Intravital Ca²⁺ imaging of pancreatic β cell function after bariatric surgery
Bariatric surgery has long become an appropriate and common treatment for patients with severe obesity and many related conditions such as type 2 diabetes. However, the exact mechanism leading to improved metabolism shortly after surgery, most notably independent of weight loss, has not yet been ful...
| Main Authors: | , |
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| Format: | Journal Article |
| Language: | English |
| Published: |
2022
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| Online Access: | https://hdl.handle.net/10356/162618 |
| _version_ | 1811684148575731712 |
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| author | Tröster, Philip Berggren, Per-Olof |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Tröster, Philip Berggren, Per-Olof |
| author_sort | Tröster, Philip |
| collection | NTU |
| description | Bariatric surgery has long become an appropriate and common treatment for patients with severe obesity and many related conditions such as type 2 diabetes. However, the exact mechanism leading to improved metabolism shortly after surgery, most notably independent of weight loss, has not yet been fully elucidated. Akalestou's recent publication, "Intravital imaging of islet Ca2+ dynamics reveals enhanced β cell connectivity after bariatric surgery in mice," provides the first detailed insight into the progression of pancreatic islet function after bariatric surgery. By transplanting pancreatic islets equipped with a genetically encoded calcium indicator into the anterior chamber of the eye, improvements in Ca2+ dynamics and a more potent β cell network were observed over an extended time course after the surgical procedure. In the following sections, we will take the opportunity to briefly outline the association between bariatric surgery and diabetes, highlight the issue of anesthesia during intravital Ca2+ imaging, and finally comment on some biological relationships related to β cell function. |
| first_indexed | 2024-10-01T04:24:01Z |
| format | Journal Article |
| id | ntu-10356/162618 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:24:01Z |
| publishDate | 2022 |
| record_format | dspace |
| spelling | ntu-10356/1626182023-03-05T16:51:10Z Intravital Ca²⁺ imaging of pancreatic β cell function after bariatric surgery Tröster, Philip Berggren, Per-Olof Lee Kong Chian School of Medicine (LKCMedicine) Science::Medicine Bariatric Surgery Diabetes Mellitus Bariatric surgery has long become an appropriate and common treatment for patients with severe obesity and many related conditions such as type 2 diabetes. However, the exact mechanism leading to improved metabolism shortly after surgery, most notably independent of weight loss, has not yet been fully elucidated. Akalestou's recent publication, "Intravital imaging of islet Ca2+ dynamics reveals enhanced β cell connectivity after bariatric surgery in mice," provides the first detailed insight into the progression of pancreatic islet function after bariatric surgery. By transplanting pancreatic islets equipped with a genetically encoded calcium indicator into the anterior chamber of the eye, improvements in Ca2+ dynamics and a more potent β cell network were observed over an extended time course after the surgical procedure. In the following sections, we will take the opportunity to briefly outline the association between bariatric surgery and diabetes, highlight the issue of anesthesia during intravital Ca2+ imaging, and finally comment on some biological relationships related to β cell function. Published version Familjen Erling-Perssons Stiftelse, Stichting af Jochnick Foundation, Diabetesfonden, European Research Council (ERC) “Advanced Grant” (EYELETS), SSF Stiftelsen f ̈or Strategisk Forskning (Rambidrag MED-X 2018), KI Fonder, Vetenskapsrådet (The Swedisch Research Council), Berth von Kantzows Stiftelse, Novo Nordisk Foundation. 2022-11-01T04:40:58Z 2022-11-01T04:40:58Z 2022 Journal Article Tröster, P. & Berggren, P. (2022). Intravital Ca²⁺ imaging of pancreatic β cell function after bariatric surgery. Cell Calcium, 104, 102566-. https://dx.doi.org/10.1016/j.ceca.2022.102566 0143-4160 https://hdl.handle.net/10356/162618 10.1016/j.ceca.2022.102566 35278937 2-s2.0-85125935521 104 102566 en Cell Calcium © 2022 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). application/pdf |
| spellingShingle | Science::Medicine Bariatric Surgery Diabetes Mellitus Tröster, Philip Berggren, Per-Olof Intravital Ca²⁺ imaging of pancreatic β cell function after bariatric surgery |
| title | Intravital Ca²⁺ imaging of pancreatic β cell function after bariatric surgery |
| title_full | Intravital Ca²⁺ imaging of pancreatic β cell function after bariatric surgery |
| title_fullStr | Intravital Ca²⁺ imaging of pancreatic β cell function after bariatric surgery |
| title_full_unstemmed | Intravital Ca²⁺ imaging of pancreatic β cell function after bariatric surgery |
| title_short | Intravital Ca²⁺ imaging of pancreatic β cell function after bariatric surgery |
| title_sort | intravital ca²⁺ imaging of pancreatic β cell function after bariatric surgery |
| topic | Science::Medicine Bariatric Surgery Diabetes Mellitus |
| url | https://hdl.handle.net/10356/162618 |
| work_keys_str_mv | AT trosterphilip intravitalca2imagingofpancreaticbcellfunctionafterbariatricsurgery AT berggrenperolof intravitalca2imagingofpancreaticbcellfunctionafterbariatricsurgery |