A series of five patients with oxyntic gland adenoma: deciphering the clinical and histological features of these rare gastric polyps

Oxyntic gland adenomas are rare lesions of the stomach, composed of oxyntic-type glands. A variety of nomenclatures have been used to designate it, including adenocarcinoma of fundic gland type and oxyntic mucosa pseudo-polyp. We report a series of five cases that demonstrate a spectrum of clinical...

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Bibliographic Details
Main Authors: Nagaputra, Jerry C., Loh, Tracy Jie Zhen, Mantoo, Sangeeta, Azhar, Rafay, Namasivayam, Vikneswaran, Leow, Wei Qiang
Other Authors: School of Biological Sciences
Format: Journal Article
Language:English
Published: 2022
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Online Access:https://hdl.handle.net/10356/162561
Description
Summary:Oxyntic gland adenomas are rare lesions of the stomach, composed of oxyntic-type glands. A variety of nomenclatures have been used to designate it, including adenocarcinoma of fundic gland type and oxyntic mucosa pseudo-polyp. We report a series of five cases that demonstrate a spectrum of clinical and morphological variations in oxyntic gland adenomas. Although all cases showed irregular, dilated oxyntic glands lined by predominantly chief cells with scattered parietal cells, one case showed at least moderate cytological atypia and another showed submucosal invasion. Despite these worrying features, all patients had no evidence of recurrence following successful endoscopic resections.