Understanding choline bioavailability and utilization: first step toward personalizing choline nutrition
Choline is an essential macronutrient involved in neurotransmitter synthesis, cell-membrane signaling, lipid transport, and methyl-group metabolism. Nevertheless, the vast majority are not meeting the recommended intake requirement. Choline deficiency is linked to nonalcoholic fatty liver disease, s...
| Main Authors: | , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2022
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| Online Access: | https://hdl.handle.net/10356/161363 |
| _version_ | 1811680217674022912 |
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| author | Goh, Ying Qi Cheam, Guoxiang Wang, Yulan |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Goh, Ying Qi Cheam, Guoxiang Wang, Yulan |
| author_sort | Goh, Ying Qi |
| collection | NTU |
| description | Choline is an essential macronutrient involved in neurotransmitter synthesis, cell-membrane signaling, lipid transport, and methyl-group metabolism. Nevertheless, the vast majority are not meeting the recommended intake requirement. Choline deficiency is linked to nonalcoholic fatty liver disease, skeletal muscle atrophy, and neurodegenerative diseases. The conversion of dietary choline to trimethylamine by gut microbiota is known for its association with atherosclerosis and may contribute to choline deficiency. Choline-utilizing bacteria constitutes less than 1% of the gut community and is modulated by lifestyle interventions such as dietary patterns, antibiotics, and probiotics. In addition, choline utilization is also affected by genetic factors, further complicating the impact of choline on health. This review overviews the complex interplay between dietary intakes of choline, gut microbiota and genetic factors, and the subsequent impact on health. Understanding of gut microbiota metabolism of choline substrates and interindividual variability is warranted in the development of personalized choline nutrition. |
| first_indexed | 2024-10-01T03:21:33Z |
| format | Journal Article |
| id | ntu-10356/161363 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T03:21:33Z |
| publishDate | 2022 |
| record_format | dspace |
| spelling | ntu-10356/1613632022-08-29T07:53:26Z Understanding choline bioavailability and utilization: first step toward personalizing choline nutrition Goh, Ying Qi Cheam, Guoxiang Wang, Yulan Lee Kong Chian School of Medicine (LKCMedicine) School of Biological Sciences Singapore Phenome Centre Science::Biological sciences Gut Microbiota Trimethylamine Choline is an essential macronutrient involved in neurotransmitter synthesis, cell-membrane signaling, lipid transport, and methyl-group metabolism. Nevertheless, the vast majority are not meeting the recommended intake requirement. Choline deficiency is linked to nonalcoholic fatty liver disease, skeletal muscle atrophy, and neurodegenerative diseases. The conversion of dietary choline to trimethylamine by gut microbiota is known for its association with atherosclerosis and may contribute to choline deficiency. Choline-utilizing bacteria constitutes less than 1% of the gut community and is modulated by lifestyle interventions such as dietary patterns, antibiotics, and probiotics. In addition, choline utilization is also affected by genetic factors, further complicating the impact of choline on health. This review overviews the complex interplay between dietary intakes of choline, gut microbiota and genetic factors, and the subsequent impact on health. Understanding of gut microbiota metabolism of choline substrates and interindividual variability is warranted in the development of personalized choline nutrition. Startup funding from Lee Kong Chian School of Medicine is acknowledged. 2022-08-29T07:41:24Z 2022-08-29T07:41:24Z 2021 Journal Article Goh, Y. Q., Cheam, G. & Wang, Y. (2021). Understanding choline bioavailability and utilization: first step toward personalizing choline nutrition. Journal of Agricultural and Food Chemistry, 69(37), 10774-10789. https://dx.doi.org/10.1021/acs.jafc.1c03077 0021-8561 https://hdl.handle.net/10356/161363 10.1021/acs.jafc.1c03077 34392687 2-s2.0-85114095312 37 69 10774 10789 en Journal of Agricultural and Food Chemistry © 2021 American Chemical Society. All rights reserved. |
| spellingShingle | Science::Biological sciences Gut Microbiota Trimethylamine Goh, Ying Qi Cheam, Guoxiang Wang, Yulan Understanding choline bioavailability and utilization: first step toward personalizing choline nutrition |
| title | Understanding choline bioavailability and utilization: first step toward personalizing choline nutrition |
| title_full | Understanding choline bioavailability and utilization: first step toward personalizing choline nutrition |
| title_fullStr | Understanding choline bioavailability and utilization: first step toward personalizing choline nutrition |
| title_full_unstemmed | Understanding choline bioavailability and utilization: first step toward personalizing choline nutrition |
| title_short | Understanding choline bioavailability and utilization: first step toward personalizing choline nutrition |
| title_sort | understanding choline bioavailability and utilization first step toward personalizing choline nutrition |
| topic | Science::Biological sciences Gut Microbiota Trimethylamine |
| url | https://hdl.handle.net/10356/161363 |
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