Probiotic supplementation for neonates with congenital gastrointestinal surgical conditions: guidelines for future research
Our pilot RCT found that probiotic supplementation with the three-strain bifidobacterial product (B. breve M-16V, B. longum subsp. infantis M-63 and B. longum subsp. longum BB536) attenuates gut dysbiosis, increases stool short-chain fatty acid (SCFA) levels and improves the growth of head circumfer...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
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2022
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| Online Access: | https://hdl.handle.net/10356/162584 |
| _version_ | 1826118821846450176 |
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| author | Rao, Shripada Esvaran, Meera Chen, Liwei Kok, Chooi Keil, Anthony D. Gollow, Ian Simmer, Karen Wemheuer, Bernd Conway, Patricia Patole, Sanjay |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Rao, Shripada Esvaran, Meera Chen, Liwei Kok, Chooi Keil, Anthony D. Gollow, Ian Simmer, Karen Wemheuer, Bernd Conway, Patricia Patole, Sanjay |
| author_sort | Rao, Shripada |
| collection | NTU |
| description | Our pilot RCT found that probiotic supplementation with the three-strain bifidobacterial product (B. breve M-16V, B. longum subsp. infantis M-63 and B. longum subsp. longum BB536) attenuates gut dysbiosis, increases stool short-chain fatty acid (SCFA) levels and improves the growth of head circumference in neonates with congenital gastrointestinal surgical conditions (CGISC). In this article, we have provided guidelines for designing future multicentre RCTs based on the experience gained from our pilot RCT. The recommendations include advice about sample size, potential confounders, outcomes of interest, probiotic strain selection, storage, dose, duration and microbial quality assurance, collection of stool samples, storage and analysis and reporting. Following these guidelines will increase the validity of future RCTs in this area and hence confidence in their results. IMPACT: Probiotic supplementation attenuates gut dysbiosis, increases stool short-chain fatty acid (SCFA) levels and improves the growth of head circumference in neonates with congenital gastrointestinal surgical conditions. The current review provides evidence-based guidelines to conduct adequately powered RCTs in this field. |
| first_indexed | 2024-10-01T04:50:08Z |
| format | Journal Article |
| id | ntu-10356/162584 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:50:08Z |
| publishDate | 2022 |
| record_format | dspace |
| spelling | ntu-10356/1625842023-12-29T06:48:18Z Probiotic supplementation for neonates with congenital gastrointestinal surgical conditions: guidelines for future research Rao, Shripada Esvaran, Meera Chen, Liwei Kok, Chooi Keil, Anthony D. Gollow, Ian Simmer, Karen Wemheuer, Bernd Conway, Patricia Patole, Sanjay School of Chemical and Biomedical Engineering Engineering::Bioengineering Neonates Gastrointestinal Conditions Our pilot RCT found that probiotic supplementation with the three-strain bifidobacterial product (B. breve M-16V, B. longum subsp. infantis M-63 and B. longum subsp. longum BB536) attenuates gut dysbiosis, increases stool short-chain fatty acid (SCFA) levels and improves the growth of head circumference in neonates with congenital gastrointestinal surgical conditions (CGISC). In this article, we have provided guidelines for designing future multicentre RCTs based on the experience gained from our pilot RCT. The recommendations include advice about sample size, potential confounders, outcomes of interest, probiotic strain selection, storage, dose, duration and microbial quality assurance, collection of stool samples, storage and analysis and reporting. Following these guidelines will increase the validity of future RCTs in this area and hence confidence in their results. IMPACT: Probiotic supplementation attenuates gut dysbiosis, increases stool short-chain fatty acid (SCFA) levels and improves the growth of head circumference in neonates with congenital gastrointestinal surgical conditions. The current review provides evidence-based guidelines to conduct adequately powered RCTs in this field. Published version This work was supported by the Centre for Neonatal Research and Education, Neonatal Directorate, Child and Adolescent Health Service, Western Australia. Open Access funding enabled and organized by CAUL and its Member Institutions. 2022-10-31T06:11:17Z 2022-10-31T06:11:17Z 2022 Journal Article Rao, S., Esvaran, M., Chen, L., Kok, C., Keil, A. D., Gollow, I., Simmer, K., Wemheuer, B., Conway, P. & Patole, S. (2022). Probiotic supplementation for neonates with congenital gastrointestinal surgical conditions: guidelines for future research. Pediatric Research, 1-7. https://dx.doi.org/10.1038/s41390-022-02087-8 0031-3998 https://hdl.handle.net/10356/162584 10.1038/s41390-022-02087-8 35505080 2-s2.0-85129326642 1 7 en Pediatric Research © Crown 2022. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. application/pdf |
| spellingShingle | Engineering::Bioengineering Neonates Gastrointestinal Conditions Rao, Shripada Esvaran, Meera Chen, Liwei Kok, Chooi Keil, Anthony D. Gollow, Ian Simmer, Karen Wemheuer, Bernd Conway, Patricia Patole, Sanjay Probiotic supplementation for neonates with congenital gastrointestinal surgical conditions: guidelines for future research |
| title | Probiotic supplementation for neonates with congenital gastrointestinal surgical conditions: guidelines for future research |
| title_full | Probiotic supplementation for neonates with congenital gastrointestinal surgical conditions: guidelines for future research |
| title_fullStr | Probiotic supplementation for neonates with congenital gastrointestinal surgical conditions: guidelines for future research |
| title_full_unstemmed | Probiotic supplementation for neonates with congenital gastrointestinal surgical conditions: guidelines for future research |
| title_short | Probiotic supplementation for neonates with congenital gastrointestinal surgical conditions: guidelines for future research |
| title_sort | probiotic supplementation for neonates with congenital gastrointestinal surgical conditions guidelines for future research |
| topic | Engineering::Bioengineering Neonates Gastrointestinal Conditions |
| url | https://hdl.handle.net/10356/162584 |
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