Interferon β, an enhancer of the innate immune response against SARS-CoV-2 infection
COVID-19 exhibits a global health threat among the elderly and the population with underlying health conditions. During infection, the host's innate immune response acts as a frontline of defense by releasing cytokines such as type I interferon (IFN α and β) thereby initiating antiviral activit...
| Main Authors: | , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2022
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/162011 |
| _version_ | 1826126317893976064 |
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| author | Kali, Suresh Kumar Dröge, Peter Murugan, Priyatharshini |
| author2 | School of Biological Sciences |
| author_facet | School of Biological Sciences Kali, Suresh Kumar Dröge, Peter Murugan, Priyatharshini |
| author_sort | Kali, Suresh Kumar |
| collection | NTU |
| description | COVID-19 exhibits a global health threat among the elderly and the population with underlying health conditions. During infection, the host's innate immune response acts as a frontline of defense by releasing cytokines such as type I interferon (IFN α and β) thereby initiating antiviral activity. However, this particular interferon response is interrupted by factors such as SARS-CoV-2 non-structural proteins, aging, diabetes, and germ-line errors eventually making the host more susceptible to illness. Therefore, enhancing the host's innate immune response by administering type I IFN could be an effective treatment against COVID-19. Here, we highlight the importance of innate immune response and the role of IFN β monotherapy against COVID-19. |
| first_indexed | 2024-10-01T06:50:43Z |
| format | Journal Article |
| id | ntu-10356/162011 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:50:43Z |
| publishDate | 2022 |
| record_format | dspace |
| spelling | ntu-10356/1620112022-09-29T05:06:39Z Interferon β, an enhancer of the innate immune response against SARS-CoV-2 infection Kali, Suresh Kumar Dröge, Peter Murugan, Priyatharshini School of Biological Sciences Science::Biological sciences Coronavirus Disease 2019 Severe Acute Respiratory Syndrome COVID-19 exhibits a global health threat among the elderly and the population with underlying health conditions. During infection, the host's innate immune response acts as a frontline of defense by releasing cytokines such as type I interferon (IFN α and β) thereby initiating antiviral activity. However, this particular interferon response is interrupted by factors such as SARS-CoV-2 non-structural proteins, aging, diabetes, and germ-line errors eventually making the host more susceptible to illness. Therefore, enhancing the host's innate immune response by administering type I IFN could be an effective treatment against COVID-19. Here, we highlight the importance of innate immune response and the role of IFN β monotherapy against COVID-19. 2022-09-29T05:06:38Z 2022-09-29T05:06:38Z 2021 Journal Article Kali, S. K., Dröge, P. & Murugan, P. (2021). Interferon β, an enhancer of the innate immune response against SARS-CoV-2 infection. Microbial Pathogenesis, 158, 105105-. https://dx.doi.org/10.1016/j.micpath.2021.105105 0882-4010 https://hdl.handle.net/10356/162011 10.1016/j.micpath.2021.105105 34311016 2-s2.0-85111249287 158 105105 en Microbial Pathogenesis © 2021 Elsevier Ltd. All rights reserved. |
| spellingShingle | Science::Biological sciences Coronavirus Disease 2019 Severe Acute Respiratory Syndrome Kali, Suresh Kumar Dröge, Peter Murugan, Priyatharshini Interferon β, an enhancer of the innate immune response against SARS-CoV-2 infection |
| title | Interferon β, an enhancer of the innate immune response against SARS-CoV-2 infection |
| title_full | Interferon β, an enhancer of the innate immune response against SARS-CoV-2 infection |
| title_fullStr | Interferon β, an enhancer of the innate immune response against SARS-CoV-2 infection |
| title_full_unstemmed | Interferon β, an enhancer of the innate immune response against SARS-CoV-2 infection |
| title_short | Interferon β, an enhancer of the innate immune response against SARS-CoV-2 infection |
| title_sort | interferon β an enhancer of the innate immune response against sars cov 2 infection |
| topic | Science::Biological sciences Coronavirus Disease 2019 Severe Acute Respiratory Syndrome |
| url | https://hdl.handle.net/10356/162011 |
| work_keys_str_mv | AT kalisureshkumar interferonbanenhanceroftheinnateimmuneresponseagainstsarscov2infection AT drogepeter interferonbanenhanceroftheinnateimmuneresponseagainstsarscov2infection AT muruganpriyatharshini interferonbanenhanceroftheinnateimmuneresponseagainstsarscov2infection |