission tomography (PET) gold standard [11C]-PiB, other...
| Main Authors: | , , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2022
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| Online Access: | https://hdl.handle.net/10356/161208 |
| _version_ | 1811687852365316096 |
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| author | Selvan, Subramanian Tamil Ravichandar, Roopa Ghosh, Krishna Kanta Mohan, A. Mahalakshmi, Pachaiyappan Gulyás, Balázs Padmanabhan, Parasuraman |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Selvan, Subramanian Tamil Ravichandar, Roopa Ghosh, Krishna Kanta Mohan, A. Mahalakshmi, Pachaiyappan Gulyás, Balázs Padmanabhan, Parasuraman |
| author_sort | Selvan, Subramanian Tamil |
| collection | NTU |
| description | The diagnosis and therapy of neurodegenerative diseases are highly indispensable. In particular, the definitive clinical diagnosis and therapy of Alzheimer's disease (AD) remains a challenge. Despite the use of amyloid beta (Aβ) positron emission tomography (PET) gold standard [11C]-PiB, other approved benzothiazole ([18F]-flutemetamol) and stilbene derivative ([18F]-florbetaben and [18F]-florbetapir) based probes have been extensively studied and advocated as potential early Aβ PET radioligands for AD. Recent years have witnessed a burgeoning research activity in the development of radiotracers for tau neurofibrillary tangles (NFTs) binding using PET imaging, while monitoring the progression of disease. Notably, several tau PET ligands (e.g. [18F]-THK5351, [18F]-MK-6240, and [18F]-AV-1451, [18F]-RO-6958948, [18F]-JNJ-64326067, [18F]-PI-2620) showed high affinity and selective binding to tau pathology. Although early detection and progression of AD have been studied extensively using PET imaging, therapeutic approaches to the disease are scarce. Recently, nanoparticles (NPs) based therapeutic approaches have emerged. Coordination of ligands to the surface of organic NPs (e.g., flavonoids: green tea polyphenol- EGCG, curcumin), and inorganic NPs (e.g. Au, ZnO, CeO2) have been explored to decrease/inhibit the amyloid aggregation and tau hyperphosphorylation. This review focuses on (i) the importance of coordination chemistry of ligands in the design of PET imaging probes with specific binding affinities to Aβ and tau NFTs in AD, and (ii) the role of surface ligands and their coordination to NPs and functional molecules for the rational design of novel anti-AD reagents for therapeutic interventions. |
| first_indexed | 2024-10-01T05:22:54Z |
| format | Journal Article |
| id | ntu-10356/161208 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T05:22:54Z |
| publishDate | 2022 |
| record_format | dspace |
| spelling | ntu-10356/1612082022-08-19T06:21:15Z Coordination chemistry of ligands: insights into the design of amyloid beta/tau-PET imaging probes and nanoparticles-based therapies for Alzheimer's disease Selvan, Subramanian Tamil Ravichandar, Roopa Ghosh, Krishna Kanta Mohan, A. Mahalakshmi, Pachaiyappan Gulyás, Balázs Padmanabhan, Parasuraman Lee Kong Chian School of Medicine (LKCMedicine) Science::Medicine Alzheimer's Disease Coordination Chemistry The diagnosis and therapy of neurodegenerative diseases are highly indispensable. In particular, the definitive clinical diagnosis and therapy of Alzheimer's disease (AD) remains a challenge. Despite the use of amyloid beta (Aβ) positron emission tomography (PET) gold standard [11C]-PiB, other approved benzothiazole ([18F]-flutemetamol) and stilbene derivative ([18F]-florbetaben and [18F]-florbetapir) based probes have been extensively studied and advocated as potential early Aβ PET radioligands for AD. Recent years have witnessed a burgeoning research activity in the development of radiotracers for tau neurofibrillary tangles (NFTs) binding using PET imaging, while monitoring the progression of disease. Notably, several tau PET ligands (e.g. [18F]-THK5351, [18F]-MK-6240, and [18F]-AV-1451, [18F]-RO-6958948, [18F]-JNJ-64326067, [18F]-PI-2620) showed high affinity and selective binding to tau pathology. Although early detection and progression of AD have been studied extensively using PET imaging, therapeutic approaches to the disease are scarce. Recently, nanoparticles (NPs) based therapeutic approaches have emerged. Coordination of ligands to the surface of organic NPs (e.g., flavonoids: green tea polyphenol- EGCG, curcumin), and inorganic NPs (e.g. Au, ZnO, CeO2) have been explored to decrease/inhibit the amyloid aggregation and tau hyperphosphorylation. This review focuses on (i) the importance of coordination chemistry of ligands in the design of PET imaging probes with specific binding affinities to Aβ and tau NFTs in AD, and (ii) the role of surface ligands and their coordination to NPs and functional molecules for the rational design of novel anti-AD reagents for therapeutic interventions. Nanyang Technological University S.T.S., B.G., P.P. thank the support from Lee Kong Chian School of Medicine, Imaging Probe Development Platform, and Cognitive Neuro Imaging Centre (CONIC) at Nanyang Technological University (NTU) Singapore. 2022-08-19T06:21:15Z 2022-08-19T06:21:15Z 2021 Journal Article Selvan, S. T., Ravichandar, R., Ghosh, K. K., Mohan, A., Mahalakshmi, P., Gulyás, B. & Padmanabhan, P. (2021). Coordination chemistry of ligands: insights into the design of amyloid beta/tau-PET imaging probes and nanoparticles-based therapies for Alzheimer's disease. Coordination Chemistry Reviews, 430, 213659-. https://dx.doi.org/10.1016/j.ccr.2020.213659 0010-8545 https://hdl.handle.net/10356/161208 10.1016/j.ccr.2020.213659 2-s2.0-85096476818 430 213659 en Coordination Chemistry Reviews © 2020 Elsevier B.V. All rights reserved. |
| spellingShingle | Science::Medicine Alzheimer's Disease Coordination Chemistry Selvan, Subramanian Tamil Ravichandar, Roopa Ghosh, Krishna Kanta Mohan, A. Mahalakshmi, Pachaiyappan Gulyás, Balázs Padmanabhan, Parasuraman Coordination chemistry of ligands: insights into the design of amyloid beta/tau-PET imaging probes and nanoparticles-based therapies for Alzheimer's disease |
| title | Coordination chemistry of ligands: insights into the design of amyloid beta/tau-PET imaging probes and nanoparticles-based therapies for Alzheimer's disease |
| title_full | Coordination chemistry of ligands: insights into the design of amyloid beta/tau-PET imaging probes and nanoparticles-based therapies for Alzheimer's disease |
| title_fullStr | Coordination chemistry of ligands: insights into the design of amyloid beta/tau-PET imaging probes and nanoparticles-based therapies for Alzheimer's disease |
| title_full_unstemmed | Coordination chemistry of ligands: insights into the design of amyloid beta/tau-PET imaging probes and nanoparticles-based therapies for Alzheimer's disease |
| title_short | Coordination chemistry of ligands: insights into the design of amyloid beta/tau-PET imaging probes and nanoparticles-based therapies for Alzheimer's disease |
| title_sort | coordination chemistry of ligands insights into the design of amyloid beta tau pet imaging probes and nanoparticles based therapies for alzheimer s disease |
| topic | Science::Medicine Alzheimer's Disease Coordination Chemistry |
| url | https://hdl.handle.net/10356/161208 |
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