Noninvasive follicular thyroid neoplasm with papillary-like nuclear features and the risk of malignancy in thyroid cytology: data from Singapore
INTRODUCTION: The impact of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) on the risk of malignancy (ROM) in fine-needle aspiration cytology (FNAC) per The Bethesda System for Reporting Thyroid Cytopathology has not been well reported in Singapore. METHODS: We...
| Main Authors: | , , , , , , , , , , , |
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| 其他作者: | |
| 格式: | Journal Article |
| 语言: | English |
| 出版: |
2022
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| 主题: | |
| 在线阅读: | https://hdl.handle.net/10356/162662 |
| _version_ | 1826118978918940672 |
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| author | Lee, Bryan Wei Wen Bundele, Manish Mahadeorao Tan, Rong Fu, Ernest Wei Zhong Chew, Agnes Siqi Wong, Junice Shi Hui Siew, Caroline Ching Hsia Lim, Brenda Su Ping Dalan, Rinkoo Lim, Ming Yann Gan, Jereme Yijin Li, Hao |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Lee, Bryan Wei Wen Bundele, Manish Mahadeorao Tan, Rong Fu, Ernest Wei Zhong Chew, Agnes Siqi Wong, Junice Shi Hui Siew, Caroline Ching Hsia Lim, Brenda Su Ping Dalan, Rinkoo Lim, Ming Yann Gan, Jereme Yijin Li, Hao |
| author_sort | Lee, Bryan Wei Wen |
| collection | NTU |
| description | INTRODUCTION: The impact of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) on the risk of malignancy (ROM) in fine-needle aspiration cytology (FNAC) per The Bethesda System for Reporting Thyroid Cytopathology has not been well reported in Singapore. METHODS: We retrospectively identified 821 thyroid nodules with preoperative FNAC from 788 patients out of 1,279 consecutive thyroidectomies performed between January 2010 and August 2016 in a tertiary general hospital in Singapore. Possible cases of NIFTP were reviewed for reclassification and the impact of NIFTP on ROM was analysed. RESULTS: The incidence of NIFTP was 1.2% (10 out of 821). If NIFTP is considered benign, ROM in Bethesda I through VI were 8.6%, 3.5%, 26.3%, 20.0%, 87.7%, 97.0% versus 8.6%, 4.2%, 28.1%, 26.7%, 89.2% and 100% if NIFTP is considered malignant. Eight patients with NIFTP had follow-up of 15 to 110 months. One had possible rib metastasis as evidenced by I131 uptake but remained free of structural or biochemical disease during a follow-up period of 110 months. None had lymph node metastasis at presentation, nor locoregional or distant recurrence. CONCLUSION: Classifying NIFTP as benign decreased ROM in Bethesda II through VI, but the benignity of NIFTP requires more prospective studies to ascertain. The impact of NIFTP on ROM in our institution also appears to be lower than that reported in the Western studies. |
| first_indexed | 2024-10-01T04:52:26Z |
| format | Journal Article |
| id | ntu-10356/162662 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:52:26Z |
| publishDate | 2022 |
| record_format | dspace |
| spelling | ntu-10356/1626622022-11-02T05:47:34Z Noninvasive follicular thyroid neoplasm with papillary-like nuclear features and the risk of malignancy in thyroid cytology: data from Singapore Lee, Bryan Wei Wen Bundele, Manish Mahadeorao Tan, Rong Fu, Ernest Wei Zhong Chew, Agnes Siqi Wong, Junice Shi Hui Siew, Caroline Ching Hsia Lim, Brenda Su Ping Dalan, Rinkoo Lim, Ming Yann Gan, Jereme Yijin Li, Hao Lee Kong Chian School of Medicine (LKCMedicine) Ministry of Health Holdings, Singapore Science::Medicine Bethesda Cytology INTRODUCTION: The impact of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) on the risk of malignancy (ROM) in fine-needle aspiration cytology (FNAC) per The Bethesda System for Reporting Thyroid Cytopathology has not been well reported in Singapore. METHODS: We retrospectively identified 821 thyroid nodules with preoperative FNAC from 788 patients out of 1,279 consecutive thyroidectomies performed between January 2010 and August 2016 in a tertiary general hospital in Singapore. Possible cases of NIFTP were reviewed for reclassification and the impact of NIFTP on ROM was analysed. RESULTS: The incidence of NIFTP was 1.2% (10 out of 821). If NIFTP is considered benign, ROM in Bethesda I through VI were 8.6%, 3.5%, 26.3%, 20.0%, 87.7%, 97.0% versus 8.6%, 4.2%, 28.1%, 26.7%, 89.2% and 100% if NIFTP is considered malignant. Eight patients with NIFTP had follow-up of 15 to 110 months. One had possible rib metastasis as evidenced by I131 uptake but remained free of structural or biochemical disease during a follow-up period of 110 months. None had lymph node metastasis at presentation, nor locoregional or distant recurrence. CONCLUSION: Classifying NIFTP as benign decreased ROM in Bethesda II through VI, but the benignity of NIFTP requires more prospective studies to ascertain. The impact of NIFTP on ROM in our institution also appears to be lower than that reported in the Western studies. 2022-11-02T05:47:34Z 2022-11-02T05:47:34Z 2021 Journal Article Lee, B. W. W., Bundele, M. M., Tan, R., Fu, E. W. Z., Chew, A. S., Wong, J. S. H., Siew, C. C. H., Lim, B. S. P., Dalan, R., Lim, M. Y., Gan, J. Y. & Li, H. (2021). Noninvasive follicular thyroid neoplasm with papillary-like nuclear features and the risk of malignancy in thyroid cytology: data from Singapore. Annals of the Academy of Medicine, Singapore, 50(12), 903-910. https://dx.doi.org/10.47102/annals-acadmedsg.2021243 0304-4602 https://hdl.handle.net/10356/162662 10.47102/annals-acadmedsg.2021243 50 2-s2.0-85123231911 12 50 903 910 en Annals of the Academy of Medicine, Singapore © 2021 Academy of Medicine of Singapore. All rights reserved. |
| spellingShingle | Science::Medicine Bethesda Cytology Lee, Bryan Wei Wen Bundele, Manish Mahadeorao Tan, Rong Fu, Ernest Wei Zhong Chew, Agnes Siqi Wong, Junice Shi Hui Siew, Caroline Ching Hsia Lim, Brenda Su Ping Dalan, Rinkoo Lim, Ming Yann Gan, Jereme Yijin Li, Hao Noninvasive follicular thyroid neoplasm with papillary-like nuclear features and the risk of malignancy in thyroid cytology: data from Singapore |
| title | Noninvasive follicular thyroid neoplasm with papillary-like nuclear features and the risk of malignancy in thyroid cytology: data from Singapore |
| title_full | Noninvasive follicular thyroid neoplasm with papillary-like nuclear features and the risk of malignancy in thyroid cytology: data from Singapore |
| title_fullStr | Noninvasive follicular thyroid neoplasm with papillary-like nuclear features and the risk of malignancy in thyroid cytology: data from Singapore |
| title_full_unstemmed | Noninvasive follicular thyroid neoplasm with papillary-like nuclear features and the risk of malignancy in thyroid cytology: data from Singapore |
| title_short | Noninvasive follicular thyroid neoplasm with papillary-like nuclear features and the risk of malignancy in thyroid cytology: data from Singapore |
| title_sort | noninvasive follicular thyroid neoplasm with papillary like nuclear features and the risk of malignancy in thyroid cytology data from singapore |
| topic | Science::Medicine Bethesda Cytology |
| url | https://hdl.handle.net/10356/162662 |
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