Super enhancer-mediated upregulation of HJURP promotes growth and survival of t(4;14)-positive multiple myeloma

Super enhancer-mediated upregulation of HJURP promotes growth and survival of t(4;14)-positive multiple myeloma

Multiple myeloma is an incurable malignancy with marked clinical and genetic heterogeneity. The cytogenetic abnormality t(4;14) (p16.3;q32.3) confers aggressive behavior in multiple myeloma. Recently, essential oncogenic drivers in a wide range of cancers have been shown to be controlled by super-en...

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Detalhes bibliográficos
Main Authors: Jia, Yunlu, Zhou, Jianbiao, Tan, Tze King, Chung, Tae-Hoon, Chen, Yongxia, Chooi, Jing-Yuan, Sanda, Takaomi, Fullwood, Melissa Jane, Xiong, Sinan, Toh, Sabrina H. M., Balan, Kalpnaa, Wong, Regina W. J., Lim, Julia S. L., Zhang, Enfan, Cai, Zhen, Shen, Peng, Chng, Wee Joo
Outros Autores: School of Biological Sciences
Formato: Journal Article
Idioma:English
Publicado em: 2022
Assuntos:
Science::Biological sciences
Science::Medicine
Carcinogenesis
Apoptosis
Acesso em linha:https://hdl.handle.net/10356/162509

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