The therapeutic dilemma of idiopathic granulomatous mastitis
INTRODUCTION: Idiopathic granulomatous mastitis (IGM) is a rare, benign, chronic breast condition that can cause repeated abscesses or mass formation in bilateral breasts. The condition can severely impact the quality of life of affected women. This study aims to evaluate effective treatment modalit...
| Main Authors: | , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2022
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| Online Access: | https://hdl.handle.net/10356/161859 |
| _version_ | 1811677975131717632 |
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| author | Tang, Serene Ee Ling Ho, Bernard Chi Shern Chan, Patrick Mun Yew Chen, Juliana Jia Chuan Goh, Mui Heng Tan, Ern Yu |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Tang, Serene Ee Ling Ho, Bernard Chi Shern Chan, Patrick Mun Yew Chen, Juliana Jia Chuan Goh, Mui Heng Tan, Ern Yu |
| author_sort | Tang, Serene Ee Ling |
| collection | NTU |
| description | INTRODUCTION: Idiopathic granulomatous mastitis (IGM) is a rare, benign, chronic breast condition that can cause repeated abscesses or mass formation in bilateral breasts. The condition can severely impact the quality of life of affected women. This study aims to evaluate effective treatment modalities, as well as understand the demographics and clinical presentation of patients with IGM. METHODS: An 11-year retrospective review was performed of patients diagnosed with IGM from 1 January 2008 to 31 December 2018 at a tertiary breast unit. RESULTS: A total of 77 patients were included in the study. The median age at presentation was 36 years old. IGM presented most commonly as a breast lump (98.1%). The median number of flares was 2 (1-12). Of the 77 patients, 68.8% (53) were treated with antibiotics, 50.6% (39) with steroids, and 44.2% (34) underwent surgery, in the course of their IGM treatment. Forty-five (59.2%) of the 76 patients with IGM required a multimodal treatment approach to achieve remission. There was no significant difference in the number of flares no matter the initial treatment (P=0.411), or subsequent treatment modality (P=0.343). Smokers had 10 times greater odds of having a "high flare" of IGM compared to those who did not smoke (P=0.031, odds ratio 10.444, 95% confidence interval 1.092-99.859). CONCLUSION: IGM is a clinical diagnosis. It is a rare, relapsing breast inflammatory condition that affects young females with no superior treatment modality. Smoking is associated with higher number of flares of IGM and should be discouraged in IGM patients. |
| first_indexed | 2024-10-01T02:45:54Z |
| format | Journal Article |
| id | ntu-10356/161859 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T02:45:54Z |
| publishDate | 2022 |
| record_format | dspace |
| spelling | ntu-10356/1618592023-03-05T16:50:53Z The therapeutic dilemma of idiopathic granulomatous mastitis Tang, Serene Ee Ling Ho, Bernard Chi Shern Chan, Patrick Mun Yew Chen, Juliana Jia Chuan Goh, Mui Heng Tan, Ern Yu Lee Kong Chian School of Medicine (LKCMedicine) Science::Medicine Breast Inflammation Chronic Mastitis INTRODUCTION: Idiopathic granulomatous mastitis (IGM) is a rare, benign, chronic breast condition that can cause repeated abscesses or mass formation in bilateral breasts. The condition can severely impact the quality of life of affected women. This study aims to evaluate effective treatment modalities, as well as understand the demographics and clinical presentation of patients with IGM. METHODS: An 11-year retrospective review was performed of patients diagnosed with IGM from 1 January 2008 to 31 December 2018 at a tertiary breast unit. RESULTS: A total of 77 patients were included in the study. The median age at presentation was 36 years old. IGM presented most commonly as a breast lump (98.1%). The median number of flares was 2 (1-12). Of the 77 patients, 68.8% (53) were treated with antibiotics, 50.6% (39) with steroids, and 44.2% (34) underwent surgery, in the course of their IGM treatment. Forty-five (59.2%) of the 76 patients with IGM required a multimodal treatment approach to achieve remission. There was no significant difference in the number of flares no matter the initial treatment (P=0.411), or subsequent treatment modality (P=0.343). Smokers had 10 times greater odds of having a "high flare" of IGM compared to those who did not smoke (P=0.031, odds ratio 10.444, 95% confidence interval 1.092-99.859). CONCLUSION: IGM is a clinical diagnosis. It is a rare, relapsing breast inflammatory condition that affects young females with no superior treatment modality. Smoking is associated with higher number of flares of IGM and should be discouraged in IGM patients. Published version 2022-09-22T01:18:51Z 2022-09-22T01:18:51Z 2021 Journal Article Tang, S. E. L., Ho, B. C. S., Chan, P. M. Y., Chen, J. J. C., Goh, M. H. & Tan, E. Y. (2021). The therapeutic dilemma of idiopathic granulomatous mastitis. Annals of the Academy of Medicine, Singapore, 50(8), 598-605. https://dx.doi.org/10.47102/annals-acadmedsg.2020645 0304-4602 https://hdl.handle.net/10356/161859 10.47102/annals-acadmedsg.2020645 50 2-s2.0-85115280815 8 50 598 605 en Annals of the Academy of Medicine, Singapore © 2021 Annals, Academy of Medicine, Singapore. All rights reserved. This paper was published in Annals of the Academy of Medicine, Singapore and is made available with permission of Annals, Academy of Medicine, Singapore. application/pdf |
| spellingShingle | Science::Medicine Breast Inflammation Chronic Mastitis Tang, Serene Ee Ling Ho, Bernard Chi Shern Chan, Patrick Mun Yew Chen, Juliana Jia Chuan Goh, Mui Heng Tan, Ern Yu The therapeutic dilemma of idiopathic granulomatous mastitis |
| title | The therapeutic dilemma of idiopathic granulomatous mastitis |
| title_full | The therapeutic dilemma of idiopathic granulomatous mastitis |
| title_fullStr | The therapeutic dilemma of idiopathic granulomatous mastitis |
| title_full_unstemmed | The therapeutic dilemma of idiopathic granulomatous mastitis |
| title_short | The therapeutic dilemma of idiopathic granulomatous mastitis |
| title_sort | therapeutic dilemma of idiopathic granulomatous mastitis |
| topic | Science::Medicine Breast Inflammation Chronic Mastitis |
| url | https://hdl.handle.net/10356/161859 |
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