A comparative study of biomechanical and geometrical attributes of abdominal aortic aneurysms in the Asian and Caucasian populations
In this work, we provide a quantitative assessment of the biomechanical and geometric features that characterize abdominal aortic aneurysm (AAA) models generated from 19 Asian and 19 Caucasian diameter-matched AAA patients. 3D patient-specific finite element models were generated and used to compute...
| Main Authors: | , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
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2022
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| Online Access: | https://hdl.handle.net/10356/161387 |
| _version_ | 1826130199412998144 |
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| author | Canchi, Tejas Patnaik, Sourav S. Nguyen, Hong N. Ng, Eddie Yin Kwee Narayanan, Sriram Muluk, Satish C. De Oliveira, Victor Finol, Ender A. |
| author2 | School of Mechanical and Aerospace Engineering |
| author_facet | School of Mechanical and Aerospace Engineering Canchi, Tejas Patnaik, Sourav S. Nguyen, Hong N. Ng, Eddie Yin Kwee Narayanan, Sriram Muluk, Satish C. De Oliveira, Victor Finol, Ender A. |
| author_sort | Canchi, Tejas |
| collection | NTU |
| description | In this work, we provide a quantitative assessment of the biomechanical and geometric features that characterize abdominal aortic aneurysm (AAA) models generated from 19 Asian and 19 Caucasian diameter-matched AAA patients. 3D patient-specific finite element models were generated and used to compute peak wall stress (PWS), 99th percentile wall stress (99th WS), and spatially averaged wall stress (AWS) for each AAA. In addition, 51 global geometric indices were calculated, which quantify the wall thickness, shape, and curvature of each AAA. The indices were correlated with 99th WS (the only biomechanical metric that exhibited significant association with geometric indices) using Spearman's correlation and subsequently with multivariate linear regression using backward elimination. For the Asian AAA group, 99th WS was highly correlated (R2 = 0.77) with three geometric indices, namely tortuosity, intraluminal thrombus volume, and area-averaged Gaussian curvature. Similarly, 99th WS in the Caucasian AAA group was highly correlated (R2 = 0.87) with six geometric indices, namely maximum AAA diameter, distal neck diameter, diameter-height ratio, minimum wall thickness variance, mode of the wall thickness variance, and area-averaged Gaussian curvature. Significant differences were found between the two groups for ten geometric indices; however, no differences were found for any of their respective biomechanical attributes. Assuming maximum AAA diameter as the most predictive metric for wall stress was found to be imprecise: 24% and 28% accuracy for the Asian and Caucasian groups, respectively. This investigation reveals that geometric indices other than maximum AAA diameter can serve as predictors of wall stress, and potentially for assessment of aneurysm rupture risk, in the Asian and Caucasian AAA populations. |
| first_indexed | 2024-10-01T07:52:35Z |
| format | Journal Article |
| id | ntu-10356/161387 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:52:35Z |
| publishDate | 2022 |
| record_format | dspace |
| spelling | ntu-10356/1613872022-08-30T07:00:33Z A comparative study of biomechanical and geometrical attributes of abdominal aortic aneurysms in the Asian and Caucasian populations Canchi, Tejas Patnaik, Sourav S. Nguyen, Hong N. Ng, Eddie Yin Kwee Narayanan, Sriram Muluk, Satish C. De Oliveira, Victor Finol, Ender A. School of Mechanical and Aerospace Engineering Engineering::Mechanical engineering Geometric Modeling Abdominal Aortic Aneurysm In this work, we provide a quantitative assessment of the biomechanical and geometric features that characterize abdominal aortic aneurysm (AAA) models generated from 19 Asian and 19 Caucasian diameter-matched AAA patients. 3D patient-specific finite element models were generated and used to compute peak wall stress (PWS), 99th percentile wall stress (99th WS), and spatially averaged wall stress (AWS) for each AAA. In addition, 51 global geometric indices were calculated, which quantify the wall thickness, shape, and curvature of each AAA. The indices were correlated with 99th WS (the only biomechanical metric that exhibited significant association with geometric indices) using Spearman's correlation and subsequently with multivariate linear regression using backward elimination. For the Asian AAA group, 99th WS was highly correlated (R2 = 0.77) with three geometric indices, namely tortuosity, intraluminal thrombus volume, and area-averaged Gaussian curvature. Similarly, 99th WS in the Caucasian AAA group was highly correlated (R2 = 0.87) with six geometric indices, namely maximum AAA diameter, distal neck diameter, diameter-height ratio, minimum wall thickness variance, mode of the wall thickness variance, and area-averaged Gaussian curvature. Significant differences were found between the two groups for ten geometric indices; however, no differences were found for any of their respective biomechanical attributes. Assuming maximum AAA diameter as the most predictive metric for wall stress was found to be imprecise: 24% and 28% accuracy for the Asian and Caucasian groups, respectively. This investigation reveals that geometric indices other than maximum AAA diameter can serve as predictors of wall stress, and potentially for assessment of aneurysm rupture risk, in the Asian and Caucasian AAA populations. Nanyang Technological University This work was funded by a Research Student Scholarship from the Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore to Tejas Canchi, and a U.S. National Institutes of Health award (R01HL121293) to Ender A. Finol. 2022-08-30T07:00:33Z 2022-08-30T07:00:33Z 2020 Journal Article Canchi, T., Patnaik, S. S., Nguyen, H. N., Ng, E. Y. K., Narayanan, S., Muluk, S. C., De Oliveira, V. & Finol, E. A. (2020). A comparative study of biomechanical and geometrical attributes of abdominal aortic aneurysms in the Asian and Caucasian populations. Journal of Biomechanical Engineering, 142(6), 061003-. https://dx.doi.org/10.1115/1.4045268 0148-0731 https://hdl.handle.net/10356/161387 10.1115/1.4045268 31633169 2-s2.0-85089014842 6 142 061003 en Journal of Biomechanical Engineering © 2020 ASME. All rights reserved. |
| spellingShingle | Engineering::Mechanical engineering Geometric Modeling Abdominal Aortic Aneurysm Canchi, Tejas Patnaik, Sourav S. Nguyen, Hong N. Ng, Eddie Yin Kwee Narayanan, Sriram Muluk, Satish C. De Oliveira, Victor Finol, Ender A. A comparative study of biomechanical and geometrical attributes of abdominal aortic aneurysms in the Asian and Caucasian populations |
| title | A comparative study of biomechanical and geometrical attributes of abdominal aortic aneurysms in the Asian and Caucasian populations |
| title_full | A comparative study of biomechanical and geometrical attributes of abdominal aortic aneurysms in the Asian and Caucasian populations |
| title_fullStr | A comparative study of biomechanical and geometrical attributes of abdominal aortic aneurysms in the Asian and Caucasian populations |
| title_full_unstemmed | A comparative study of biomechanical and geometrical attributes of abdominal aortic aneurysms in the Asian and Caucasian populations |
| title_short | A comparative study of biomechanical and geometrical attributes of abdominal aortic aneurysms in the Asian and Caucasian populations |
| title_sort | comparative study of biomechanical and geometrical attributes of abdominal aortic aneurysms in the asian and caucasian populations |
| topic | Engineering::Mechanical engineering Geometric Modeling Abdominal Aortic Aneurysm |
| url | https://hdl.handle.net/10356/161387 |
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