Topologically organized networks in the claustrum reflect functional modularization
Using genetic strategies and viral-based directional tracers, we investigated the topological location and output networks of claustrum (CLA) neuron populations projecting to either the retrosplenial cortex, primary motor cortex, or basolateral amygdala. We found that all three CLA neuron population...
| Main Authors: | , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2022
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| Online Access: | https://hdl.handle.net/10356/161415 |
| _version_ | 1811694465095565312 |
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| author | Ham, Gao Xiang Augustine, George James |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Ham, Gao Xiang Augustine, George James |
| author_sort | Ham, Gao Xiang |
| collection | NTU |
| description | Using genetic strategies and viral-based directional tracers, we investigated the topological location and output networks of claustrum (CLA) neuron populations projecting to either the retrosplenial cortex, primary motor cortex, or basolateral amygdala. We found that all three CLA neuron populations clearly reside in distinct topological locations within the CLA complex and project broadly to multiple downstream targets. Each neuron population projects to different targets, suggesting that each CLA subzone coordinates a unique set of brain-wide functions. Our findings establish that the claustrum complex encompasses at least three minimally overlapping networks that are compartmentalized into different topological subzones. Such modularity is likely to be important for CLA function. |
| first_indexed | 2024-10-01T07:08:00Z |
| format | Journal Article |
| id | ntu-10356/161415 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:08:00Z |
| publishDate | 2022 |
| record_format | dspace |
| spelling | ntu-10356/1614152023-03-05T16:55:21Z Topologically organized networks in the claustrum reflect functional modularization Ham, Gao Xiang Augustine, George James Lee Kong Chian School of Medicine (LKCMedicine) Science::Medicine Claustrum Networks Using genetic strategies and viral-based directional tracers, we investigated the topological location and output networks of claustrum (CLA) neuron populations projecting to either the retrosplenial cortex, primary motor cortex, or basolateral amygdala. We found that all three CLA neuron populations clearly reside in distinct topological locations within the CLA complex and project broadly to multiple downstream targets. Each neuron population projects to different targets, suggesting that each CLA subzone coordinates a unique set of brain-wide functions. Our findings establish that the claustrum complex encompasses at least three minimally overlapping networks that are compartmentalized into different topological subzones. Such modularity is likely to be important for CLA function. Ministry of Education (MOE) Published version This work was supported by grant MOE2017-T3-1-002 from the Singapore Ministry of Education. 2022-08-31T04:25:24Z 2022-08-31T04:25:24Z 2022 Journal Article Ham, G. X. & Augustine, G. J. (2022). Topologically organized networks in the claustrum reflect functional modularization. Frontiers in Neuroanatomy, 16, 901807-. https://dx.doi.org/10.3389/fnana.2022.901807 1662-5129 https://hdl.handle.net/10356/161415 10.3389/fnana.2022.901807 35815332 2-s2.0-85133849940 16 901807 en MOE2017-T3-1-002 Frontiers in Neuroanatomy 10.21979/N9/FCPGSA © 2022 Ham and Augustine. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. application/pdf |
| spellingShingle | Science::Medicine Claustrum Networks Ham, Gao Xiang Augustine, George James Topologically organized networks in the claustrum reflect functional modularization |
| title | Topologically organized networks in the claustrum reflect functional modularization |
| title_full | Topologically organized networks in the claustrum reflect functional modularization |
| title_fullStr | Topologically organized networks in the claustrum reflect functional modularization |
| title_full_unstemmed | Topologically organized networks in the claustrum reflect functional modularization |
| title_short | Topologically organized networks in the claustrum reflect functional modularization |
| title_sort | topologically organized networks in the claustrum reflect functional modularization |
| topic | Science::Medicine Claustrum Networks |
| url | https://hdl.handle.net/10356/161415 |
| work_keys_str_mv | AT hamgaoxiang topologicallyorganizednetworksintheclaustrumreflectfunctionalmodularization AT augustinegeorgejames topologicallyorganizednetworksintheclaustrumreflectfunctionalmodularization |