Combining vascular and nerve fiber layer thickness measurements to model glaucomatous focal visual field loss
We compare the focal structure-function correlation of structural measurements of peripapillary retinal nerve fiber layer thickness (RNFL-T) using optical coherence tomography (OCT), capillary density (CD) measurements using OCT-angiography (OCT-A), or a combination of both, with visual field deviat...
| Main Authors: | , , , , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
| Published: |
2022
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/161832 |
| _version_ | 1826119626448175104 |
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| author | Kallab, Martin Hommer, Nikolaus Schlatter, Andreas Chua, Jacqueline Tan, Bingyao Schmidl, Doreen Hirn, Cornelia Findl, Oliver Schmetterer, Leopold Garhöfer, Gerhard Wong, Damon |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Kallab, Martin Hommer, Nikolaus Schlatter, Andreas Chua, Jacqueline Tan, Bingyao Schmidl, Doreen Hirn, Cornelia Findl, Oliver Schmetterer, Leopold Garhöfer, Gerhard Wong, Damon |
| author_sort | Kallab, Martin |
| collection | NTU |
| description | We compare the focal structure-function correlation of structural measurements of peripapillary retinal nerve fiber layer thickness (RNFL-T) using optical coherence tomography (OCT), capillary density (CD) measurements using OCT-angiography (OCT-A), or a combination of both, with visual field deviation (VFD) in early to advanced glaucoma. Primary open angle glaucoma patients (n = 46, mean ± SD age: 67 ± 10 years; VF mean deviation: -10.41 ± 6.76 dB) were included in this cross-sectional study. We performed 30-2 standard automated perimetry OCT (3.5-mm diameter ring scan) and 15°×15° OCT-A (superficial vascular complex slab). Based on a nerve fiber trajectory model, each VF test spot was assigned to an OCT-A wedge and an OCT ring-sector. Two univariate linear models (Mv and Mt ) using either CD-based vascular (Mv ) or RNFL-T-based thickness information (Mt ) and one multivariate model using both (Mv:t ) were compared in their associations with measured focal VFD, which were higher for the multivariate model Mv:t (mean ± SD correlation coefficient: 0.710 ± 0.086) than for either nested model (0.627 ± 0.078 for Mv and 0.578 ± 0.095 for Mt ). Using a focal visual field approach, the combination of RNFL-T and CD showed better structure-function correlations than thickness or vascular information only. |
| first_indexed | 2024-10-01T05:03:30Z |
| format | Journal Article |
| id | ntu-10356/161832 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T05:03:30Z |
| publishDate | 2022 |
| record_format | dspace |
| spelling | ntu-10356/1618322023-12-29T06:48:39Z Combining vascular and nerve fiber layer thickness measurements to model glaucomatous focal visual field loss Kallab, Martin Hommer, Nikolaus Schlatter, Andreas Chua, Jacqueline Tan, Bingyao Schmidl, Doreen Hirn, Cornelia Findl, Oliver Schmetterer, Leopold Garhöfer, Gerhard Wong, Damon School of Chemical and Biomedical Engineering Singapore National Eye Centre Duke-NUS Medical School SERI-NTU Advanced Ocular Engineering (STANCE) Engineering::Bioengineering Glaucoma Retinal Nerve Fiber Layer We compare the focal structure-function correlation of structural measurements of peripapillary retinal nerve fiber layer thickness (RNFL-T) using optical coherence tomography (OCT), capillary density (CD) measurements using OCT-angiography (OCT-A), or a combination of both, with visual field deviation (VFD) in early to advanced glaucoma. Primary open angle glaucoma patients (n = 46, mean ± SD age: 67 ± 10 years; VF mean deviation: -10.41 ± 6.76 dB) were included in this cross-sectional study. We performed 30-2 standard automated perimetry OCT (3.5-mm diameter ring scan) and 15°×15° OCT-A (superficial vascular complex slab). Based on a nerve fiber trajectory model, each VF test spot was assigned to an OCT-A wedge and an OCT ring-sector. Two univariate linear models (Mv and Mt ) using either CD-based vascular (Mv ) or RNFL-T-based thickness information (Mt ) and one multivariate model using both (Mv:t ) were compared in their associations with measured focal VFD, which were higher for the multivariate model Mv:t (mean ± SD correlation coefficient: 0.710 ± 0.086) than for either nested model (0.627 ± 0.078 for Mv and 0.578 ± 0.095 for Mt ). Using a focal visual field approach, the combination of RNFL-T and CD showed better structure-function correlations than thickness or vascular information only. Agency for Science, Technology and Research (A*STAR) Nanyang Technological University National Research Foundation (NRF) Published version Financial support from the Austrian Science Fund FWF Project KLI 854, the National Medical Research Council (CG/C010A/2017;OFIRG/0048/2017; OFLCG/004c/2018; and TA/MOH-000249-00/2018), the National Research Foundation Singapore, A∗STAR (A20H4b0141),the Singapore Eye Research Institute & Nanyang Technological University (SERI-NTU Advanced Ocular Engineering (STANCE) Program),the Duke-NUS Medical School (Duke-NUS-KP(Coll)/2018/0009A), and the SERI-Lee Foundation (LF1019-1) Singapore is gratefully acknowledged. 2022-09-21T04:23:33Z 2022-09-21T04:23:33Z 2022 Journal Article Kallab, M., Hommer, N., Schlatter, A., Chua, J., Tan, B., Schmidl, D., Hirn, C., Findl, O., Schmetterer, L., Garhöfer, G. & Wong, D. (2022). Combining vascular and nerve fiber layer thickness measurements to model glaucomatous focal visual field loss. Annals of the New York Academy of Sciences, 1511(1), 133-141. https://dx.doi.org/10.1111/nyas.14732 0077-8923 https://hdl.handle.net/10356/161832 10.1111/nyas.14732 35029314 2-s2.0-85130508775 1 1511 133 141 en TA/MOH-000249-00/2018 A20H4b0141 Duke-NUS-KP(Coll)/2018/0009A LF1019-1 Annals of the New York Academy of Sciences © 2022 The Authors. Annals of the New York Academy of Sciences published by Wiley Periodicals LLC on behalf of New York Academy of Sciences. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. application/pdf |
| spellingShingle | Engineering::Bioengineering Glaucoma Retinal Nerve Fiber Layer Kallab, Martin Hommer, Nikolaus Schlatter, Andreas Chua, Jacqueline Tan, Bingyao Schmidl, Doreen Hirn, Cornelia Findl, Oliver Schmetterer, Leopold Garhöfer, Gerhard Wong, Damon Combining vascular and nerve fiber layer thickness measurements to model glaucomatous focal visual field loss |
| title | Combining vascular and nerve fiber layer thickness measurements to model glaucomatous focal visual field loss |
| title_full | Combining vascular and nerve fiber layer thickness measurements to model glaucomatous focal visual field loss |
| title_fullStr | Combining vascular and nerve fiber layer thickness measurements to model glaucomatous focal visual field loss |
| title_full_unstemmed | Combining vascular and nerve fiber layer thickness measurements to model glaucomatous focal visual field loss |
| title_short | Combining vascular and nerve fiber layer thickness measurements to model glaucomatous focal visual field loss |
| title_sort | combining vascular and nerve fiber layer thickness measurements to model glaucomatous focal visual field loss |
| topic | Engineering::Bioengineering Glaucoma Retinal Nerve Fiber Layer |
| url | https://hdl.handle.net/10356/161832 |
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