Hybrid polymer networks of carbene and thiol ene
Thiol/ene-based resorbable elastomers display tough elongation but lack adhesion to soft tissues. Carbene-based bioadhesives (e.g. CaproGlu) allow soft tissue adhesion, but the covalent crosslinks limit extensibility after photoactivation. Herein thiol/ene resorbable elastomers are combined with a c...
| Main Authors: | , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
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2022
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| Online Access: | https://hdl.handle.net/10356/162855 |
| _version_ | 1826114051834380288 |
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| author | Djordjevic, Ivan Wicaksono, Gautama Singh, Juhi Singh, Manisha Ellis, Elizabeth G. Alraddadi, Maher A Dove, Andrew P. Steele, Terry W. J. |
| author2 | School of Materials Science and Engineering |
| author_facet | School of Materials Science and Engineering Djordjevic, Ivan Wicaksono, Gautama Singh, Juhi Singh, Manisha Ellis, Elizabeth G. Alraddadi, Maher A Dove, Andrew P. Steele, Terry W. J. |
| author_sort | Djordjevic, Ivan |
| collection | NTU |
| description | Thiol/ene-based resorbable elastomers display tough elongation but lack adhesion to soft tissues. Carbene-based bioadhesives (e.g. CaproGlu) allow soft tissue adhesion, but the covalent crosslinks limit extensibility after photoactivation. Herein thiol/ene resorbable elastomers are combined with a carbene bioadhesive into a 3-component hybrid network by exploiting tunable photoactivation of each macromolecule independently or simultaneously. Dual crosslinking was monitored by photorheometry, where 405 nm initiates formation of a thiol/ene elastomeric network, followed by 365 nm activation of diazirine-grafted polycaprolactone tetrol (CaproGlu). Dynamic shear moduli, gelation point, elongation at break, and lap shear stress of the hybrid polymer network are evaluated with respect to absorbed light energy dose. Surface-exposed unreacted CaproGlu enables adhesion of the hybrid network to various substrates, as well as intermolecular crosslinking within the transparent matrix. The network morphology and functional group conversion is evaluated through scanning electron microscopy and infrared spectroscopy, respectively. For the first time, we demonstrate hybrid thiol/ene/diazirine double sided bioadhesives with tunable dynamic moduli in the range of 10–800 kPa and 160 kPa lap-shear adhesion strength. |
| first_indexed | 2024-10-01T03:33:12Z |
| format | Journal Article |
| id | ntu-10356/162855 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T03:33:12Z |
| publishDate | 2022 |
| record_format | dspace |
| spelling | ntu-10356/1628552023-03-05T16:28:31Z Hybrid polymer networks of carbene and thiol ene Djordjevic, Ivan Wicaksono, Gautama Singh, Juhi Singh, Manisha Ellis, Elizabeth G. Alraddadi, Maher A Dove, Andrew P. Steele, Terry W. J. School of Materials Science and Engineering School of Chemical and Biomedical Engineering Interdisciplinary Graduate School (IGS) NTU Institute for Health Technologies Engineering::Materials::Biomaterials Science::Chemistry::Organic chemistry::Polymers Hybrid Polymer Network Diazirine-Grafted Polycaprolactone Light Curing Crosslinked Elastomer Double Sided Adhesive. Thiol/ene-based resorbable elastomers display tough elongation but lack adhesion to soft tissues. Carbene-based bioadhesives (e.g. CaproGlu) allow soft tissue adhesion, but the covalent crosslinks limit extensibility after photoactivation. Herein thiol/ene resorbable elastomers are combined with a carbene bioadhesive into a 3-component hybrid network by exploiting tunable photoactivation of each macromolecule independently or simultaneously. Dual crosslinking was monitored by photorheometry, where 405 nm initiates formation of a thiol/ene elastomeric network, followed by 365 nm activation of diazirine-grafted polycaprolactone tetrol (CaproGlu). Dynamic shear moduli, gelation point, elongation at break, and lap shear stress of the hybrid polymer network are evaluated with respect to absorbed light energy dose. Surface-exposed unreacted CaproGlu enables adhesion of the hybrid network to various substrates, as well as intermolecular crosslinking within the transparent matrix. The network morphology and functional group conversion is evaluated through scanning electron microscopy and infrared spectroscopy, respectively. For the first time, we demonstrate hybrid thiol/ene/diazirine double sided bioadhesives with tunable dynamic moduli in the range of 10–800 kPa and 160 kPa lap-shear adhesion strength. Agency for Science, Technology and Research (A*STAR) Ministry of Education (MOE) Nanyang Technological University Submitted/Accepted version This work is funded by Institute of Advanced Studies Birmingham Visiting Fellowship, ‘Strong Elastomeric Bioadhesives Towards Tendon Repair’; Ministry of Education Tier 1 Grant RT07/20: Fiber-optic orthopaedic implants for bone-implant adhesion, Ministry of Education Tier 2 Grant (MOE2018-T2-2-114): CaproGlu, Double sided wet-tissue adhesives, NTUitive POC (Gap) Fund NGF/2018/05: Aesthetic Applications of CaproGlu Bioadhesives, and A*STAR IAF PP Grant (H19/01/ a0/0II9): CathoGlu Bioadhesives-preventing catheter extravasation and skin infections. 2022-11-11T02:26:28Z 2022-11-11T02:26:28Z 2022 Journal Article Djordjevic, I., Wicaksono, G., Singh, J., Singh, M., Ellis, E. G., Alraddadi, M. A., Dove, A. P. & Steele, T. W. J. (2022). Hybrid polymer networks of carbene and thiol ene. European Polymer Journal, 178, 111502-. https://dx.doi.org/10.1016/j.eurpolymj.2022.111502 0014-3057 https://hdl.handle.net/10356/162855 10.1016/j.eurpolymj.2022.111502 2-s2.0-85136136031 178 111502 en RT07/20 MOE2018-T2-2-114 NGF/2018/05 H19/01/ a0/0II9 European Polymer Journal © 2022 Elsevier Ltd. All rights reserved. This paper was published in European Polymer Journal and is made available with permission of Elsevier Ltd. application/pdf application/pdf |
| spellingShingle | Engineering::Materials::Biomaterials Science::Chemistry::Organic chemistry::Polymers Hybrid Polymer Network Diazirine-Grafted Polycaprolactone Light Curing Crosslinked Elastomer Double Sided Adhesive. Djordjevic, Ivan Wicaksono, Gautama Singh, Juhi Singh, Manisha Ellis, Elizabeth G. Alraddadi, Maher A Dove, Andrew P. Steele, Terry W. J. Hybrid polymer networks of carbene and thiol ene |
| title | Hybrid polymer networks of carbene and thiol ene |
| title_full | Hybrid polymer networks of carbene and thiol ene |
| title_fullStr | Hybrid polymer networks of carbene and thiol ene |
| title_full_unstemmed | Hybrid polymer networks of carbene and thiol ene |
| title_short | Hybrid polymer networks of carbene and thiol ene |
| title_sort | hybrid polymer networks of carbene and thiol ene |
| topic | Engineering::Materials::Biomaterials Science::Chemistry::Organic chemistry::Polymers Hybrid Polymer Network Diazirine-Grafted Polycaprolactone Light Curing Crosslinked Elastomer Double Sided Adhesive. |
| url | https://hdl.handle.net/10356/162855 |
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