Caging cationic polymer brush-coated plasmonic nanostructures for traceable selective antimicrobial activities
Cationic polymers are under intense research to achieve prominent antimicrobial activity. However, the cellular and in vivo toxicity caused by nonspecific electrostatic interaction has become a major challenge for their practical applications. Here, the development of a "caging" strategy b...
| Main Authors: | , , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2022
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| Online Access: | https://hdl.handle.net/10356/162102 |
| _version_ | 1826122886717374464 |
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| author | Ma, Jielin Hou, Shuai Lu, Derong Zhang, Bo Xiong, Qirong Chan-Park, Mary B. Duan, Hongwei |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Ma, Jielin Hou, Shuai Lu, Derong Zhang, Bo Xiong, Qirong Chan-Park, Mary B. Duan, Hongwei |
| author_sort | Ma, Jielin |
| collection | NTU |
| description | Cationic polymers are under intense research to achieve prominent antimicrobial activity. However, the cellular and in vivo toxicity caused by nonspecific electrostatic interaction has become a major challenge for their practical applications. Here, the development of a "caging" strategy based on the use of a block copolymer consisting of a stealth block and an anionic block that undergoes degradation in presence of enzymes secreted by selective bacterial pathogens of interest is reported. The results have shown that antimicrobial cationic polymer brushes-coated gold nanorods (AuNRs) can be caged by the block polymer of poly(ethylene glycol) and anionic, lipase-degradable block of ε-caprolactone and methacrylic acid copolymer to afford neutrally charged surfaces. The caged AuNRs are activated by lipase released by bacteria of interest to endow an excellent bactericidal effect but show minimal binding and toxicity against mammalian cells and nonspecific bacteria that do not produce lipase. In this design, AuNRs play multifunctional roles as the scaffolds for polymer brushes, photothermal transducers, and imaging probes for traceable delivery of the activation and delivery of bactericidal cationic polymer brushes. The caging strategy opens new opportunities for the safe delivery of antimicrobial materials for the treatment of bacterial infections. |
| first_indexed | 2024-10-01T05:55:33Z |
| format | Journal Article |
| id | ntu-10356/162102 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T05:55:33Z |
| publishDate | 2022 |
| record_format | dspace |
| spelling | ntu-10356/1621022022-10-04T05:53:55Z Caging cationic polymer brush-coated plasmonic nanostructures for traceable selective antimicrobial activities Ma, Jielin Hou, Shuai Lu, Derong Zhang, Bo Xiong, Qirong Chan-Park, Mary B. Duan, Hongwei School of Chemical and Biomedical Engineering Engineering::Chemical engineering Anionic Block Copolymers Caged Plasmonic Nanostructures Cationic polymers are under intense research to achieve prominent antimicrobial activity. However, the cellular and in vivo toxicity caused by nonspecific electrostatic interaction has become a major challenge for their practical applications. Here, the development of a "caging" strategy based on the use of a block copolymer consisting of a stealth block and an anionic block that undergoes degradation in presence of enzymes secreted by selective bacterial pathogens of interest is reported. The results have shown that antimicrobial cationic polymer brushes-coated gold nanorods (AuNRs) can be caged by the block polymer of poly(ethylene glycol) and anionic, lipase-degradable block of ε-caprolactone and methacrylic acid copolymer to afford neutrally charged surfaces. The caged AuNRs are activated by lipase released by bacteria of interest to endow an excellent bactericidal effect but show minimal binding and toxicity against mammalian cells and nonspecific bacteria that do not produce lipase. In this design, AuNRs play multifunctional roles as the scaffolds for polymer brushes, photothermal transducers, and imaging probes for traceable delivery of the activation and delivery of bactericidal cationic polymer brushes. The caging strategy opens new opportunities for the safe delivery of antimicrobial materials for the treatment of bacterial infections. Ministry of Education (MOE) The authors acknowledgethe financial support from Singapore Ministry of Education (MOE2018-T3-1-003 and RG49/16). 2022-10-04T05:53:55Z 2022-10-04T05:53:55Z 2022 Journal Article Ma, J., Hou, S., Lu, D., Zhang, B., Xiong, Q., Chan-Park, M. B. & Duan, H. (2022). Caging cationic polymer brush-coated plasmonic nanostructures for traceable selective antimicrobial activities. Macromolecular Rapid Communications, 43(10), 2100812-. https://dx.doi.org/10.1002/marc.202100812 1022-1336 https://hdl.handle.net/10356/162102 10.1002/marc.202100812 35394089 2-s2.0-85128391386 10 43 2100812 en MOE2018-T3-1-003 RG49/16 Macromolecular Rapid Communications © 2022 Wiley-VCH GmbH. All rights reserved. |
| spellingShingle | Engineering::Chemical engineering Anionic Block Copolymers Caged Plasmonic Nanostructures Ma, Jielin Hou, Shuai Lu, Derong Zhang, Bo Xiong, Qirong Chan-Park, Mary B. Duan, Hongwei Caging cationic polymer brush-coated plasmonic nanostructures for traceable selective antimicrobial activities |
| title | Caging cationic polymer brush-coated plasmonic nanostructures for traceable selective antimicrobial activities |
| title_full | Caging cationic polymer brush-coated plasmonic nanostructures for traceable selective antimicrobial activities |
| title_fullStr | Caging cationic polymer brush-coated plasmonic nanostructures for traceable selective antimicrobial activities |
| title_full_unstemmed | Caging cationic polymer brush-coated plasmonic nanostructures for traceable selective antimicrobial activities |
| title_short | Caging cationic polymer brush-coated plasmonic nanostructures for traceable selective antimicrobial activities |
| title_sort | caging cationic polymer brush coated plasmonic nanostructures for traceable selective antimicrobial activities |
| topic | Engineering::Chemical engineering Anionic Block Copolymers Caged Plasmonic Nanostructures |
| url | https://hdl.handle.net/10356/162102 |
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