A silk-microneedle patch to detect glucose in the interstitial fluid of skin or plant tissue
Glucose is critical to all organisms. Herein, we developed a wire electrode embedded microneedle patch (WEMNP) for in situ real-time detection of glucose in the interstitial fluid (ISF) of skin or plant tissues with minimal invasiveness. WEMNP is made of proline treated silk fibroin proteins, which...
| Main Authors: | , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2022
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| Online Access: | https://hdl.handle.net/10356/162771 |
| _version_ | 1826125834660872192 |
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| author | Zheng, Lewen Zhu, Dan Dan Wang, Wenjun Liu, Jiyang Thng, Steven Tien Guan Chen, Peng |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Zheng, Lewen Zhu, Dan Dan Wang, Wenjun Liu, Jiyang Thng, Steven Tien Guan Chen, Peng |
| author_sort | Zheng, Lewen |
| collection | NTU |
| description | Glucose is critical to all organisms. Herein, we developed a wire electrode embedded microneedle patch (WEMNP) for in situ real-time detection of glucose in the interstitial fluid (ISF) of skin or plant tissues with minimal invasiveness. WEMNP is made of proline treated silk fibroin proteins, which provide good mechanical strength (0.75 N/microneedle) for tissue penetration and desirable bioelectronic interface for fast and high-fidelity detection. WEMNP shows specific and linear response to glucose between 3 and 18 mM for detection in skin ISF with a sensitivity of 21.21 nA/mM and between 30 and 180 mM for detection in plant ISF with a sensitivity of 1.22 nA/mM. Such self-administrable WEMNP could be instrumental to long-term home-based management for chronic diseases and to smart agriculturing. |
| first_indexed | 2024-10-01T06:43:10Z |
| format | Journal Article |
| id | ntu-10356/162771 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:43:10Z |
| publishDate | 2022 |
| record_format | dspace |
| spelling | ntu-10356/1627712023-11-01T06:56:42Z A silk-microneedle patch to detect glucose in the interstitial fluid of skin or plant tissue Zheng, Lewen Zhu, Dan Dan Wang, Wenjun Liu, Jiyang Thng, Steven Tien Guan Chen, Peng Lee Kong Chian School of Medicine (LKCMedicine) School of Chemistry, Chemical Engineering and Biotechnology Engineering::Chemical engineering Microneedles Glucose Detection Glucose is critical to all organisms. Herein, we developed a wire electrode embedded microneedle patch (WEMNP) for in situ real-time detection of glucose in the interstitial fluid (ISF) of skin or plant tissues with minimal invasiveness. WEMNP is made of proline treated silk fibroin proteins, which provide good mechanical strength (0.75 N/microneedle) for tissue penetration and desirable bioelectronic interface for fast and high-fidelity detection. WEMNP shows specific and linear response to glucose between 3 and 18 mM for detection in skin ISF with a sensitivity of 21.21 nA/mM and between 30 and 180 mM for detection in plant ISF with a sensitivity of 1.22 nA/mM. Such self-administrable WEMNP could be instrumental to long-term home-based management for chronic diseases and to smart agriculturing. Ministry of Education (MOE) Submitted/Accepted version This research was financially supported by AcRF Tier-1 Grants (RG110/20 and RT02/20) and AcRF Tier-2 grant (MOE2019-T2-2-004) from Singapore Ministry of Education. 2022-11-08T08:00:24Z 2022-11-08T08:00:24Z 2022 Journal Article Zheng, L., Zhu, D. D., Wang, W., Liu, J., Thng, S. T. G. & Chen, P. (2022). A silk-microneedle patch to detect glucose in the interstitial fluid of skin or plant tissue. Sensors and Actuators B: Chemical, 372, 132626-. https://dx.doi.org/10.1016/j.snb.2022.132626 0925-4005 https://hdl.handle.net/10356/162771 10.1016/j.snb.2022.132626 2-s2.0-85138048111 372 132626 en RG110/20 RT02/20 MOE2019-T2-2-004 Sensors and Actuators B: Chemical 10.21979/N9/WYLCBJ © 2022 Elsevier B.V. All rights reserved. This paper was published in Sensors and Actuators B: Chemical and is made available with permission of Elsevier B.V. application/pdf |
| spellingShingle | Engineering::Chemical engineering Microneedles Glucose Detection Zheng, Lewen Zhu, Dan Dan Wang, Wenjun Liu, Jiyang Thng, Steven Tien Guan Chen, Peng A silk-microneedle patch to detect glucose in the interstitial fluid of skin or plant tissue |
| title | A silk-microneedle patch to detect glucose in the interstitial fluid of skin or plant tissue |
| title_full | A silk-microneedle patch to detect glucose in the interstitial fluid of skin or plant tissue |
| title_fullStr | A silk-microneedle patch to detect glucose in the interstitial fluid of skin or plant tissue |
| title_full_unstemmed | A silk-microneedle patch to detect glucose in the interstitial fluid of skin or plant tissue |
| title_short | A silk-microneedle patch to detect glucose in the interstitial fluid of skin or plant tissue |
| title_sort | silk microneedle patch to detect glucose in the interstitial fluid of skin or plant tissue |
| topic | Engineering::Chemical engineering Microneedles Glucose Detection |
| url | https://hdl.handle.net/10356/162771 |
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