Biomolecule-interactive flexible light emitting capacitor display
Ultrathin, lightweight, flexible, and conformable interactive displays that transduce external stimuli into human-readable signals are essential for emerging applications, such as wearable electronics, human-machine interfaces, and soft robots. Herein, a biomolecule-interactive flexible light emitti...
| Main Authors: | , , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2022
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/162259 |
| _version_ | 1826129815087874048 |
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| author | Qi, Xiaoying Wu, Ruige Lok, Boon Keng Kerk, Wai Tat Lai, Steve Foo Khuen Fan, Wei Pu, Kanyi |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Qi, Xiaoying Wu, Ruige Lok, Boon Keng Kerk, Wai Tat Lai, Steve Foo Khuen Fan, Wei Pu, Kanyi |
| author_sort | Qi, Xiaoying |
| collection | NTU |
| description | Ultrathin, lightweight, flexible, and conformable interactive displays that transduce external stimuli into human-readable signals are essential for emerging applications, such as wearable electronics, human-machine interfaces, and soft robots. Herein, a biomolecule-interactive flexible light emitting capacitor (LEC) display (BIO-LEC) capable of dynamic and quantitative visualization of biomolecules through naked-eye detectable electroluminescence (EL) emission is reported. BIO-LEC comprises a coplanar LEC light source at the bottom, and a designed microfluidic chip as sampling compartment at the top. The quantitative measurement feature of BIO-LEC is achieved by introducing the top liquid electrode, which possesses a unique long dielectric realization time, in the microfluidic chip. BIO-LEC is novel for the following reasons, 1) simple stimuli response principle based on correlating EL intensity to dielectric properties of the top liquid electrode; 2) simple test conditions whereby no labeling is required in the analyte solution to optically detect biomolecules; 3) effective sampling method through the design of an integrated microfluidic chip for hosting the top liquid electrode, ensuring good reproducibility and preventing contamination; 4) sensitive detection limit for heparin concentrations at clinically relevant levels, and 5) high compliance with industrial manufacturing standards. |
| first_indexed | 2024-10-01T07:46:42Z |
| format | Journal Article |
| id | ntu-10356/162259 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:46:42Z |
| publishDate | 2022 |
| record_format | dspace |
| spelling | ntu-10356/1622592022-10-11T04:51:17Z Biomolecule-interactive flexible light emitting capacitor display Qi, Xiaoying Wu, Ruige Lok, Boon Keng Kerk, Wai Tat Lai, Steve Foo Khuen Fan, Wei Pu, Kanyi School of Chemical and Biomedical Engineering Engineering::Chemical engineering Biomolecules Liquid Electrodes Ultrathin, lightweight, flexible, and conformable interactive displays that transduce external stimuli into human-readable signals are essential for emerging applications, such as wearable electronics, human-machine interfaces, and soft robots. Herein, a biomolecule-interactive flexible light emitting capacitor (LEC) display (BIO-LEC) capable of dynamic and quantitative visualization of biomolecules through naked-eye detectable electroluminescence (EL) emission is reported. BIO-LEC comprises a coplanar LEC light source at the bottom, and a designed microfluidic chip as sampling compartment at the top. The quantitative measurement feature of BIO-LEC is achieved by introducing the top liquid electrode, which possesses a unique long dielectric realization time, in the microfluidic chip. BIO-LEC is novel for the following reasons, 1) simple stimuli response principle based on correlating EL intensity to dielectric properties of the top liquid electrode; 2) simple test conditions whereby no labeling is required in the analyte solution to optically detect biomolecules; 3) effective sampling method through the design of an integrated microfluidic chip for hosting the top liquid electrode, ensuring good reproducibility and preventing contamination; 4) sensitive detection limit for heparin concentrations at clinically relevant levels, and 5) high compliance with industrial manufacturing standards. Agency for Science, Technology and Research (A*STAR) Ministry of Education (MOE) X.Q. thanks A*STAR SIMTech RPE funding (C18-A-037). K.P. thanks Singapore Ministry of Education, Academic Research Fund Tier 1 (2019-T1-002-045, RG125/19), Academic Research Fund Tier 2 (MOE2018-T2-2-042), and *STAR SERC AME Programmatic Fund (SERC A18A8b0059) for the financial support. 2022-10-11T04:51:16Z 2022-10-11T04:51:16Z 2022 Journal Article Qi, X., Wu, R., Lok, B. K., Kerk, W. T., Lai, S. F. K., Fan, W. & Pu, K. (2022). Biomolecule-interactive flexible light emitting capacitor display. Small, 18(4), e2103541-. https://dx.doi.org/10.1002/smll.202103541 1613-6810 https://hdl.handle.net/10356/162259 10.1002/smll.202103541 34841654 2-s2.0-85120084421 4 18 e2103541 en 2019-T1-002-045 RG125/19 MOE2018-T2-2-042 SERC A18A8b0059 Small © 2021 Wiley-VCH GmbH. All rights reserved. |
| spellingShingle | Engineering::Chemical engineering Biomolecules Liquid Electrodes Qi, Xiaoying Wu, Ruige Lok, Boon Keng Kerk, Wai Tat Lai, Steve Foo Khuen Fan, Wei Pu, Kanyi Biomolecule-interactive flexible light emitting capacitor display |
| title | Biomolecule-interactive flexible light emitting capacitor display |
| title_full | Biomolecule-interactive flexible light emitting capacitor display |
| title_fullStr | Biomolecule-interactive flexible light emitting capacitor display |
| title_full_unstemmed | Biomolecule-interactive flexible light emitting capacitor display |
| title_short | Biomolecule-interactive flexible light emitting capacitor display |
| title_sort | biomolecule interactive flexible light emitting capacitor display |
| topic | Engineering::Chemical engineering Biomolecules Liquid Electrodes |
| url | https://hdl.handle.net/10356/162259 |
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