Hexatic phase in a model of active biological tissues
In many biological processes, such as wound healing, cell tissues undergo an epithelial-to-mesenchymal transition, which is a transition from a more rigid to a more fluid state. Here, we investigate the solid/fluid transition of cell tissues within the framework of the self-propelled Voronoi model,...
| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2022
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/161246 |
| _version_ | 1826114228723908608 |
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| author | Pasupalak, Anshuman Li, Yan-Wei Ni, Ran Ciamarra, Massimo Pica |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Pasupalak, Anshuman Li, Yan-Wei Ni, Ran Ciamarra, Massimo Pica |
| author_sort | Pasupalak, Anshuman |
| collection | NTU |
| description | In many biological processes, such as wound healing, cell tissues undergo an epithelial-to-mesenchymal transition, which is a transition from a more rigid to a more fluid state. Here, we investigate the solid/fluid transition of cell tissues within the framework of the self-propelled Voronoi model, which accounts for the deformability of the cells, for their many-body interactions, and for their polarized motility. The transition is controlled by two parameters, respectively accounting for the strength of the self-propelling force of the cells, and for the mechanical rigidity of the cells. We find the melting transition to occur via a continuous solid-hexatic transition followed by a continuous hexatic-liquid transition, as in the Kosterlitz, Thouless, Halperin, Nelson, and Young scenario. This finding indicates that the hexatic phase may have an unexpected biological relevance. |
| first_indexed | 2024-10-01T03:36:03Z |
| format | Journal Article |
| id | ntu-10356/161246 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T03:36:03Z |
| publishDate | 2022 |
| record_format | dspace |
| spelling | ntu-10356/1612462022-08-22T06:36:08Z Hexatic phase in a model of active biological tissues Pasupalak, Anshuman Li, Yan-Wei Ni, Ran Ciamarra, Massimo Pica School of Chemical and Biomedical Engineering School of Physical and Mathematical Sciences Engineering::Bioengineering Biological Tissues Liquid Transition In many biological processes, such as wound healing, cell tissues undergo an epithelial-to-mesenchymal transition, which is a transition from a more rigid to a more fluid state. Here, we investigate the solid/fluid transition of cell tissues within the framework of the self-propelled Voronoi model, which accounts for the deformability of the cells, for their many-body interactions, and for their polarized motility. The transition is controlled by two parameters, respectively accounting for the strength of the self-propelling force of the cells, and for the mechanical rigidity of the cells. We find the melting transition to occur via a continuous solid-hexatic transition followed by a continuous hexatic-liquid transition, as in the Kosterlitz, Thouless, Halperin, Nelson, and Young scenario. This finding indicates that the hexatic phase may have an unexpected biological relevance. Ministry of Education (MOE) We thank the Singapore Ministry of Education through the Academic Research Fund MOE2017-T2-1-066 (S) (Tier 2) and 2019-T1-001-032 (Tier 1). 2022-08-22T06:36:08Z 2022-08-22T06:36:08Z 2020 Journal Article Pasupalak, A., Li, Y., Ni, R. & Ciamarra, M. P. (2020). Hexatic phase in a model of active biological tissues. Soft Matter, 16(16), 3914-3920. https://dx.doi.org/10.1039/d0sm00109k 1744-683X https://hdl.handle.net/10356/161246 10.1039/d0sm00109k 32270837 2-s2.0-85084181088 16 16 3914 3920 en MOE2017-T2-1-066 (S) 2019-T1-001-032 Soft Matter © 2020 The Authors. All rights reserved. |
| spellingShingle | Engineering::Bioengineering Biological Tissues Liquid Transition Pasupalak, Anshuman Li, Yan-Wei Ni, Ran Ciamarra, Massimo Pica Hexatic phase in a model of active biological tissues |
| title | Hexatic phase in a model of active biological tissues |
| title_full | Hexatic phase in a model of active biological tissues |
| title_fullStr | Hexatic phase in a model of active biological tissues |
| title_full_unstemmed | Hexatic phase in a model of active biological tissues |
| title_short | Hexatic phase in a model of active biological tissues |
| title_sort | hexatic phase in a model of active biological tissues |
| topic | Engineering::Bioengineering Biological Tissues Liquid Transition |
| url | https://hdl.handle.net/10356/161246 |
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