Looking deep inside tissue with photoacoustic molecular probes: a review
Significance: Deep tissue noninvasive high-resolution imaging with light is challenging due to the high degree of light absorption and scattering in biological tissue. Photoacoustic imaging (PAI) can overcome some of the challenges of pure optical or ultrasound imaging to provide high-resolution dee...
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| Materialtyp: | Journal Article |
| Språk: | English |
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2022
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| Länkar: | https://hdl.handle.net/10356/162731 |
| _version_ | 1826129368326340608 |
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| author | Xie, Hui Mohammad O. A. Malik Pramanik, Manojit |
| author2 | School of Chemistry, Chemical Engineering and Biotechnology |
| author_facet | School of Chemistry, Chemical Engineering and Biotechnology Xie, Hui Mohammad O. A. Malik Pramanik, Manojit |
| author_sort | Xie, Hui |
| collection | NTU |
| description | Significance: Deep tissue noninvasive high-resolution imaging with light is challenging due to the high degree of light absorption and scattering in biological tissue. Photoacoustic imaging (PAI) can overcome some of the challenges of pure optical or ultrasound imaging to provide high-resolution deep tissue imaging. However, label-free PAI signals from light absorbing chromophores within the tissue are nonspecific. The use of exogeneous contrast agents (probes) not only enhances the imaging contrast (and imaging depth) but also increases the specificity of PAI by binding only to targeted molecules and often providing signals distinct from the background. Aim: We aim to review the current development and future progression of photoacoustic molecular probes/contrast agents. Approach: First, PAI and the need for using contrast agents are briefly introduced. Then, the recent development of contrast agents in terms of materials used to construct them is discussed. Then, various probes are discussed based on targeting mechanisms, in vivo molecular imaging applications, multimodal uses, and use in theranostic applications. Results: Material combinations are being used to develop highly specific contrast agents. In addition to passive accumulation, probes utilizing activation mechanisms show promise for greater controllability. Several probes also enable concurrent multimodal use with fluorescence, ultrasound, Raman, magnetic resonance imaging, and computed tomography. Finally, targeted probes are also shown to aid localized and molecularly specific photo-induced therapy. Conclusions: The development of contrast agents provides a promising prospect for increased contrast, higher imaging depth, and molecularly specific information. Of note are agents that allow for controlled activation, explore other optical windows, and enable multimodal use to overcome some of the shortcomings of label-free PAI. |
| first_indexed | 2024-10-01T07:39:26Z |
| format | Journal Article |
| id | ntu-10356/162731 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:39:26Z |
| publishDate | 2022 |
| record_format | dspace |
| spelling | ntu-10356/1627312023-06-21T08:01:17Z Looking deep inside tissue with photoacoustic molecular probes: a review Xie, Hui Mohammad O. A. Malik Pramanik, Manojit School of Chemistry, Chemical Engineering and Biotechnology Engineering::Bioengineering Photoacoustic Imaging Molecular Imaging Significance: Deep tissue noninvasive high-resolution imaging with light is challenging due to the high degree of light absorption and scattering in biological tissue. Photoacoustic imaging (PAI) can overcome some of the challenges of pure optical or ultrasound imaging to provide high-resolution deep tissue imaging. However, label-free PAI signals from light absorbing chromophores within the tissue are nonspecific. The use of exogeneous contrast agents (probes) not only enhances the imaging contrast (and imaging depth) but also increases the specificity of PAI by binding only to targeted molecules and often providing signals distinct from the background. Aim: We aim to review the current development and future progression of photoacoustic molecular probes/contrast agents. Approach: First, PAI and the need for using contrast agents are briefly introduced. Then, the recent development of contrast agents in terms of materials used to construct them is discussed. Then, various probes are discussed based on targeting mechanisms, in vivo molecular imaging applications, multimodal uses, and use in theranostic applications. Results: Material combinations are being used to develop highly specific contrast agents. In addition to passive accumulation, probes utilizing activation mechanisms show promise for greater controllability. Several probes also enable concurrent multimodal use with fluorescence, ultrasound, Raman, magnetic resonance imaging, and computed tomography. Finally, targeted probes are also shown to aid localized and molecularly specific photo-induced therapy. Conclusions: The development of contrast agents provides a promising prospect for increased contrast, higher imaging depth, and molecularly specific information. Of note are agents that allow for controlled activation, explore other optical windows, and enable multimodal use to overcome some of the shortcomings of label-free PAI. Ministry of Education (MOE) Published version The author would like to acknowledge the support by the Tier 1 Grant funded by the Ministry of Education in Singapore (RG30/21, RG127/19, RT16/19). 2022-11-09T02:00:17Z 2022-11-09T02:00:17Z 2022 Journal Article Xie, H., Mohammad O. A. Malik & Pramanik, M. (2022). Looking deep inside tissue with photoacoustic molecular probes: a review. Journal of Biomedical Optics, 27(7), 070901-. https://dx.doi.org/10.1117/1.JBO.27.7.070901 1083-3668 https://hdl.handle.net/10356/162731 10.1117/1.JBO.27.7.070901 2-s2.0-85135411500 7 27 070901 en RG30/21 RG127/19 RT16/19 Journal of Biomedical Optics © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 International License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI. [DOI: 10.1117/1.JBO.27.7.070901] application/pdf |
| spellingShingle | Engineering::Bioengineering Photoacoustic Imaging Molecular Imaging Xie, Hui Mohammad O. A. Malik Pramanik, Manojit Looking deep inside tissue with photoacoustic molecular probes: a review |
| title | Looking deep inside tissue with photoacoustic molecular probes: a review |
| title_full | Looking deep inside tissue with photoacoustic molecular probes: a review |
| title_fullStr | Looking deep inside tissue with photoacoustic molecular probes: a review |
| title_full_unstemmed | Looking deep inside tissue with photoacoustic molecular probes: a review |
| title_short | Looking deep inside tissue with photoacoustic molecular probes: a review |
| title_sort | looking deep inside tissue with photoacoustic molecular probes a review |
| topic | Engineering::Bioengineering Photoacoustic Imaging Molecular Imaging |
| url | https://hdl.handle.net/10356/162731 |
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