Honeys with anti-inflammatory capacity can alter the elderly gut microbiota in an ex vivo gut model
The anti-inflammatory effect of different sourced honeys and the impact on elderly gut microbiota were studied in terms of chemical compositions, anti-inflammatory effect and gut microbiota modulating capacities. All four honeys suppressed the production of pro-inflammatory markers NO, IL-1β and IL-...
| Main Authors: | , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2022
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/161944 |
| _version_ | 1826114608614604800 |
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| author | Wu, Daoyan Chen, Liwei Teh, Jean Sim, Edric Schlundt, Joergen Conway, Patricia Lynne |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Wu, Daoyan Chen, Liwei Teh, Jean Sim, Edric Schlundt, Joergen Conway, Patricia Lynne |
| author_sort | Wu, Daoyan |
| collection | NTU |
| description | The anti-inflammatory effect of different sourced honeys and the impact on elderly gut microbiota were studied in terms of chemical compositions, anti-inflammatory effect and gut microbiota modulating capacities. All four honeys suppressed the production of pro-inflammatory markers NO, IL-1β and IL-6 induced by lipopolysaccharide and promoted the expression of anti-inflammatory cytokines IL-10 in RAW 264.7 cells. Moreover, in the ex vivo batch gut model using elderly fecal microbiota (referred to as microcosm), it was showed that the addition of honeys increased the abundance of beneficial lactobacilli, decreased the abundance of potentially harmful Gram negative enteric bacteria, and exerted a beneficial effect on the production of short chain fatty acids. The concentration of gallic acid in honeys was positively correlated with the expression level of IL-10 and the abundance of lactobacilli. These findings indicate honeys with anti-inflammatory capacity have great potential for regulating the elderly gut microbiota which would lead to health benefits. |
| first_indexed | 2024-10-01T03:41:52Z |
| format | Journal Article |
| id | ntu-10356/161944 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T03:41:52Z |
| publishDate | 2022 |
| record_format | dspace |
| spelling | ntu-10356/1619442022-09-27T03:05:09Z Honeys with anti-inflammatory capacity can alter the elderly gut microbiota in an ex vivo gut model Wu, Daoyan Chen, Liwei Teh, Jean Sim, Edric Schlundt, Joergen Conway, Patricia Lynne School of Chemical and Biomedical Engineering NTU Food Technology Centre Singapore Centre for Environmental Life Sciences and Engineering (SCELSE) Engineering::Bioengineering Phenolic Acid Antioxidants The anti-inflammatory effect of different sourced honeys and the impact on elderly gut microbiota were studied in terms of chemical compositions, anti-inflammatory effect and gut microbiota modulating capacities. All four honeys suppressed the production of pro-inflammatory markers NO, IL-1β and IL-6 induced by lipopolysaccharide and promoted the expression of anti-inflammatory cytokines IL-10 in RAW 264.7 cells. Moreover, in the ex vivo batch gut model using elderly fecal microbiota (referred to as microcosm), it was showed that the addition of honeys increased the abundance of beneficial lactobacilli, decreased the abundance of potentially harmful Gram negative enteric bacteria, and exerted a beneficial effect on the production of short chain fatty acids. The concentration of gallic acid in honeys was positively correlated with the expression level of IL-10 and the abundance of lactobacilli. These findings indicate honeys with anti-inflammatory capacity have great potential for regulating the elderly gut microbiota which would lead to health benefits. Nanyang Technological University We sincerely thank the support from the funding of China Scholarship Council (grant no. 201906240301). 2022-09-27T03:05:08Z 2022-09-27T03:05:08Z 2022 Journal Article Wu, D., Chen, L., Teh, J., Sim, E., Schlundt, J. & Conway, P. L. (2022). Honeys with anti-inflammatory capacity can alter the elderly gut microbiota in an ex vivo gut model. Food Chemistry, 392, 133229-. https://dx.doi.org/10.1016/j.foodchem.2022.133229 0308-8146 https://hdl.handle.net/10356/161944 10.1016/j.foodchem.2022.133229 35679723 2-s2.0-85131461059 392 133229 en Food Chemistry © 2022 Elsevier Ltd. All rights reserved. |
| spellingShingle | Engineering::Bioengineering Phenolic Acid Antioxidants Wu, Daoyan Chen, Liwei Teh, Jean Sim, Edric Schlundt, Joergen Conway, Patricia Lynne Honeys with anti-inflammatory capacity can alter the elderly gut microbiota in an ex vivo gut model |
| title | Honeys with anti-inflammatory capacity can alter the elderly gut microbiota in an ex vivo gut model |
| title_full | Honeys with anti-inflammatory capacity can alter the elderly gut microbiota in an ex vivo gut model |
| title_fullStr | Honeys with anti-inflammatory capacity can alter the elderly gut microbiota in an ex vivo gut model |
| title_full_unstemmed | Honeys with anti-inflammatory capacity can alter the elderly gut microbiota in an ex vivo gut model |
| title_short | Honeys with anti-inflammatory capacity can alter the elderly gut microbiota in an ex vivo gut model |
| title_sort | honeys with anti inflammatory capacity can alter the elderly gut microbiota in an ex vivo gut model |
| topic | Engineering::Bioengineering Phenolic Acid Antioxidants |
| url | https://hdl.handle.net/10356/161944 |
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