Molecular basis of accessible plasma membrane cholesterol recognition by the GRAM domain of GRAMD1b

Molecular basis of accessible plasma membrane cholesterol recognition by the GRAM domain of GRAMD1b

Cholesterol is essential for cell physiology. Transport of the "accessible" pool of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) by ER-localized GRAMD1 proteins (GRAMD1a/1b/1c) contributes to cholesterol homeostasis. However, how cells detect accessible chole...

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Bibliographic Details
Main Authors: Ercan, Bilge, Naito, Tomoki, Koh, Dylan Hong Zheng, Dharmawan, Dennis, Saheki, Yasunori
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Journal Article
Language:English
Published: 2022
Subjects:
Science::Medicine
Cholesterol
Lipid Sensor
Online Access:https://hdl.handle.net/10356/161493

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