Lack of ZnT8 protects pancreatic islets from hypoxia- and cytokine-induced cell death

Lack of ZnT8 protects pancreatic islets from hypoxia- and cytokine-induced cell death

Pancreatic β-cells depend on the well-balanced regulation of cytosolic zinc concentrations, providing sufficient zinc ions for the processing and storage of insulin, but avoiding toxic effects. The zinc transporter ZnT8, encoded by SLC30A8,is a key player regarding islet cell zinc homeostasis, and p...

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Bibliographic Details
Main Authors: Karsai, Maria, Zuellig, Richard A., Lehmann, Roger, Cuozzo, Federica, Nasteska, Daniela, Luca, Edlira, Hantel, Constanze, Hodson, David J., Spinas, Giatgen A., Rutter, Guy A., Gerber, Philipp A.
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Journal Article
Language:English
Published: 2022
Subjects:
Science::Medicine
Beta Cell
Hypoxia
Online Access:https://hdl.handle.net/10356/162958

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