Precise chemodynamic therapy of cancer by trifunctional bacterium-based nanozymes
Chemodynamic therapy (CDT) destroys cancer cells by converting H2O2 or O2 into reactive oxygen species (ROS), but its therapeutic efficacy is restricted by the antioxidant capacity of tumor. Previous solutions focused on strengthening the nanodrugs with the ability to increase ROS production or weak...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
| Published: |
2022
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| Online Access: | https://hdl.handle.net/10356/162056 |
| _version_ | 1811677403754266624 |
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| author | Zhang, Weiyun Liu, Jiawei Li, Xuyu Zheng, Yue Chen, Lianfu Wang, Dongdong Foda, Mohamed Frahat Ma, Zhaoyu Zhao, Yanli Han, Heyou |
| author2 | School of Physical and Mathematical Sciences |
| author_facet | School of Physical and Mathematical Sciences Zhang, Weiyun Liu, Jiawei Li, Xuyu Zheng, Yue Chen, Lianfu Wang, Dongdong Foda, Mohamed Frahat Ma, Zhaoyu Zhao, Yanli Han, Heyou |
| author_sort | Zhang, Weiyun |
| collection | NTU |
| description | Chemodynamic therapy (CDT) destroys cancer cells by converting H2O2 or O2 into reactive oxygen species (ROS), but its therapeutic efficacy is restricted by the antioxidant capacity of tumor. Previous solutions focused on strengthening the nanodrugs with the ability to increase ROS production or weaken the antioxidant capacity of cancer cells. Conversely, we here develop a mild nanodrug with negligible side effects. Specifically, the Au@Pt nanozyme decorated on a bacterial surface (Bac-Au@Pt) is reported to achieve precise CDT. Due to the tumor targeting ability of bacteria and catalytic property of Au@Pt nanozyme under acidic conditions, this nanosystem can release ROS to tumor cells effectively. In addition, the interferon gamma released by T cells specifically decreases the intracellular reductants in tumor cells, while having no obvious effect on normal cells. Therefore, a low dose of Bac-Au@Pt achieves a satisfactory therapeutic efficacy to tumor cells and is nontoxic to normal cells even at their acidic components. This nanosystem enables CDT and immunotherapy to mutually benefit and improve by each other, providing a promising strategy to achieve high anticancer efficacy even with a low dose usage. |
| first_indexed | 2024-10-01T02:36:49Z |
| format | Journal Article |
| id | ntu-10356/162056 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T02:36:49Z |
| publishDate | 2022 |
| record_format | dspace |
| spelling | ntu-10356/1620562022-10-03T03:47:11Z Precise chemodynamic therapy of cancer by trifunctional bacterium-based nanozymes Zhang, Weiyun Liu, Jiawei Li, Xuyu Zheng, Yue Chen, Lianfu Wang, Dongdong Foda, Mohamed Frahat Ma, Zhaoyu Zhao, Yanli Han, Heyou School of Physical and Mathematical Sciences Science::Chemistry Ferroptosis Immunotherapy Chemodynamic therapy (CDT) destroys cancer cells by converting H2O2 or O2 into reactive oxygen species (ROS), but its therapeutic efficacy is restricted by the antioxidant capacity of tumor. Previous solutions focused on strengthening the nanodrugs with the ability to increase ROS production or weaken the antioxidant capacity of cancer cells. Conversely, we here develop a mild nanodrug with negligible side effects. Specifically, the Au@Pt nanozyme decorated on a bacterial surface (Bac-Au@Pt) is reported to achieve precise CDT. Due to the tumor targeting ability of bacteria and catalytic property of Au@Pt nanozyme under acidic conditions, this nanosystem can release ROS to tumor cells effectively. In addition, the interferon gamma released by T cells specifically decreases the intracellular reductants in tumor cells, while having no obvious effect on normal cells. Therefore, a low dose of Bac-Au@Pt achieves a satisfactory therapeutic efficacy to tumor cells and is nontoxic to normal cells even at their acidic components. This nanosystem enables CDT and immunotherapy to mutually benefit and improve by each other, providing a promising strategy to achieve high anticancer efficacy even with a low dose usage. National Research Foundation (NRF) This work was financially supported by the National Natural Science Foundation of China (21778020 and 31950410755), the Sci-Tech Innovation Foundation of Huazhong Agricultural University (2662018PY024), the Fundamental Research Funds for the Central Universities (2662015QD026), and the Science and Technology Major Project of Guangxi (Gui Ke AA18118046). This work is also supported by the Singapore National Research Foundation Investigatorship (NRF-NRFI2018-03). 2022-10-03T03:47:11Z 2022-10-03T03:47:11Z 2021 Journal Article Zhang, W., Liu, J., Li, X., Zheng, Y., Chen, L., Wang, D., Foda, M. F., Ma, Z., Zhao, Y. & Han, H. (2021). Precise chemodynamic therapy of cancer by trifunctional bacterium-based nanozymes. ACS Nano, 15(12), 19321-19333. https://dx.doi.org/10.1021/acsnano.1c05605 1936-0851 https://hdl.handle.net/10356/162056 10.1021/acsnano.1c05605 34851608 2-s2.0-85120859183 12 15 19321 19333 en NRF-NRFI2018-03 ACS Nano © 2021 American Chemical Society. All rights reserved. |
| spellingShingle | Science::Chemistry Ferroptosis Immunotherapy Zhang, Weiyun Liu, Jiawei Li, Xuyu Zheng, Yue Chen, Lianfu Wang, Dongdong Foda, Mohamed Frahat Ma, Zhaoyu Zhao, Yanli Han, Heyou Precise chemodynamic therapy of cancer by trifunctional bacterium-based nanozymes |
| title | Precise chemodynamic therapy of cancer by trifunctional bacterium-based nanozymes |
| title_full | Precise chemodynamic therapy of cancer by trifunctional bacterium-based nanozymes |
| title_fullStr | Precise chemodynamic therapy of cancer by trifunctional bacterium-based nanozymes |
| title_full_unstemmed | Precise chemodynamic therapy of cancer by trifunctional bacterium-based nanozymes |
| title_short | Precise chemodynamic therapy of cancer by trifunctional bacterium-based nanozymes |
| title_sort | precise chemodynamic therapy of cancer by trifunctional bacterium based nanozymes |
| topic | Science::Chemistry Ferroptosis Immunotherapy |
| url | https://hdl.handle.net/10356/162056 |
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