Age-dependent effects of Igf2bp2 on gene regulation, function, and aging of hematopoietic stem cells in mice

Age-dependent effects of Igf2bp2 on gene regulation, function, and aging of hematopoietic stem cells in mice

Increasing evidence links metabolism, protein synthesis, and growth signaling to impairments in the function of hematopoietic stem and progenitor cells (HSPCs) during aging. The Lin28b/Hmga2 pathway controls tissue development, and the postnatal downregulation of this pathway limits the self-renewal...

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Bibliographic Details
Main Authors: Suo, Miaomiao, Rommelfanger, Megan K., Chen, Yulin, Amro, Elias Moris, Han, Bing, Chen, Zhiyang, Szafranski, Karol, Chakkarappan, Sundaram Reddy, Boehm, Bernhard Otto, MacLean, Adam L., Rudolph, K. Lenhard
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Journal Article
Language:English
Published: 2022
Subjects:
Science::Medicine
Aerobic Metabolism
RNA Binding Protein
Online Access:https://hdl.handle.net/10356/162482

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