Hemicyanine-based near-infrared activatable probes for imaging and diagnosis of diseases
Molecular activatable probes with near-infrared (NIR) fluorescence play a critical role in in vivo imaging of biomarkers for drug screening and disease diagnosis. With structural diversity and high fluorescence quantum yields, hemicyanine dyes have emerged as a versatile scaffold for the constructio...
| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2022
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/162817 |
| _version_ | 1811686672268525568 |
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| author | Zeng, Ziling Liew, Si Si Wei, Xin Pu, Kanyi |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Zeng, Ziling Liew, Si Si Wei, Xin Pu, Kanyi |
| author_sort | Zeng, Ziling |
| collection | NTU |
| description | Molecular activatable probes with near-infrared (NIR) fluorescence play a critical role in in vivo imaging of biomarkers for drug screening and disease diagnosis. With structural diversity and high fluorescence quantum yields, hemicyanine dyes have emerged as a versatile scaffold for the construction of activatable optical probes. This Review presents a survey of hemicyanine-based NIR activatable probes (HNAPs) for in vivo imaging and early diagnosis of diseases. The molecular design principles of HNAPs towards activatable optical signaling against various biomarkers are discussed with a focus on their broad applications in the detection of diseases including inflammation, acute organ failure, skin diseases, intestinal diseases, and cancer. This progress not only proves the unique value of HNAPs in preclinical research but also highlights their high translational potential in clinical diagnosis. |
| first_indexed | 2024-10-01T05:04:08Z |
| format | Journal Article |
| id | ntu-10356/162817 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T05:04:08Z |
| publishDate | 2022 |
| record_format | dspace |
| spelling | ntu-10356/1628172022-11-10T04:44:22Z Hemicyanine-based near-infrared activatable probes for imaging and diagnosis of diseases Zeng, Ziling Liew, Si Si Wei, Xin Pu, Kanyi School of Chemical and Biomedical Engineering School of Physical and Mathematical Sciences Engineering::Bioengineering Science::Chemistry Activatable Probes Optical Imaging Molecular activatable probes with near-infrared (NIR) fluorescence play a critical role in in vivo imaging of biomarkers for drug screening and disease diagnosis. With structural diversity and high fluorescence quantum yields, hemicyanine dyes have emerged as a versatile scaffold for the construction of activatable optical probes. This Review presents a survey of hemicyanine-based NIR activatable probes (HNAPs) for in vivo imaging and early diagnosis of diseases. The molecular design principles of HNAPs towards activatable optical signaling against various biomarkers are discussed with a focus on their broad applications in the detection of diseases including inflammation, acute organ failure, skin diseases, intestinal diseases, and cancer. This progress not only proves the unique value of HNAPs in preclinical research but also highlights their high translational potential in clinical diagnosis. Ministry of Education (MOE) K.P. thanks Singapore Ministry of Education, Academic Research Fund Tier 1 (2019-T1-002-045, RG125/19, RT05/20), Academic Research Fund Tier 2 (MOE2018-T2-2-042), and A*STAR SERC AME Programmatic Fund (SERCA18A8b0059) for the financial support. 2022-11-10T04:37:30Z 2022-11-10T04:37:30Z 2021 Journal Article Zeng, Z., Liew, S. S., Wei, X. & Pu, K. (2021). Hemicyanine-based near-infrared activatable probes for imaging and diagnosis of diseases. Angewandte Chemie International Edition, 60(51), 26454-26475. https://dx.doi.org/10.1002/anie.202107877 1433-7851 https://hdl.handle.net/10356/162817 10.1002/anie.202107877 34263981 2-s2.0-85112033728 51 60 26454 26475 en 2019-T1-002-045 RG125/19 RT05/20 MOE2018-T2-2-042 A18A8b0059 Angewandte Chemie International Edition © 2021 Wiley-VCH GmbH. All rights reserved. |
| spellingShingle | Engineering::Bioengineering Science::Chemistry Activatable Probes Optical Imaging Zeng, Ziling Liew, Si Si Wei, Xin Pu, Kanyi Hemicyanine-based near-infrared activatable probes for imaging and diagnosis of diseases |
| title | Hemicyanine-based near-infrared activatable probes for imaging and diagnosis of diseases |
| title_full | Hemicyanine-based near-infrared activatable probes for imaging and diagnosis of diseases |
| title_fullStr | Hemicyanine-based near-infrared activatable probes for imaging and diagnosis of diseases |
| title_full_unstemmed | Hemicyanine-based near-infrared activatable probes for imaging and diagnosis of diseases |
| title_short | Hemicyanine-based near-infrared activatable probes for imaging and diagnosis of diseases |
| title_sort | hemicyanine based near infrared activatable probes for imaging and diagnosis of diseases |
| topic | Engineering::Bioengineering Science::Chemistry Activatable Probes Optical Imaging |
| url | https://hdl.handle.net/10356/162817 |
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